A5023148106- Inflammatory Bowel Disease
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Screening and Detection
- Alcohol Consumption and Health Effects
- Eosinophilic Esophagitis
- Diet, Metabolism, and Disease
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Celiac Disease Research and Management
- Gastric Cancer Management and Outcomes
- Whipple's Disease and Interleukins
- Autoimmune and Inflammatory Disorders
- Sirtuins and Resveratrol in Medicine
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Associations and Epidemiology
- Cancer, Hypoxia, and Metabolism
- Erythrocyte Function and Pathophysiology
- IL-33, ST2, and ILC Pathways
Erasmus Hospital
2014-2025
Université Libre de Bruxelles
2010-2024
University of Liège
2011
Abstract GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that perturbed these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and 23,650 cis -eQTL. We show determined ∼9720 modules, which ∼3000 operate in multiple tissues ∼970 on genes. modules drive association 63 200 loci, enriched multigenic...
Abstract: Only 20% of patients with chronic hepatitis C (CHC) will develop cirrhosis, and fibrosis progression remains highly unpredictable. A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated steatosis that was further demonstrated to influence severity nonalcoholic fatty liver disease. The aim this assess impact polymorphism on histological damage response antiviral therapy CHC. We recruited 537...
<b><i>Background:</i></b> The preventive effect of resveratrol (RES) on the development human diseases has been verified by numerous epidemiological studies. Resveratrol triphosphate (RTP) is a stable derivative RES in which phosphate groups protect phenolic groups. <b><i>Aims:</i></b> This study compared RTP biochemical and molecular markers oxidative stress to equimolar doses (0.66 mmol) catechin-rich grape seed extract (CGSE) model metabolic...
Abstract Background The natural course of Crohn's Disease (CD) can involve the development intra-abdominal strictures and fistulae (Montreal B2 B3 phenotypes, respectively). Yet, speed disease progression to these phenotypes may differ among patients. This study retrospectively analyses a large cohort CD patients with luminal phenotype at diagnosis B1) evaluates B2/B3 in tertiary centre Belgium. Methods A total 1,262 IBD were screened from 3000+ inflammatory bowel diseases (IBD) patient’s...
Abstract Background Randomized control studies have demonstrated the efficacy of subcutaneous infliximab (IFX SC) compared to placebo. However, real-life evidence remains scarce on impact this switch effectiveness, safety, pharmacokinetics (PK), and quality life in IBD management. Methods This is a 1 year longitudinal prospective single center cohort study (EC: P2021/570) comparing 2 groups: patients remaining IFX Intravenous (IV) (IV group) switching from IV SC (SC group). The population...
Abstract Background CD patients exhibit highly variable responses to biologics. While some achieve sustained remission with only one biologic over the course of their disease, other will require sequencing multiple biologics (“difficult-to-treat” patients) for optimal disease control. The aim this study was delineate profile treatment regimen biological exposed luminal disease. Methods Among diagnosed between 1999 and 2019 B1 phenotype at diagnosis, 203 who maintained maximum follow-up (FU,...
Background & AimsUlcerative colitis (UC) is characterized by severe inflammation and destruction of the intestinal epithelium, associated with specific risk single nucleotide polymorphisms in HLA class II. Given recently discovered interactions between subsets HLA-DP molecules activating natural killer (NK) cell receptor NKp44, genetic associations UC haplotypes their functional implications were investigated.MethodsHLA-DP haplotype association analyses performed (UC: n = 13,927; control:...
Abstract Background and Aims Several factors have been reported to affect faecal calprotectin [FC] values, significant variation in FC concentrations has observed inflammatory bowel disease [IBD] patients. We aimed evaluate variability IBD patients, assess the robustness of a single stool punch. Methods This is single-centre observational case-control study. Disease activity was assessed using endoscopic clinical scores, as well C-reactive protein levels. Stool samples were collected twice...
Vedolizumab (VDZ) is effective as an induction and maintenance treatment for Crohn's disease ulcerative colitis, but, observed with antitumour necrosis factor-α (anti-TNFα) agents, some patients are nonetheless experiencing loss of response.The aim this study was to investigate the impact pharmacokinetics VDZ during on long-term response.This focused a single cohort 103 inflammatory bowel treated VDZ. trough levels (TLs) were measured by enzyme-linked immunosorbent assay (n=536 samples),...
Adalimumab (ADM) has been shown efficacious in ulcerative colitis (UC). In randomized controlled trials, dose escalation from 40 mg ADM every other week to was required 20%–25% of patients within 1 year. Real-life data suggest higher rates. Attempts for de-escalation have not studied yet. We assessed the need for, outcome of, and predictors a large retrospective cohort UC treated with ADM. included 231 consecutive 10 Belgian centers initiating treatment active before September 1, 2015...
Infliximab (IFX) is indicated for the treatment of inflammatory bowel diseases (IBD). Nevertheless, loss response (LOR) to IFX reported in up 10% 30% patients within first year treatment. Our objective was evaluate impact pharmacokinetics at induction on failure.This a longitudinal cohort study 269 with IBD treated single center. A total 2331 blood samples were prospectively collected from 2007 until March 2015 retrospective analysis clinical data. trough levels (TLs) measured by...
The genetic component of Crohn's disease (CD) is well known, with 140 susceptibility loci identified so far. In addition to single nucleotide polymorphisms typically studied in genome-wide scans, copy number variation responsible for a large proportion human variation. We performed search variants associated CD using array comparative genomic hybridization. One the found regions was validated independently through real-time PCR. Serum levels gene were measured patients and control subjects....
Abstract Background Therapeutic drug monitoring (TDM) is a diagnostic tool in the of anti-TNF therapies. Yet, benefit for TDM new biologics such as ustekinumab (USK) still controversial real-world experiences. Methods This monocentric retrospective study aims to correlate USK trough levels (TLs) with clinical and endoscopic data. All patients have given written consent Biobank (B2011/005). Endoscopic disease was defined quiescent absence lesions, mild presence few superficial ulcerations,...