A5071990686- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Viral Infections and Immunology Research
- Acute Myocardial Infarction Research
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- Sensory Analysis and Statistical Methods
- Pregnancy and preeclampsia studies
- Nitric Oxide and Endothelin Effects
- Infective Endocarditis Diagnosis and Management
- Face recognition and analysis
- Eicosanoids and Hypertension Pharmacology
- Advanced Memory and Neural Computing
- Neural Networks and Reservoir Computing
- Ultrasound and Hyperthermia Applications
- Peptidase Inhibition and Analysis
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Emotion and Mood Recognition
- Enzyme function and inhibition
- Pharmacogenetics and Drug Metabolism
University Medical Center Hamburg-Eppendorf
2018-2024
Universität Hamburg
2018-2023
Eppendorf (Germany)
2022
GTx (United States)
2021
Universities of Giessen and Marburg Lung Center
2016-2019
German Center for Lung Research
2016-2019
Universitat Pompeu Fabra
2014
Drexel University
1987
CMR feature tracking strain (CMR-FT) provides prognostic information. However, there is a paucity of data in hypertrophic cardiomyopathy (HCM). We sought to analyze global CMR-FT parameters all four cardiac chambers and assess associations with NT-proBNP troponin T (hsTnT) patients HCM.This retrospective study included 144 HCM 16 healthy controls at 1.5 T. Analyses were performed on standard steady-state free precession cine (SSFP) using commercially available software. Global left...
Abstract Strain is an important imaging parameter to determine myocardial deformation. This study sought 1) assess changes in left ventricular strain and ejection fraction (LVEF) from acute chronic ST-elevation infarction (STEMI) 2) analyze as a predictor of late gadolinium enhancement (LGE). 32 patients with STEMI 18 controls prospectively underwent cardiac magnetic resonance imaging. Patients were scanned 8 $$\pm$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML">...
The purpose of this work is to describe the objectives and design cardiovascular magnetic resonance (CMR) imaging in single center, prospective, population-based Hamburg City Health study (HCHS). HCHS aims at improving risk stratification for coronary artery disease (CAD), atrial fibrillation (AF) heart failure (HF). will finally include 45,000 inhabitants city (Germany) between 45 74 years who undergo an extensive evaluation collection biomaterials. Risk-scores CAD, AF HF are used create...
Background: Reliable reference intervals are crucial for clinical application of myocardial T1 and T2 mapping cardiovascular magnetic resonance imaging. This study evaluated the impact sex risk factors on T1, extracellular volume fraction (ECV), at 3T in population-based HCHS (Hamburg City Health Study). Methods: The final sample consisted 1576 consecutive participants between 46 78 years without prevalent heart disease, including 1020 (67.3%) with hypertension 110 (7.5%) diabetes. were...
The presence of myocardial scar is associated with poor prognosis in several underlying diseases. Late-gadolinium-enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging reveals clinically silent "unrecognized scar" (UMS), but the etiology UMS often remains unclear. This population-based CMR study evaluated prevalence, localization, patterns, and risk factors UMS.
Abstract Objectives The study aimed to investigate the alterations of myocardial deformation responding long-standing pressure overload and effects focal fibrosis using feature-tracking cardiac magnetic resonance (FT-CMR) in patients with resistant hypertension (RH). Methods Consecutive RH were prospectively recruited underwent CMR at a single institution. FT-CMR analyses based on cine images applied measure left ventricular (LV) peak systolic global longitudinal (GLS), radial (GRS),...
Abstract Objectives Parametric cardiac magnetic resonance (CMR) techniques have improved the diagnosis of pathologies. However, primary tool for differentiating non-ST elevation myocardial infarction (NSTEMI) from myocarditis is still a visual assessment conventional signal-intensity-based images. This study aimed at analyzing ability parametric compared to visually differentiate ischemic non-ischemic injury patterns. Methods Twenty NSTEMI patients, twenty infarct-like and controls were...
Parametric mapping constitutes a novel cardiac magnetic resonance (CMR) technique enabling quantitative assessment of pathologic alterations left ventricular (LV) myocardium. This study aimed to investigate the clinical utility techniques with and without contrast agent compared standard CMR predict adverse LV remodeling following acute myocardial infarction (AMI).
Follow-up after acute myocarditis is important to detect persisting myocardial dysfunction. However, recovery of atrial function has not been evaluated so far. Thirty-five patients with strictly defined underwent cardiovascular magnetic resonance (CMR, 1.5 T) in the stage at baseline (BL) and 3 months follow-up (FU). The study population included 13 biopsy-proven "cardiomyopathy-like" (CLM) 22 "infarct-like" (ILM) clinical presentation. CMR feature tracking (FT) was performed on conventional...
There is a paucity of data on cardiovascular magnetic resonance feature tracking (CMR-FT) in patients with dilated cardiomyopathy (DCM). We aimed at describing global and segmental myocardial strain patterns potential association the presence focal scarring DCM by CMR-FT.Thirty-nine reduced left ventricular (LV) ejection fraction (mean 21±8%) underwent CMR including standard cine steady-state free precession (SSFP) sequences late gadolinium enhancement (LGE). measured LV longitudinal as well...
Schneider, Jan Niklas; Neumann, Johannes Tobias; Bohnen, Sebastian; Sörensen, Nils Arne; Cavus, Ersin; Schäfer, Sarina; Hartikainen, Tau Sarra; Goßling, Alina; Tahir, Enver; Lund, Gunnar K.; Adam, Gerhard; Blankenberg, Stefan; Muellerleile, Kai; Westermann, Dirk; Radunski, Ulf KonradAuthor Information
<b>Background:</b> Dysregulated inflammation is an important feature of idiopathic pulmonary arterial hypertension (IPAH) and fibrosis (IPF). However, the underlying mechanisms uncontrolled inflammatory response remain unresolved. Alarmins, namely α-defensin (Def), cathelicidin (Cath) high-mobility group box-1 (HMGB1), are crucial part immune defense system to combat against microbe invasion/tissue injury. Yet, due their potent pro-inflammatory properties, alarmins may aggravate pathology...
<b>Background:</b> Dysregulated inflammation is an important feature of idiopathic pulmonary arterial hypertension (IPAH) and fibrosis (IPF). However, the underlying mechanisms uncontrolled inflammatory response remain unresolved. Alarmins, namely α-defensin (Def), cathelicidin (Cath) high-mobility group box-1 (HMGB1), are crucial part immune defense system to combat against microbe invasion/tissue injury. Yet, due their potent pro-inflammatory properties, alarmins may aggravate pathology...
<b>Background:</b> Carbonic anhydrases (CAs) are family of enzymes that reversibly catalyze carbon dioxide hydration to bicarbonate and protons. CA9 12 overexpressed in various types tumors often associated with disease progression response therapy. Pulmonary hypertension (PH) is a severe origins has several cancer-like features. <b>Objective:</b> We hypothesize CA9/12 play an important role the pathogenesis PH subsequently may represent novel therapeutic targets future. <b>Methods:</b>...
Emotionen sind ein zentrales Element menschlichen Erlebens und spielen eine wichtige Rolle bei der Entscheidungsfindung. Diese Dissertation identifiziert drei methodische Probleme aktuellen Emotionsforschung zeigt auf, wie diese mittels computergestutzter Methoden gelost werden konnen. Dieser Ansatz wird in Forschungsprojekten demonstriert, die Entwicklung solcher sowie deren Anwendung auf konkrete Forschungsfragen beschreiben. Das erste Projekt beschreibt Paradigma welches es ermoglicht,...
Abstract Objectives: Strain is an important imaging parameter to determine myocardial deformation. This study sought 1) assess changes in left ventricular strain and ejection fraction (LVEF) from acute chronic ST-elevation infarction (STEMI) 2) analyze as a predictor of late gadolinium enhancement (LGE). Methods: 32 patients with STEMI 18 controls prospectively underwent cardiac magnetic resonance imaging. Patients were scanned 8±5 days six months after (±1.4 months). Feature tracking was...
Radunski, Ulf K.; Bohnen, Sebastian; Prüßner, Lennard; Vettorazzi, Eik; Tahir, Enver; Schneider, Jan N.; Jahnke, Charlotte; Cavus, Ersin; Adam, Gerhard; Blankenberg, Stefan; Lund, Gunnar Muellerleile, Kai Author Information