Jonas Halfvarson
A5019960092- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Biosimilars and Bioanalytical Methods
- IL-33, ST2, and ILC Pathways
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune and Inflammatory Disorders
- Gastrointestinal motility and disorders
- Tuberculosis Research and Epidemiology
- Systemic Lupus Erythematosus Research
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Diverticular Disease and Complications
- Digestive system and related health
- Adolescent and Pediatric Healthcare
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Diagnosis and treatment of tuberculosis
- Colorectal Cancer Surgical Treatments
Örebro University
2016-2025
Örebro University Hospital
2011-2024
Karolinska Institutet
2015-2023
University Hospital of Basel
2023
Sachs' Children and Youth Hospital
2023
Stockholm South General Hospital
2023
Columbia University Irving Medical Center
2023
KU Leuven
2022
Eli Lilly (United States)
2021
OncoMed (United States)
2021
Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies identified 163 susceptibility loci for disease, mostly shared between colitis. We undertook largest genotype association study, to date, in widely used clinical subphenotypes with goal further understanding biological relations diseases.
The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution metabolites produced by gut microbiota towards status host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was discern masses thousands in fecal samples collected from 17 identical twin pairs, including healthy individuals those with CD. Pathways differentiating...
Large interindividual variation in the composition of intestinal microbiota between unrelated individuals has made it challenging to identify specific aspects dysbiosis that lead Crohn's disease (CD).To reduce variations exposure during establishment gut flora and influence genotype, we studied mucosa-associated monozygotic twin pairs were discordant (n = 6) or concordant 4) for CD. DNA was extracted from biopsies collected 5 locations ileum rectum. Bacterial 16S ribosomal RNA genes...
Objective The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. reasons for these changes remain unknown. aim this study was to investigate whether an East–West gradient the IBD Europe exists. Design A prospective, uniformly diagnosed, population based inception cohort patients 31 centres from 14 Western and eight European countries covering a total background approximately 10.1 million people created. One-third had previous experience with cohorts. Patients were...
Crohn's disease (CD) is an inflammatory bowel of complex etiology, although dysbiosis the gut microbiota has been implicated in chronic immune-mediated inflammation associated with CD. Here we combined shotgun metagenomic and metaproteomic approaches to identify potential functional signatures CD stool samples from six twin pairs that were either healthy, or had ileum (ICD) colon (CCD). Integration these omics revealed several genes, proteins, pathways primarily differentiated ICD healthy...
The Epi-IBD cohort is a prospective population-based inception of unselected patients with inflammatory bowel disease from 29 European centres covering background population almost 10 million people. aim this study was to assess the 5-year outcome and course Crohn's (CD).Patients were followed up prospectively time diagnosis, including collection their clinical data, demographics, activity, medical therapy, surgery, cancers deaths. Associations between outcomes multiple covariates analysed...
Abstract Epigenetic alterations may provide important insights into gene-environment interaction in inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation differences 240 newly-diagnosed IBD cases and 190 controls. These include 439 differentially methylated positions (DMPs) 5 regions (DMRs), which study detail using whole genome bisulphite sequencing. We replicate the top DMP ( RPS6KA2 ) DMRs VMP1, ITGB2 TXK an independent cohort. Using paired genetic epigenetic...
Abstract GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that perturbed these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and 23,650 cis -eQTL. We show determined ∼9720 modules, which ∼3000 operate in multiple tissues ∼970 on genes. modules drive association 63 200 loci, enriched multigenic...
The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) is only global organization devoted to study and management inflammatory bowel diseases (IBDs), namely, Crohn's disease ulcerative colitis. Membership composed physician-scientists who have established expertise in these diseases. hosts an annual meeting a number working groups addressing issues epidemiology IBD, diet nutrition, development use treatments IBD. There are currently 89 members IOIBD representing...
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...