A5035821203- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Bone health and osteoporosis research
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Bone and Joint Diseases
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Prostate Cancer Treatment and Research
- Advanced MRI Techniques and Applications
- Orthopaedic implants and arthroplasty
- Advanced X-ray and CT Imaging
- Medical Image Segmentation Techniques
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Shoulder Injury and Treatment
- Lung Cancer Research Studies
- Shoulder and Clavicle Injuries
- Medical Imaging and Analysis
- Acute Myocardial Infarction Research
- Bone health and treatments
- Lung Cancer Treatments and Mutations
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
Universidade Federal de Minas Gerais
2024
University Hospital Cologne
2011-2023
University of Cologne
2008-2023
Zentralklinik Bad Berka
2013-2022
University Hospital Ulm
2022
Schön Klinik Bad Aibling
2018
Philips (Germany)
2010-2017
University Hospital in Halle
2016
Technical University of Munich
2005-2014
Immundiagnostik (Germany)
2012
The objective of this study was to analyze the safety and efficacy <sup>177</sup>Lu-labeled DOTAGA-based prostate-specific membrane antigen (PSMA) ligand <sup>177</sup>Lu-DOTAGA-(I-y)fk(Sub-KuE) (<sup>177</sup>Lu-PSMA) in patients with metastatic castration-resistant prostate cancer (mCRPC). <b>Methods:</b> Fifty-six mCRPC underwent PSMA radioligand therapy (RLT) <sup>177</sup>Lu-PSMA....
Fibroblast activation protein (FAP) is a promising target for diagnosis and therapy of numerous malignant tumors. FAP-2286 the conjugate FAP-binding peptide, which can be labeled with radionuclides theranostic applications. We present first-in-human results using <sup>177</sup>Lu-FAP-2286 peptide-targeted radionuclide (PTRT). <b>Methods:</b> PTRT was performed in 11 patients advanced adenocarcinomas pancreas, breast, rectum ovary after prior confirmation uptake on...
To understand the determinants of troponin release in patients with stable coronary artery disease (CAD) by comparing high sensitive T (hsTnT) levels computed tomography angiography (CTA) characteristics atherosclerotic plaque.hsTnT was determined 124 consecutive angina, who underwent clinically indicated 256-slice CTA for suspected CAD. used to assess (1) calcification; (2) stenosis severity; (3) non-calcified plaque volume; (4) composition (soft or mixed, described as 'non-calcified'...
Peptide receptor radionuclide therapy (PRRT) of patients with somatostatin expressing neuroendocrine neoplasms has shown promising results in clinical trials and a recently published phase III study.In our center, 2294 were screened between 2004 2014 by 68Ga (SSTR) PET/CT. Intention to treat analysis included 1048 patients, who received at least one cycle 90Yttrium or 177Lutetium-based PRRT. Progression free survival was determined SSTR-PET/CT EORTC response criteria. Adverse events CTCAE...
A simple sodium chloride (NaCl) based (68)Ga eluate concentration and labeling method that enables rapid, high-efficiency of DOTA conjugated peptides in high radiochemical purity is described. The utilizes relatively few reagents comprises minimal procedural steps. It particularly well-suited for routine automated synthesis clinical radiopharmaceuticals. For the generator step, commercially available cation-exchange cartridges generators were used. was collected by use a strong cation...
The purposes of this study were to perform volumetric quantitative CT (QCT) the spine and hip using nondedicated contrast-enhanced standard MDCT data sets derive a conversion factor for bone mineral density (BMD) assessment based on dedicated QCT sets.Forty postmenopausal women with mean +/- SD age 71 9 years underwent routine abdominal pelvic MDCT. Before imaging examination, (L1-L3, n = 40) (n 21) was performed. Relations between findings assessed linear regression analysis.Mean lumbar BMD...
Purpose: PSMA-targeted radioligand therapy (PRLT) is a promising treatment option for patients with metastatic castration-resistant prostate cancer (mCRPC). However, high uptake of the radiopharmaceutical in salivary glands (SG) can lead to xerostomia and becomes dose-limiting 225Ac-PSMA-617. This study investigated sialotoxicity 177Lu-PSMA-I&T/-617 monotherapy co-administered 225Ac-PSMA-617 177Lu-PSMA-617 (Tandem-PPRLT). Methods: Three patient cohorts, that had undergone or Tandem-PRLT,...
Introduction Few longitudinal data about rates of bone loss in women midlife exist. Fewer still with their reproductive states having been carefully assessed and sequentially followed-up.
Quantification of the effect O-MAR on decreasing metal artefacts caused by large head total hip arthroplasty (MoM THA) in a dedicated phantom setup hip.Pathological reactions capsule Computed tomography (CT) can be difficult to diagnose due different artefacts. The algorithm deploys an iterative loop where sinogram is identified, extracted, and subsequently serves as mask correct measured sinogram. Main goal this study quantify ability technique deviation medullary bone attenuation streak...
Objectives We sought to investigate the association of epicardial adipose tissue (eCAT) volume with plaque burden, circulating biomarkers and cardiac outcomes in patients intermediate risk for coronary artery disease (CAD). Methods Results 177 consecutive outpatients at CAD completed biomarker analysis including high-sensitive Troponin T (hs-TnT) hs-CRP underwent 256-slice computed tomography angiography (CCTA) between June 2008 October 2011. Patients lumen narrowing ≥50% exhibited...