A5004874607- Public Administration and Political Analysis
- Animal Nutrition and Physiology
- E-Government and Public Services
- Information Technology Governance and Strategy
- Corporate Social Responsibility and Sustainability
- Corporate Governance and Management
- Ruminant Nutrition and Digestive Physiology
- Business Process Modeling and Analysis
- Law and Political Science
- Digitalization, Law, and Regulation
- Rabbits: Nutrition, Reproduction, Health
- Meat and Animal Product Quality
- Animal Behavior and Welfare Studies
- Insect Utilization and Effects
- Big Data and Business Intelligence
- Innovation, Technology, and Society
- Genetic Syndromes and Imprinting
- semigroups and automata theory
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- ERP Systems Implementation and Impact
- Technology Adoption and User Behaviour
- Trace Elements in Health
- Veterinary Equine Medical Research
- Orthopaedic implants and arthroplasty
University of Rostock
2016-2024
University of Zurich
2023
Zhejiang University
2023
Universität Trier
2022-2023
University of Bergen
2023
Ludwig-Maximilians-Universität München
1998-2022
The Open University
2022
Technical University of Munich
2006-2021
Helmholtz Zentrum München
2015-2021
University of Veterinary Medicine Hannover, Foundation
2006-2020
Disease risk and incidence between males females reveal differences, sex is an important component of any investigation the determinants phenotypes or disease etiology. Further striking differences men women are known, for instance, at metabolic level. The extent to which vary level epigenome, however, not well documented. DNA methylation best known epigenetic mechanism date.In order shed light on we compared autosomal levels in blood a large prospective European cohort 1799 subjects,...
Good clinical outcome after digital nerve repair is highly relevant for proper hand function and has a significant socioeconomic impact. However, level of evidence competing surgical techniques low. The aim to summarize compare the outcomes with different methods (end-to-end end-to-side coaptations, grafts, artificial conduit-, vein-, muscle, muscle-in-vein reconstructions, replantations) provide an aid choosing individual technique reconstruction create reference values standard...
Protein Tyrosin Kinase 7 (PTK7) is upregulated in several human cancers; however, its clinical implication breast cancer (BC) and lymph node (LN) still unclear. In order to investigate the function of PTK7 mediating BC cell motility invasivity, expression lines was determined. signaling highly invasive cells inhibited by a dominant-negative mutant, an antibody against extracellular domain PTK7, siRNA knockdown PTK7. This resulted decreased invasivity cells. We further examined LN tissue 128...
Purpose – Business process change (BPC) initiatives are complex endeavors, which require many different sets of capabilities from the organization (e.g. IT, management, project management capabilities). This study aims to examine matter for successful BPC. Design/methodology/approach The paper posits that a structured analysis case studies will help in identifying relevant Against this background, adopted survey methodology, combines richness with benefit analyzing large quantities data....
Abstract Pancreatic carcinoma is one of the most aggressive tumor entities, and standard chemotherapy provides only modest benefit. Therefore, specific targeting pancreatic cancer for early diagnosis therapeutic intervention great interest. We have previously shown that cellular receptor Shiga toxin B (STxB), glycosphingolipid globotriaosylceramide (Gb3 or CD77) strongly increased in colorectal adenocarcinoma their metastases. Here, we report an upregulation Gb3 (21 27 cases) as compared...
Purpose The aim of this study was to investigate prospectively whether MRI plaque imaging can identify patients with asymptomatic carotid artery stenosis who have an increased risk for future cerebral events. allows categorization into different lesion types (I–VIII). Within these types, IV–V and VI are regarded as rupture-prone plaques, whereas the other represent stable ones. Methods Eighty-three consecutive (45 male (54.2%); age 54–88 years (mean 73.2 years)) presenting 50–99% according...
Hypertension represents a major cardiovascular risk factor. The pathophysiology of increased blood pressure (BP) is not yet completely understood. Transcriptome profiling offers possibilities to uncover genetics effects on BP. Based 2 populations including 2549 individuals, meta-analyses monocytic transcriptome-wide profiles were performed identify transcripts associated with Replication was in independent studies whole-blood transcriptome data 1990 individuals. For identified candidate...
ABSTRACT Helicobacter pylori colonizes half of the world's population, and infection can lead to ulcers, gastric cancer, mucosa-associated lymphoid tissue (MALT) lymphoma. Serology is only test applicable for large-scale, population-based screening, but current tests are hampered by a lack sensitivity and/or specificity. Also, no serologic allows differentiation type I II strains, which important predicting clinical outcome. H. virulence factors have been associated with disease, direct...
OBJECTIVE To test the hypothesis that replacement of sucrose with isomaltulose in sweet foods and beverages improves metabolic control patients type 2 diabetes. RESEARCH DESIGN AND METHODS One hundred ten diabetes were randomized to receive containing either 50 g/day or for 12 weeks as part their habitual diet under free-living conditions. HbA1c at was primary outcome parameter. RESULTS In final analysis comprising 101 patients, did not significantly affect (sucrose: 7.39 ± 0.78%;...
Advising patients about when they can drive after surgery is common practice arthroplasty of the knee or hip. In literature, preoperative braking performance values are frequently taken as "safe" landmark. We hypothesised that osteoarthritis (OA), most frequent reason for arthroplasty, already compromises ability to perform an emergency stop. expected both Reaction Time (RT) and Movement (MT) components Total Brake Response (TBRT), would be prolonged in with OA hip comparison healthy...
Governments worldwide engage in open government initiatives for making their data and related information available to the public. But success of is contingent upon public's willingness use exploit these sets. need have a clear understanding factors impacting users' intentions make offerings. In this paper, we answer following research question: What influence intention services offerings? We empirically analyze an online survey, which was administered six countries 2013 with over 6.000...
A deeper engagement into medical decision-making is demanded by treatment guidelines for patients with affective disorders. There to date little evidence on what facilitates active behaviour of depression. In general medicine 'question prompt sheets' (QPSs) have been shown change patients' in the consultation and improve satisfaction but there no such interventions mental health settings.To study effects a QPS patient consultation.Randomized controlled trial (involving N = 100 outpatients...
E-government promises to transform the public sector by enhancing transparency, efficiency and accessibility of services. While most e-government endeavors continue lag far behind their expected potentials, some nations adopt faster than others. Despite having one advanced telecommunications infrastructures in world, adoption Germany has fallen below expectations. Prior literature suggests that national culture shapes perception citizens thus facilitates or impedes new technologies. We argue...
To investigate the olfactory/gustatory functions of patients with inflammatory bowel disease (IBD) by smell/taste tests, and to determine if activity or medication might influence patients.In total, 59 IBD (37 Crohn's (CD) 22 ulcerative colitis (UC) patients) were studied using "Sniffin' sticks" "taste strips" for olfactory gustatory respectively, compared healthy controls published normative data.Among (CD UC) patients, values odor threshold, but not identification discrimination,...