A5057380612- Systemic Sclerosis and Related Diseases
- Synthesis and biological activity
- Bioactive natural compounds
- Synthesis and Catalytic Reactions
- Glycosylation and Glycoproteins Research
- Dermatologic Treatments and Research
- Acute Myeloid Leukemia Research
- Aldose Reductase and Taurine
- Synthesis of β-Lactam Compounds
- Autoimmune Bullous Skin Diseases
- Axial and Atropisomeric Chirality Synthesis
- Simulation-Based Education in Healthcare
- Receptor Mechanisms and Signaling
- Glutathione Transferases and Polymorphisms
- Cardiac, Anesthesia and Surgical Outcomes
- Molecular spectroscopy and chirality
- Neonatal Health and Biochemistry
- Inflammatory Myopathies and Dermatomyositis
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Pain Management
- Cell Adhesion Molecules Research
- Quinazolinone synthesis and applications
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Polymer Nanocomposites and Properties
Tokyo University of Science
2023-2024
Breast Center
2024
University of Hawaiʻi at Mānoa
2020-2024
Himeji Red Cross Hospital
2021-2024
Hoshi University
2022
Ebara (Japan)
2022
Kumamoto University
1997-2021
National Institute for Physiological Sciences
2018-2019
RIKEN
2019
The Graduate University for Advanced Studies, SOKENDAI
2018
Abstract Germline removal provokes longevity in several species and shifts resources towards survival repair. Several Caenorhabditis elegans transcription factors regulate arising from germline removal; yet, how they work together is unknown. Here we identify a Myc-like HLH factor network comprised of Mondo/Max-like complex (MML-1/MXL-2) to be required for induced by removal, as well reduced TOR, insulin/IGF signalling mitochondrial function. increases MML-1 nuclear accumulation activity....
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a major endothelial receptor for lipoprotein, and assumed to play proatherogenic role in atherosclerosis. LOX-1 expression induced by inflammatory cytokines as well stimuli. protein binds aged/apoptotic cells, activated platelets, bacteria, suggesting that it may have diverse activities vivo . Here, we reveal endotoxin-induced inflammation. In model of endotoxemia, injection high dose endotoxin into rats leukopenia within 1 h...
Long non-coding RNAs (lncRNAs) are thought to have various functions other than RNA silencing. We tried evaluate the expression of lncRNAs in patients with systemic sclerosis (SSc) and determined whether controls collagen dermal fibroblasts. lncRNA was by real-time PCR situ hybridization. Protein mRNA levels were analysed using immunoblotting PCR. found TSIX, one lncRNAs, overexpressed SSc fibroblasts both vivo vitro, which inhibited transfection transforming growth factor (TGF)-β1 siRNA....
The overexpression of IL-12 family cytokines is implicated in the pathogenesis SSc, but their exact role still unclear. aim this study was to investigate regulation extracellular matrix expression by IL-23 and its contribution phenotype SSc.The mRNA determined PCR array real-time PCR. levels proteins were immunoblotting immunohistochemical staining. effect on dermal fibrosis vivo examined a mouse model SSc induced bleomycin injection.Among members, decreased type I collagen protein cultured...
We optimized our previously reported proline-based STAT3 inhibitors into an exciting new series of (R)-azetidine-2-carboxamide analogues that have sub-micromolar potencies. 5a, 5o, and 8i STAT3-inhibitory potencies (IC50) 0.55, 0.38, 0.34 μM, respectively, compared to greater than 18 μM against STAT1 or STAT5 activity. Further modifications derived analogues, including 7e, 7f, 7g, 9k, addressed cell membrane permeability other physicochemical issues. Isothermal titration calorimetry analysis...
Signal transducer and activator of transcription (Stat)3 is a valid anticancer therapeutic target. We have discovered highly potent chemotype that amplifies the Stat3-inhibitory activity lead compounds to levels previously unseen. The azetidine-based compounds, including H172 (9f) H182, irreversibly bind Stat3 selectively inhibit (IC
In recent years, synthetic opioids have emerged as a predominant cause of drug-overdose-related fatalities, causing the "opioid crisis." To design safer therapeutic agents, we accidentally discovered μ-opioid receptor (MOR) antagonists based on fentanyl with relatively uncomplicated chemical composition that potentiates structural modifications. Here, showed development novel atropisomeric analogues exhibit more potent antagonistic activity against MOR than naloxone, morphinan antagonist....
C9-methylated quazepam 1 was prepared, and its physicochemical properties were investigated. The atropisomers of isolated as (a
Abstract The total syntheses of (−)‐rotenone and (−)‐dalpanol have been achieved by a group‐selective, stereospecific 1,2‐shift an epoxy alcohol S N Ar cyclizations. Three oxacycles are constructed, thus illustrating versatile synthetic route to various rotenoids.
We present here a 63-year-old man with chronic hepatitis C who developed bullous lesions and anti-intercellular antibodies when he received interferon (IFN) α-2a, 9 MU subcutaneously, 3 times week for months. The direct immunofluorescence was consistent pemphigus features. indirect showed negative before IFN treatment, but it became positive after immunoblot study no specific bands. This is the third report of following therapy.
Abstract Immune checkpoint inhibitors have increased the median survival of melanoma patients. To improve their effects, antigen‐specific therapies utilizing melanoma‐associated antigens should be developed. Cell division cycle‐associated protein 1 ( CDCA 1), which has a specific function at kinetochores for stabilizing microtubule attachment, is overexpressed in various cancers. 1, member cancer–testis antigens, does not show detectable expression levels normal tissues. Quantitative reverse...
The neuronal K+–Cl− cotransporter KCC2 maintains a low intracellular Cl− concentration and facilitates hyperpolarizing GABAA receptor responses. also plays separate role in stabilizing enhancing dendritic spines the developing nervous system. Using conditional transgenic mouse strategy, we examined whether overexpression of enhances adult system characterized effects on spine dynamics motor cortex vivo during rotarod training. Mice overexpressing showed significantly increased density apical...
An approach to 2-substituted isoflavonoids is reported based on the 1,2-shift of aryl group in catechin skeleton followed by situ alkylation. Synthesis (-)-equol, a natural isoflavan with estrogenic activities, was achieved.
Taku Noumi, Shoka Kimura, Takuro Fushimi, Shuichi Sakamoto, Kayo Nakamura, Soichiro Toshiaki Ohara, Shuko Mashimo, Hiroyuki Tao, Takanori Watanabe, Daizo Kishino