A5012940736- Retinal Diseases and Treatments
- Genetic Associations and Epidemiology
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Liver Disease Diagnosis and Treatment
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Inflammatory Bowel Disease
- Genetic and phenotypic traits in livestock
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Liver Disease and Transplantation
- Retinal Development and Disorders
- COVID-19 Clinical Research Studies
- Biosimilars and Bioanalytical Methods
- Autoimmune and Inflammatory Disorders Research
- Lipid metabolism and disorders
- Natural product bioactivities and synthesis
- Plant-Microbe Interactions and Immunity
- Microscopic Colitis
- SARS-CoV-2 and COVID-19 Research
- Ocular Diseases and Behçet’s Syndrome
- Monoclonal and Polyclonal Antibodies Research
- Folate and B Vitamins Research
Hallym University Sacred Heart Hospital
2013-2025
Yonsei University
2013-2025
Hallym University
2019-2024
Doheny Eye Institute
2018-2019
The Lundquist Institute
2013-2018
Harbor–UCLA Medical Center
2013-2018
Helmholtz Zentrum München
2017
University Medical Center Hamburg-Eppendorf
2017
Universität Hamburg
2017
German Centre for Cardiovascular Research
2017
Acute severe ulcerative colitis (UC) remains a significant clinical challenge and the ability to predict, at an early stage, those individuals risk of colectomy for medically refractory UC (MR-UC) would be major advance. The aim this study was use genome-wide association (GWAS) in well-characterized cohort patients identify genetic variation that contributes MR-UC.A GWAS comparing 324 MR-UC with 537 non-MR-UC analyzed using logistic regression Cox proportional hazards methods. In addition,...
The pathogenesis of polycystic ovary syndrome (PCOS) is poorly understood. PCOS-like phenotypes are produced by prenatal androgenization (PA) female rhesus monkeys. We hypothesize that perturbation the epigenome, through altered DNA methylation, one mechanisms whereby PA reprograms monkeys to develop PCOS. Infant and adult visceral adipose tissues (VAT) harvested from 15 10 control were studied. Bisulfite treated samples subjected genome-wide CpG methylation analysis, designed simultaneously...
Hypertension represents a major cardiovascular risk factor. The pathophysiology of increased blood pressure (BP) is not yet completely understood. Transcriptome profiling offers possibilities to uncover genetics effects on BP. Based 2 populations including 2549 individuals, meta-analyses monocytic transcriptome-wide profiles were performed identify transcripts associated with Replication was in independent studies whole-blood transcriptome data 1990 individuals. For identified candidate...
The ability to identify patients with Crohn's disease (CD) at highest risk of surgery would be invaluable in guiding therapy. Genome-wide association studies have identified multiple IBD loci unknown phenotypic consequences. aims this study were to: (1) associations between known and novel CD early resective (2) develop the best predictive model for time using a combination phenotypic, serologic, genetic variables. Genotyping was performed on 1,115 subjects Illumina-based genome-wide...
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases body weight, bleeding score and stool addition reversing DSS-induced mucosa destruction shortened colon. WKYMVm-induced effect against colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWW.W, indicating crucial role FPR2 effect. Mechanistically, effectively...
Objectives: This study aimed to predict the unknown etiology of fundus-obscuring vitreous hemorrhage (FOVH) based on preoperative conditions using machine learning (ML) and identify key factors. Methods: Medical records 223 eyes from 204 patients who underwent vitrectomy for FOVH between January 2012 July 2022 were retrospectively reviewed. Preoperative data, including demographic information, systemic disease, ophthalmic history, retinal status unaffected eye, collected. The postoperatively...
TMPRSS2 inhibitors used to prevent SARS-CoV-2 infection, which were screened from an Fv-antibody library.
Aim To evaluate changes in the ischaemic index (ISI) after targeted retinal photocoagulation (TRP) and to investigate correlation between these macular oedema (ME). Method Twenty-four eyes of 24 patients with vein occlusion (RVO) recurrent ME were included. Ultra-widefield fluorescein angiography (UWFFA; Optos 200Tx) was obtained at baseline every 4 months. The regions non-perfusion total gradable retina manually segmented on UWFFA images for calculating global ISI. ISI also computed...
A persistent hyaloid artery is a rare fetal remnant. Several complications such as amblyopia, vitreous hemorrhage, and retinal detachment have been reported. Here, we present case of hemorrhage with artery. healthy 16-year-old male presented blurred vision in his left eye. Vitreous occurred absorbed spontaneously. Slit-lamp examination demonstrated Mittendorf's dot fundus revealed Optical coherence tomography (OCT) showed Bergmeister's papilla. The blood flow the via papilla was found by OCT...
Abstract Although phospholipase C (PLC) is a crucial enzyme required for effective signal transduction and leukocyte activation, the role of PLC in polymicrobial sepsis remains unclear. In this study, we show that direct activator m-3M3FBS treatment significantly attenuates vital organ inflammation, widespread immune cell apoptosis, mortality mouse model induced by lethal cecal ligation puncture challenge. Mechanistically, m-3M3FBS–dependent protection was largely abolished pretreatment mice...
Objective To compare systemic conditions at the time of diagnosis between patients with central retinal vein occlusion (CRVO) and branch (BRVO). Design This study included diagnosed CRVO or BRVO February 2009 August 2017 three hospitals Hallym University Medical Center. Demographic anthropometric variables, comorbidity profiles, laboratory findings were collected from a clinical data warehouse system, compared groups. Result Four hundred seventeen 1,511 included. The mean age was 61.8 ± 13.9...
Branch retinal artery occlusion (BRAO) and branch vein (BRVO) rarely cause neovascular glaucoma (NVG). A 58-year-old woman with hypertension type 2 diabetic mellitus complained of progressive visual loss in her right eye for the previous 3 months. At initial examination, acuity was 20 / 63 eye. Angle neovascularization observed intraocular pressure (IOP) 30 mmHg Fundus examination fluorescein angiography showed BRAO combined BRVO. We immediately injected intravitreal intracameral bevacizumab...
ABSTRACT Background and Objectives: Nonalcoholic fatty liver disease (NAFLD) disproportionately affects Hispanic boys. Further, obesity insulin resistance are major risk factors for NAFLD. No gene localization studies had been performed on children with biopsy‐proven This study aims to identify genomic variants associated increased adiposity in a population of varying histologic severity Methods: We conducted genome‐wide association scan (GWAS) including 624,297 single‐nucleotide...
We evaluate the repeatability of fluorescence lifetime imaging ophthalmoscopy (FLIO) in normal subjects with mydriasis and explore factors that influence FLIO imaging.Thirty-two healthy participants (63 eyes) were enrolled this prospective study. The Heidelberg Engineering system uses a 473 nm blue laser light emitted is detected two wavelength channels, short long spectral channels (SSC, LSC). mean (τm) values computed for entire scan area as well five regions interest (ROI, 1 × mm) at...
We characterized the expression pattern of Atropa belladonna salicylic acid (SA) carboxyl methyltransferase gene, AbSAMT1, encoding S-adenosyl-L-methionine (SAM): SA (SAMT) in A. belladonna, after application biotic and abiotic stresses to plants. AbSAMT1 was expressed treatments exogenous also 1,2-benzisothiazole-1,1-dioxide (BIT), which is a chemical inducer related SA-dependent response. Expression gene induced by infection plants with Pseudomonas syringae pv. tabaci (Pst), when...
We investigated whether a deep learning algorithm applied to retinal fundoscopic images could predict cerebral white matter hyperintensity (WMH), as represented by modified Fazekas scale (FS), on brain magnetic resonance imaging (MRI).Participants who had undergone MRI and health-screening fundus photography at Hallym University Sacred Heart Hospital between 2010 2020 were consecutively included. The subjects divided based the presence of WMH, then classified into three groups according FS...
Fv-antibodies targeting the proprotein convertase (PPC) region of SARS-CoV-2 spike protein (SP) were screened from an Fv-antibody library to inhibit infection. Two selected expressed as soluble recombinant proteins, and their binding affinities assessed using a surface plasmon resonance biosensor. The regions these corresponded cleavage sites furin (S1/S2) transmembrane serine protease 2 (TMPRSS2, S2'). neutralizing activities two demonstrated cell-based infection assay with pseudo-viruses...