Paula Singmann
A5072594294- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Biochemical effects in animals
- Computational Drug Discovery Methods
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Fatty Acid Research and Health
- Diabetes Treatment and Management
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Endoplasmic Reticulum Stress and Disease
- Birth, Development, and Health
- Pediatric health and respiratory diseases
- Nutrition, Genetics, and Disease
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
Helmholtz Zentrum München
2009-2021
Center for Environmental Health
2009-2012
Summary Understanding the complexity of aging is utmost importance. This can now be addressed by novel and powerful approach metabolomics. However, to date, only a few metabolic studies based on large samples are available. Here, we provide specific information age‐related metabolite concentration changes in human homeostasis. We report results from two population‐based studies: KORA F4 study Germany as discovery cohort, with 1038 female 1124 male participants (32–81 years), TwinsUK...
Disease risk and incidence between males females reveal differences, sex is an important component of any investigation the determinants phenotypes or disease etiology. Further striking differences men women are known, for instance, at metabolic level. The extent to which vary level epigenome, however, not well documented. DNA methylation best known epigenetic mechanism date.In order shed light on we compared autosomal levels in blood a large prospective European cohort 1799 subjects,...
<b><i>Objective: </i></b>The human serum metabolite profile is reflective of metabolic processes, including pathophysiological changes characteristic diseases. Therefore, investigation concentrations in obese children might give new insights into biological mechanisms associated with childhood obesity. <b><i>Methods: </i></b>Serum samples 80 and 40 normal-weight between 6 15 years age were analyzed using a mass spectrometry-based metabolomics...
Alcohol consumption is one of the world's major risk factors for disease development. But underlying mechanisms by which moderate-to-heavy alcohol intake causes damage are poorly understood and biomarkers sub-optimal. Here, we investigated metabolite concentration differences in relation to 2090 individuals KORA F4 replicated results 261 F3 up 629 females TwinsUK adult bioresource. Using logistic regression analysis adjusted age, body mass index, smoking, high-density lipoproteins...
Background Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition blood adult-populations is well established. We analyze this genetic-association two children-cohort-studies. In addition, association between variants FADS-gene-cluster and blood-fatty-acid-composition eczema was studied. Methods Principal Findings Data population-based-birth-cohorts Netherlands Germany (KOALA, LISA) were pooled (n = 879) analyzed by (logistic) regression regarding mutual...
Molecular adaptations in human non-alcoholic fatty liver disease (NAFLD) are incompletely understood. This study investigated the main gene categories related to hepatic de novo lipogenesis and lipid oxidation capacity.Liver specimens of 48 subjects were histologically classified according steatosis severity. In-depth analyses undertaken using real-time polymerase chain reaction, immunoblotting, immunohistochemistry. Lipid profiles analyzed by gas chromatography/flame ionization detection,...
Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory factor 1 (USF1) with blood lipid levels syndrome. USF1 is transcription APOA5. Methods: We investigated possible interaction between these two genes on the using data from German population-based KORA survey 4 (1,622 men women aged 55–74 years)....