A5068836382- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Vagus Nerve Stimulation Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- EEG and Brain-Computer Interfaces
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Pain Management and Treatment
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Neurological disorders and treatments
- Neuropeptides and Animal Physiology
- Blood Pressure and Hypertension Studies
- Medical Imaging and Pathology Studies
- Case Reports on Hematomas
- Hepatitis C virus research
University of California, Los Angeles
2016-2025
UCLA Health
2013-2024
Texas Cardiac Arrhythmia
2015-2024
UCLA Medical Center
2024
Case Western Reserve University
2023
Heart Rhythm Society
2022
Ronald Reagan UCLA Medical Center
2010-2020
Center for Excellence in Education
2020
Shahid Chamran University of Ahvaz
2018
Centro Cardiologico Monzino
2017
Background— Reducing sympathetic output to the heart from neuraxis can protect against ventricular arrhythmias. The purpose of this study was assess value thoracic epidural anesthesia (TEA) and left cardiac denervation (LCSD) in management arrhythmias patients with structural disease. Methods Results— Clinical data 14 (25 75 years old, mean±SD 54.2±16.6 years; 13 men) who underwent TEA, LCSD, or both control tachycardia (VT) refractory medical therapy catheter ablation were reviewed. Twelve...
Electrical storm (ES) is a state of electrical instability, manifesting as recurrent ventricular arrhythmias (VAs) over short period time (three or more episodes sustained VA within 24 h, separated by at least 5 min, requiring termination an intervention). The clinical presentation can vary, but ES usually cardiac emergency. mainly affects patients with structural primary heart disease, often implantable cardioverter-defibrillator (ICD). Management requires multi-faceted approach and the...
It is not known whether the most delayed late potentials are functionally specific for scar-related ventricular tachycardia (VT) circuits.Isochronal activation maps were constructed to display during sinus rhythm over 8 isochrones. Analysis was performed at successful VT termination sites and prospectively tested. Thirty-three patients with 47 VTs where a critical site demonstrated by of ablation retrospectively analyzed. In those who underwent mapping multiple surfaces, 90% on surface that...
In patients referred for radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in the setting structural heart disease, early post-procedural mortality (EM) has not been previously investigated. The purpose this study was to evaluate EM after scar-related VT. Associations between clinical and procedural variables (within 31 days procedure) were tested with disease undergoing RFCA VT at 12 international centers. Of 2,061 (mean age 62 ± 13 years; left ejection fraction [LVEF]...
Key points Intrinsic cardiac (IC) neurons undergo differential morphological and phenotypic remodelling that reflects the site of myocardial infarction (MI). Afferent neural signals from infarcted region to IC are attenuated, while those border remote regions preserved post‐MI, giving rise a ‘neural sensory zone’. Convergent local circuit (processing) have enhanced transduction capacity following MI. Functional network connectivity within intrinsic nervous system is reduced post‐MI. MI...
The sympathetic nervous system is thought to play a key role in genesis and maintenance of ventricular arrhythmias. myocardial effect stimulation on repolarization humans poorly understood. purpose this study was evaluate the effects direct reflex patients with postinfarct cardiomyopathy (ICM). were assessed using isoproterenol, while those nitroprusside infusion ICM (n = 5). Five without also studied. Local measured from intracardiac electrograms that used calculate activation recovery...
To propose and test a modified wideband late gadolinium enhancement (LGE) magnetic resonance (MR) imaging technique to overcome hyperintensity image artifacts caused by implanted cardiac devices.Written informed consent was obtained from all participants, the HIPAA-compliant study protocol approved institutional review board. Studies in phantoms healthy volunteer were performed hypothesis that are typically observed on LGE images patients with devices insufficient inversion of affected...
Background— T-peak to T-end interval (Tp-e) is an independent marker of sudden cardiac death. Modulation Tp-e by sympathetic nerve activation and circulating norepinephrine not well understood. The purpose this study was characterize endocardial epicardial dispersion repolarization (DOR) its effects on with activation. Methods Results— In Yorkshire pigs (n=13), a sternotomy performed the heart bilateral stellate ganglia were exposed. A 56-electrode sock 64-electrode basket catheter placed...
Novel therapies aimed at modulating the autonomic nervous system, including thoracic epidural anesthesia (TEA), have been shown in small case series to be beneficial treating medically refractory ventricular tachycardia (VT) storm. However, it is not clear when these options should considered. We reviewed a multicenter experience with TEA management of VT storm determine its optimal therapeutic use.Data for 11 patients whom was instituted between July 2005 and March 2016 were clinical...