Wolfgang Lieb
A5016027312- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Health and Medical Studies
- Long-Term Effects of COVID-19
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Oral microbiology and periodontitis research
- Dermatology and Skin Diseases
- Liver Diseases and Immunity
- Asthma and respiratory diseases
- Obesity, Physical Activity, Diet
- Hormonal Regulation and Hypertension
- Epigenetics and DNA Methylation
- Inflammatory Bowel Disease
- COVID-19 and Mental Health
- Nutrition, Genetics, and Disease
- Angiogenesis and VEGF in Cancer
Kiel University
2016-2025
University Hospital Schleswig-Holstein
2016-2025
University of Lübeck
2016-2025
Ludwig-Maximilians-Universität München
2021-2024
University Medical Center
2008-2024
University Hospital and Clinics
2008-2024
LVR-Klinik Köln
2020-2023
Medizinische Hochschule Hannover
2021-2023
University of Stuttgart
2017-2021
Universitätsklinikum Würzburg
2021
Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed joint analysis two genomewide association studies coronary artery disease.
The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report genome-wide mega-analysis involving 15,212 individuals with epilepsy 29,677 controls, which reveals 16 significant loci, of 11 are novel. Using various prioritization criteria, we pinpoint the 21 most likely genes at these majority in genetic generalized epilepsies. These diverse biological functions, including coding for ion-channel subunits, transcription factors...
<h3>Context</h3>The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the hippocampus, promotes β-amyloid clearance, improves memory function animal models of aging Alzheimer disease (AD).<h3>Objective</h3>To relate baseline circulating concentrations a community-based sample individuals without dementia to incident AD during follow-up magnetic resonance imaging (MRI) measures brain survivors.<h3>Design, Setting, Participants</h3>Prospective study plasma measured...
Background— The heart progressively remodels over the life course, yet longitudinal data characterizing such remodeling in community are limited. Methods and Results— Using multilevel modeling, we analyzed up to 4 serial echocardiographic observations obtained a 16-year period 4062 Framingham Heart Study participants (mean age 45 years, 54% women; 11 485 person-observations). We related left ventricular (LV) wall thickness, LV systolic diastolic dimensions, fractional shortening age, sex,...
Abstract Aims In spite of current medical treatment approaches, mortality chronic heart failure (HF) remains high and novel modalities are thus urgently needed. A recent theory proposes a possible impact the intestinal microbiome on incidence clinical course failure. This study sought to systematically investigate, if there specific changes in patients. Methods results The 20 patients with reduced ejection fraction due ischemic or dilated cardiomyopathy was investigated by applying...
ADHD is a psychiatric disorder which characterized by hyperactivity, impulsivity and attention problems. Due to recent findings of microbial involvement in other disorders like autism depression, role the gut microbiota pathogenesis assumed but has not yet been investigated. In this study, 14 male patients (mean age: 11.9 yrs.) 17 controls 13.1 was examined via next generation sequencing 16S rDNA analyzed for diversity biomarkers. We found that (alpha diversity) significantly decreased...
Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging drug. We set out to address fundamental question of how gut microbes nutrition, key regulators host physiology, affect effects metformin. Combining two tractable genetic models, bacterium E. coli nematode C. elegans, we developed high-throughput four-way screen define underlying host-microbe-drug-nutrient interactions. show that integrate cues from metformin diet through phosphotransferase signaling...
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk kidney disease progression and cardiovascular events, but underlying mechanisms incompletely understood. Here, we conduct trans-ethnic (n = 564,257) European-ancestry specific meta-analyses genome-wide association studies UACR, including ancestry- diabetes-specific analyses, identify 68 UACR-associated loci. Genetic correlation analyses score associations in an independent electronic medical...
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...