André Karch
A5083896047- COVID-19 epidemiological studies
- Global Maternal and Child Health
- Prion Diseases and Protein Misfolding
- Health disparities and outcomes
- SARS-CoV-2 and COVID-19 Research
- Global Health Care Issues
- Health Systems, Economic Evaluations, Quality of Life
- Global Public Health Policies and Epidemiology
- Acute Ischemic Stroke Management
- Climate Change and Health Impacts
- COVID-19 and Mental Health
- Respiratory viral infections research
- Child Nutrition and Water Access
- Vaccine Coverage and Hesitancy
- Forensic Anthropology and Bioarchaeology Studies
- Sepsis Diagnosis and Treatment
- Health and Medical Studies
- Insurance, Mortality, Demography, Risk Management
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Cerebrovascular and Carotid Artery Diseases
- Pediatric health and respiratory diseases
- Bacterial Identification and Susceptibility Testing
- Global Cancer Incidence and Screening
- Gut microbiota and health
University of Münster
2019-2025
Institute for Health Metrics and Evaluation
2016-2024
University Hospital Münster
2020-2024
University of Washington
2016-2024
University Hospital of Oran
2024
Natural and Medical Sciences Institute
2023
University of Tübingen
2023
Institut für Soziale Arbeit
2023
University of Southern Denmark
2023
Helmholtz Centre for Infection Research
2013-2022
BackgroundThe number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challenges requires an accurate understanding disease burden. We aimed present first detailed analysis global prevalence, mortality, overall burden as captured by Global Burden Diseases, Injuries, Risk Factors (GBD) Study 2016, highlight most important messages for clinicians neurologists.MethodsGBD 2016...
Comparable data on the global and country-specific burden of neurological disorders their trends are crucial for health-care planning resource allocation. The Global Burden Diseases, Injuries, Risk Factors (GBD) Study provides such information but does not routinely aggregate results that interest to clinicians specialising in conditions. In this systematic analysis, we quantified disease due 2015 its relationship with country development level.We estimated prevalence, mortality,...
The literature focuses on mortality among children younger than 5 years. Comparable information nonfatal health outcomes these and the fatal burden of diseases injuries older adolescents is scarce.
BackgroundAlthough the burden of influenza is often discussed in context historical pandemics and threat future pandemics, every year a substantial lower respiratory tract infections (LRTIs) other conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden Disease Study (GBD) 2017 systematic scientific effort quantify health loss associated with comprehensive set diseases disabilities. In this Article, we focus on LRTIs that can be...
Given the key role of butyrate for host health, understanding ecology intestinal butyrate-producing communities is a top priority gut microbiota research. To this end, we performed pooled analysis on 2,387 metagenomic/transcriptomic samples from 15 publicly available data sets that originated three continents and encompassed eight diseases as well specific interventions. For analyses, gene catalogue was constructed gene-targeted assemblies all genes synthesis pathways an updated reference...
Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide comprehensive assessment of the levels trends global burden that could help guide introduction, continuation, ongoing development vaccines treatment programmes.
Reliability of measurements is a prerequisite medical research. For nominal data, Fleiss' kappa (in the following labelled as K) and Krippendorff's alpha provide highest flexibility available reliability measures with respect to number raters categories. Our aim was investigate which confidence intervals best statistical properties for assessment inter-rater in different situations.We performed large simulation study precision estimates K determine empirical coverage probability...
Real-time quaking-induced conversion (RT-QuIC) allows the amplification of miniscule amounts scrapie prion protein (PrP(Sc)). Recent studies applied RT-QuIC methodology to cerebrospinal fluid (CSF) for diagnosing human diseases. However, date, there has not been a formal multi-centre assessment reproducibility, validity and stability in this context, an indispensable step establishment as diagnostic test clinical practice. In present study, we analysed CSF from 110 disease patients 400...
Many countries have shown marked declines in diarrhoeal disease mortality among children younger than 5 years. With this analysis, we provide updated results on years from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) use study's comparative risk assessment to quantify trends effects factors, interventions, broader sociodemographic development changes 195 territories 1990 2017.This analysis for GBD had three main components. Diarrhoea was modelled using...
Disability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD among adolescents remains poorly described in EU.Estimates were retrieved from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019. Causes NCDs analysed at three different levels GBD 2019 hierarchy, for which mortality, years life lost (YLLs), lived with disability (YLDs), disability-adjusted life-years (DALYs) extracted. Estimates, 95% uncertainty intervals (UI), EU Member...
The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection prevention disease. Specifically, NAKO designed novel better characterize established protection for development cardiovascular cancer, diabetes, neurodegenerative psychiatric musculoskeletal respiratory infectious diseases in random sample general population. Between 2014 2019, total...
To date, cerebrospinal fluid analysis, particularly protein 14-3-3 testing, presents an important approach in the identification of Creutzfeldt–Jakob disease cases. However, one special point criticism testing is specificity differential diagnosis rapid dementia. The constant observation increased referrals national surveillance centres over last years raises concern declining due to higher number tests performed various neurological conditions. Within framework a European Community...
<h3>Importance</h3> Randomized clinical trials have shown the efficacy of thrombectomy large intracranial vessel occlusions in adults; however, any association therapy with outcomes children is unknown. <h3>Objective</h3> To evaluate use endovascular recanalization pediatric patients arterial ischemic stroke. <h3>Design, Setting, and Participants</h3> This retrospective, multicenter cohort study, conducted from January 1, 2000, to December 31, 2018, analyzed databases 27 stroke centers...
To revise the German guidelines and recommendations for ensuring Good Epidemiological Practice (GEP) that were developed in 1999 by Society Epidemiology (DGEpi), evaluated revised 2004, supplemented 2008, updated 2014. The executive board of DGEpi tasked third revision GEP. was arrived as a result consensus-building process working group collaboration with other groups Association Medical Informatics, Biometry Epidemiology, Social Medicine Prevention (DGSMP), Region International Biometric...
Abstract Background Projection of future cancer incidence is an important task in epidemiology. The results are interest also for biomedical research and public health policy. Age-Period-Cohort (APC) models, usually based on long-term registry data (> 20 yrs), established such projections. In many countries (including Germany), however, nationwide not yet available. General guidance statistical approaches projections using rather short-term challenging software to enable researchers...
The development of in vitro amplification systems allows detecting femtomolar amounts prion protein scrapie (PrPSc) human cerebrospinal fluid (CSF). We performed a CSF study to determine the effects disease type, codon 129 genotype, PrPSc and other disease-related factors on real-time quaking-induced conversion (RT-QuIC) response. analyzed times 10,000 relative fluorescence units, areas under curve signal maximum RT-QuIC response as seeding parameters interest. Interestingly, type (sporadic...
It is becoming evident that certain features of human microbiota, encoded by distinct autochthonous taxa, promote disease. As a result, borders between the so-called opportunistic pathogens, pathobionts, and commensals are increasingly blurred, specific targets for manipulating microbiota to improve host health elusive. In this study, we focus on functions bacterial communities have potential cause disease, proposing term “pathogenic function (pathofunction)”. The concept presented via three...
Abstract The humoral immune response to SARS-CoV-2 is a benchmark for immunity and detailed analysis required understand the manifestation progression of COVID-19, monitor seroconversion within general population, support vaccine development. majority currently available commercial serological assays only quantify antibody against individual antigens, limiting our understanding response. To overcome this, we have developed multiplex immunoassay (MultiCoV-Ab) including spike nucleocapsid...
Men and women are differently affected by acute ischemic stroke (AIS) in many aspects. Prior studies on sex disparities were limited moderate sample sizes, varying years of data acquisition, inconsistent inclusions covariates leading to controversial findings. We aimed analyze differences AIS severity, treatments, early outcome systematically evaluate the effect important a large German registry.Analyses based Stroke Registry Northwestern Germany from 2000 2018. focused admission-stroke...
Numerous studies have reported an increase in mental disorders during the COVID-19 pandemic, but exact reasons for this development are not well understood. In study we investigate whether pandemic-related occupational and financial changes (e.g., reduced working hours, from home, losses) were associated with increased symptoms of depression anxiety compared situation before pandemic.We analyzed data German National Cohort (NAKO) Study. Between May November 2020, 161 849 participants...