A5073236490- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Disaster Response and Management
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Electrostatic Discharge in Electronics
- Nursing Roles and Practices
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diamond and Carbon-based Materials Research
- Coronary Artery Anomalies
LMU Klinikum
2015-2025
Ludwig-Maximilians-Universität München
2016-2025
German Centre for Cardiovascular Research
2021-2025
München Klinik
2024
Johns Hopkins University
2024
Haukeland University Hospital
2014
University of Bergen
2014
Deutsches Herzzentrum München
2005-2013
Technical University of Munich
2005-2013
Klinikum rechts der Isar
2006-2011
Ablation of persistent atrial fibrillation (AF) remains a challenge. Left fibrosis plays an important role in the pathophysiology AF and has been associated with poor procedural outcomes.To investigate efficacy adverse events targeting detected on magnetic resonance imaging (MRI) reducing arrhythmia recurrence AF.The Efficacy Delayed Enhancement-MRI-Guided Fibrosis vs Conventional Catheter Atrial Fibrillation trial was investigator-initiated, multicenter, randomized clinical involving 44...
Abstract There is an increasing proportion of the general population surviving to old age with significant chronic disease, multi-morbidity, and disability. The prevalence pre-frail state frailty syndrome increases exponentially advancing associated greater morbidity, disability, hospitalization, institutionalization, mortality, health care resource use. Frailty represents a global problem, making early identification, evaluation, treatment prevent cascade events leading from functional...
To investigate the incidence, electrophysiological properties, and ablation results for left atrial (LA) tachycardia as a sequel to circumferential pulmonary vein (CPVA) fibrillation (AF).Sixty-seven patients with AF underwent CPVA. Sustained LA developed in 21/67 (31%) 16/21 symptomatic 55 tachycardias (3.4+/-2.4 per patient) were mapped: 18 (33%) related macro-re-entry around mitral valve (7) or vein(s) (11). In 20 (36%), 'small-loop' re-entrant (LART) was identified; gaps prior lines (7...
Cryoablation has emerged as an alternative to radiofrequency catheter ablation (RFCA) for the treatment of atrioventricular (AV) nodal reentrant tachycardia (AVNRT). The purpose this prospective randomized study was test whether cryoablation is effective RFCA during both short-term and long-term follow-up with a lower risk permanent AV block.A total 509 patients underwent slow pathway (n=251) or (n=258). primary end point immediate failure, block, AVNRT recurrence 6-month follow-up....
Aims The aim of the study was to investigate feasibility performing segmental pulmonary vein (PV) isolation guided by NavX®(Endocardial Solutions, St Jude Medical, Inc., Paul, MN, USA) system without three-dimensional (3D) geometric reconstruction option and whether use NavX will reduce radiation exposure procedure duration. Methods results included 64 patients with symptomatic paroxysmal or permanent atrial fibrillation, in whom PV performed using fluoroscopic guidance (n=32) (n=32)....
The aim of this European Heart Rhythm Association (EHRA) survey was to assess clinical practice in relation the tools and techniques used for cardiac implantable electronic devices procedures countries. Responses questionnaire were received from 62 members EHRA research network. involved high-, medium-, low-volume implanting centres, performing, respectively, more than 200, 100–199 under 100 implants per year. following topics explored: side approach implantation, surgical pocket incision,...
Predictors of atrioventricular nodal reentrant tachycardia (AVNRT) recurrence after radiofrequency ablation including the importance residual slow pathway conduction are not known. The aim this study was to report acute and long-term results in a large series consecutive patients with AVNRT analyze potential predictors arrhythmia particular emphasis on ablation.The included 506 (mean age 52.6 +/- 16 years, 315 women) who underwent using combined electrophysiological anatomical approach. end...
Pulmonary vein isolation (PVI) is an established treatment for paroxysmal atrial fibrillation (AF). The ablation of complex fractionated electrograms (CFAE) has emerged as a novel approach. We sought to evaluate the additional effect CFAE PVI in AF.Ninety-eight patients with AF (57 +/- 10 years, 74 male) were randomized (n = 48) or + group 50). After PVI, was performed inducible group. primary endpoint combined objective (7-day Holter ECG) and subjective (symptoms) freedom tachyarrhythmia 3...
Introduction: Complex fractionated atrial electrograms (CFAE) have been described as a new target for ablation of fibrillation (AF). This prospective study evaluates the acute effects CFAE in patients with paroxysmal or persistent AF and analyzes preferential anatomic sites where these occur. Methods Results: Ablation was performed 66 symptomatic (mean age 58 ± 12 years) (n = 36) 30). Termination regularization during achieved 56 (84%), termination 28 (42%) (42%). showed no effect 10 (16%)....
Ablation of left atrial flutter (LAF) is often limited by the need for technically demanding linear lesions. We evaluated safety and efficacy a new modified anterior line (MAL), connecting anterior/anterolateral mitral annulus with superior pulmonary vein ablation perimitral flutter.MAL was performed in 65 patients (15 females, age 63.6 +/- 9.8 years) using 3D mapping systems (70.8% Carto, 29.2% NavX). Perimitral either presenting arrhythmia (73.8%) or an intermediate organized rhythm during...
Quality of Life After Ablation for Atrial Fibrillation. Background : This study prospectively assesses different aspects short‐ and long‐term quality life (QoL) after catheter ablation atrial fibrillation (AF). An analysis 7 validated generic tailored questionnaires was performed with regard to the relation QoL success. Methods The included 133 patients (74% men, age 57±10) who underwent pulmonary vein isolation ± linear or electrogram‐guided substrate modification AF. quantitatively...
The purpose of this European Heart Rhythm Association survey was to assess the attitude, level education, and knowledge concerning oral anticoagulants (OACs) among patients with atrial fibrillation (AF) taking vitamin K antagonists (VKAs), non-VKA (NOACs) or antiplatelets. A total 1147 AF [mean age 66 ± 13 years, 529 (45%) women] from 8 selected countries responded survey. overall use OACs antiplatelets 77 15.3%, respectively. Of OACs, 67% were on VKAs, 33% NOACs, 17.9% a combination Among...
Background: Complex fractionated atrial electrograms (CFAE) are a possible target for fibrillation (AF) ablation and can be visualized in three‐dimensional (3D) mapping systems with specialized software. Objective: To use the new CFAE software of CartoXP® (Biosense Webster, Diamond Bar, CA, USA) analysis spatial distribution paroxysmal persistent AF. Methods: We included 16 consecutive patients (6 females; mean 59.3 years) AF 10 persistent) undergoing ablation. Carto maps left atrium (LA)...
BackgroundCardiac autonomic dysfunction after myocardial infarction identifies patients at high risk despite only moderately reduced left ventricular ejection fraction. We aimed to show that telemedical monitoring with implantable cardiac monitors in these can improve early detection of subclinical but prognostically relevant arrhythmic events.MethodsWe did a prospective investigator-initiated, randomised, multicentre, open-label, diagnostic trial 33 centres Germany and Austria. Survivors...
This study provides an update of survey-based data providing overview interventional electrophysiology over the last decade. Overall infrastructure, procedures, and training opportunities in Germany were assessed.By analyzing mandatory quality reports, German cardiology centres performing electrophysiological studies identified to repeat a questionnaire from 2010 2015.A complete was returned by 192 centers about 75% all ablations 2020. In presence COVID-19 pandemic, total 76.304 procedures...
Background: Catheter ablation of complex fractionated atrial electrograms (CFAE) for persistent fibrillation (AF) is a promising treatment strategy. We tested the hypothesis that CFAE superior to linear in patients with or long‐standing AF. Methods: In this study, 116 AF were randomly assigned undergo circumferential PVI plus additional lines (linear group; 59 patients) ostial pulmonary vein isolation (PVI) (spot 57 patients). Primary endpoint was freedom from tachyarrhythmia after single...
The European Snapshot Survey on Procedural Routines in Atrial Fibrillation Ablation (ESS-PRAFA) is a prospective, multicentre snapshot survey of patients undergoing atrial fibrillation (AF) ablation, conducted to collect patient-based data current clinical practices AF ablation context the latest Guidelines and contemporary oral anticoagulant therapies. EP Research Network Centres were asked prospectively enrol consecutive during 6-week period (September/October 2014). Data collected via...
Management of patients with non-valvular atrial fibrillation (AF) presenting an acute coronary syndrome (ACS) may be particularly challenging. Given the lack sound evidence-based recommendations for management such patients, aim this European Heart Rhythm Association survey was to provide insight into current practice in Europe regarding these patients. Overall, 41 centres submitted a valid response. The majority respondents were university hospitals (85%). has shown that principal aspects...