A5028903791- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Agriculture and Rural Development Research
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Liver Disease and Transplantation
- EEG and Brain-Computer Interfaces
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Ion channel regulation and function
- Colorectal Cancer Surgical Treatments
- ECG Monitoring and Analysis
- Cardiomyopathy and Myosin Studies
- Intensive Care Unit Cognitive Disorders
- Advanced MRI Techniques and Applications
- Viral Infections and Immunology Research
- Health and Medical Studies
- Venous Thromboembolism Diagnosis and Management
- Asymmetric Hydrogenation and Catalysis
- Hemodynamic Monitoring and Therapy
Heinrich Heine University Düsseldorf
2015-2025
Heart Rhythm Society
2025
North Shore University Hospital
2025
German Centre for Cardiovascular Research
2015-2024
Düsseldorf University Hospital
2013-2024
University Cancer Center Hamburg
2016-2024
University Hospital Bonn
2005-2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Evangelisches Krankenhaus Düsseldorf
2020-2023
Abstract Aims Treatment guidelines for patients with atrial fibrillation (AF) suggest that should be managed an antiarrhythmic drug (AAD) before undergoing catheter ablation (CA). This study evaluated whether pulmonary vein isolation employing cryoballoon CA is superior to AAD therapy the prevention of arrhythmia (AA) recurrence in rhythm control naive paroxysmal AF (PAF). Methods and results A total 218 treatment symptomatic PAF were randomized (1 : 1) (Arctic Front Advance, Medtronic) or...
Catheter ablation for ventricular tachycardia (VT) reduces the recurrence of VT in patients with implantable cardioverter-defibrillators (ICDs). The appropriate timing and its effects on mortality heart failure progression remain a matter debate. In life-threatening arrhythmias necessitating ICD implantation, we compared outcomes preventive (undertaken before implantation to prevent shocks VT) deferred after 3 VT. BERLIN study (Preventive Ablation Ventricular Tachycardia Patients With...
Aging is a major risk factor for impaired cardiovascular health. Because the aging myocardium characterized by microcirculatory dysfunction, and because nerves align with vessels, we assessed impact of on cardiac neurovascular interface. We report that reduces nerve density in ventricle dysregulates vascular-derived neuroregulatory genes. down-regulates microRNA 145 (miR-145) derepresses neurorepulsive semaphorin-3A. miR-145 deletion, which increased
Electrical storm (ES) is a state of electrical instability, manifesting as recurrent ventricular arrhythmias (VAs) over short period time (three or more episodes sustained VA within 24 h, separated by at least 5 min, requiring termination an intervention). The clinical presentation can vary, but ES usually cardiac emergency. mainly affects patients with structural primary heart disease, often implantable cardioverter-defibrillator (ICD). Management requires multi-faceted approach and the...
Abstract Objective We aimed to assess the effect of SGLT2i on arrhythmias by conducting a meta-analysis using data from randomized controlled trials(RCTs). Background Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have shown cardioprotective effects via multiple mechanisms that may also contribute decrease risk. Methods searched in databases (PubMed, Embase, Cochrane Library, and clinicaltrials.gov) up April 2023. RCTs comparing with placebo were included. The atrial fibrillation(AF),...
The formation of factor VIII antibodies is a major problem for replacement therapy haemophilia A patients. Antibodies occur in 5-30% patients with severe A. reason antibody still unknown. In this study we correlate the first time different gene mutations, stop- and missense large small deletions intrachromosomal intron 22 recombinations to formation. total 364 known inhibitor status our institute, database, 3 studies representing intron-22-inversion data are included. results show that risk...
The optimal treatment for patients with atrial fibrillation (AF) and heart failure (HF) has been a subject of debate years. We aimed to evaluate the efficacy safety rhythm control strategy in AF complicated HF regarding hard clinical endpoints.Up-to-date randomized data comparing using antiarrhythmic drugs (AADs) vs. rate (Subset A) or catheter ablation medical therapy B) were pooled. primary outcomes all-cause mortality, re-hospitalization, stroke, thromboembolic events. A total 11 studies...
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and unique research platform network to obtain substantial knowledge about several important risk prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 74 years age from the general population Hamburg, Germany, are taking part an extensive baseline assessment at one dedicated center. Participants undergo 13 validated 5 novel examinations primarily...
Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease accompanied by structural and contractile alterations. We identified rare c.740C>T (p.T247M) mutation in ACTN2, encoding α-actinin 2 HCM patient, who presented with left ventricular hypertrophy, outflow tract obstruction, atrial fibrillation. generated patient-derived human-induced pluripotent stem cells (hiPSCs) show that hiPSC-derived cardiomyocytes engineered heart tissues recapitulated several hallmarks of HCM, such as...
Background Identification and elimination of nonpulmonary vein targets may improve clinical outcomes in patients with persistent atrial fibrillation (AF). We report on the use a novel, noncontact imaging mapping system that uses ultrasound to reconstruct chamber anatomy measures timing density dipolar, ionic activation (ie, charge density) across myocardium guide ablation arrhythmias. Methods The prospective, nonrandomized UNCOVER AF trial (Utilizing Novel Dipole Density Capabilities...
Abstract The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming therapy choice for This inevitably associated with obliteration cholinergic neurons. However, impact on ventricular electrophysiology unclear. Here we show that neurons modulate electrophysiology. Mechanical disruption or pharmacological blockade innervation...
To explore technical challenges of phase singularity (PS) mapping during atrial fibrillation (AF) using direct contact electrograms.AF was performed in high-density epicardial recordings human paroxysmal (PAF) or persistent (PersAF) (N = 20 pts) AF with an array 16 × electrodes placed on epicardium. PS points were detected subsets forming rings varying sizes.PS detection a 2 electrode ring identified 0.88 ± 1.00 PS/s PAF group and 3.91 2.51 per s PersAF (p < 0.001) 2.4 cm area. All had short...
Ventricular tachycardia (VT) with structural heart disease is dependent on reentry within scar regions. We set out to assess the VT circuit in greater detail than has hitherto been possible, using ultra-high-density mapping.All mapping guided ablation cases from 6 high-volume European centers were assessed. Maps analyzed offline generate activation maps of circuits. Topography, conduction velocity, and voltage complete maps.Thirty-six tachycardias 31 patients identified, 29 male 27 ischemic....
Radiofrequency ablation creates irreversible cardiac damage through resistive heating and this temperature change results in a generator impedance drop. Evaluation of novel local (LI) technology measured exclusively at the tip catheter found that larger LI drops were indicative more effective lesion formation. We aimed to evaluate whether drop is associated with conduction block patients paroxysmal atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI).Sixty underwent LI-blinded...
Weight management seems to be beneficial for obese atrial fibrillation (AF) patients; however, randomized data are sparse. Thus, this study aimed investigate the influence of weight reduction on AF ablation outcomes.SORT-AF is an investigator-sponsored, prospective, randomized, multicentre, and clinical trial. Patients with symptomatic (paroxysmal or persistent) body mass index (BMI) 30-40 kg/m2 underwent were either weight-reduction (group 1) usual care 2), after sleep-apnoea-screening loop...