A5016477818- Inflammatory Bowel Disease
- Microscopic Colitis
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Medical Device Sterilization and Disinfection
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Infection Control in Healthcare
- Healthcare cost, quality, practices
- Bacterial biofilms and quorum sensing
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Urinary Tract Infections Management
- Mycobacterium research and diagnosis
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Gut microbiota and health
- Eosinophilic Esophagitis
- Central Venous Catheters and Hemodialysis
- Autoimmune and Inflammatory Disorders
- Surgical site infection prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Clostridium difficile and Clostridium perfringens research
- Infection Control and Ventilation
- Dialysis and Renal Disease Management
Erasmus MC
2016-2025
Erasmus University Rotterdam
2014-2025
Ghent University Hospital
2016-2025
University Medical Center Groningen
2025
University of Groningen
2025
Elisabeth-TweeSteden Ziekenhuis
2012-2024
Vrije Universiteit Brussel
2013-2024
Freie Universität Berlin
2024
European Society of Clinical Microbiology and Infectious Diseases
2019-2023
Leibniz Institute of Virology (LIV)
2023
Nasal carriers of Staphylococcus aureus are at increased risk for health care-associated infections with this organism. Decolonization nasal and extranasal sites on hospital admission may reduce risk.In a randomized, double-blind, placebo-controlled, multicenter trial, we assessed whether rapid identification S. by means real-time polymerase-chain-reaction (PCR) assay, followed treatment mupirocin ointment chlorhexidine soap, reduces the hospital-associated infection.From October 2005...
To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547 patients and 928 controls. We found three chromosome regions that provided evidence of p-values between 10(-6) 10(-9). Two these (IL23R on Chromosome 1 CARD15 16) correspond to genes previously reported be associated CD. In addition, 250-kb region 5p13.1 was contain multiple markers strongly suggestive (including four p < 10(-7))....
Vacuum‐assisted closure has become a new technique in the challenging management of contaminated, acute, and chronic wounds. Although promising clinical results have been described, scientific proof to substantiate mechanism action this therapy is scarce. In present study, we examined whether positive effect on wound healing found vacuum‐assisted closure–treated wounds could be explained by an bacterial load. Fifty‐four patients who needed open before surgical were included study. Wounds...
Abstract The management of the dysbiosed gut microbiota in inflammatory bowel diseases (IBD) is gaining more attention as a novel target to control this disease. Probiotic treatment with butyrate-producing bacteria has therapeutic potential since these are depleted IBD patients and butyrate beneficial effects on epithelial barrier function overall health. However, studies assessing effect probiotic supplementation microbe-microbe host-microbe interactions rare. In study, (three mono-species...
We identified 10 patients with disseminated Mycobacterium chimaera infections subsequent to open-heart surgery at three European Hospitals. Infections originated from the heater–cooler unit of heart–lung machine. Here we describe clinical aspects and treatment course this novel entity. Interdisciplinary care follow-up all was documented by study team. Patients' characteristics, manifestations, microbiological findings, therapeutic measures including surgical reinterventions were reviewed...
Inflammatory bowel diseases (IBD) are complex multifactorial characterized by an inappropriate host response to altered commensal microbiome and dysfunctional mucus barrier. Cigarette smoking is the best known environmental risk factor in IBD. Here, we studied influence of chronic smoke exposure on gut microbiome, layer composition immune factors conventional mice. We compared smoke-exposed with air-exposed mice (n = 12) after a 24 weeks. Both Illumina sequencing 6) denaturing gradient gel...
Duodenoscope contamination remains a persistent problem, exposing patients to infection risks. Automation in reprocessing may limit human error, reduce workload, and increase uniformity traceability. However, its effectiveness should be evaluated before implementation. This study assessed the impact of implementing novel water-based automated endoscope cleaning process on duodenoscope contamination. before-and-after intervention compared methods. From January 2022 December 2023, conventional...
Abstract Infections due to multidrug-resistant organisms (MDROs) are a health threat increasing patient morbidity and mortality the burden on healthcare systems. Robust infection prevention control (IPC) measures needed minimize their emergence in hospitals. Therefore, various international national IPC guidelines exist, yet lack of harmonized complicates management patients seeking across European borders. This study explores similarities differences for vancomycin-resistant enterococci...
Objective. To study potential determinants of hand hygiene compliance among healthcare workers in the hospital setting. Design. A qualitative based on structured-interview guidelines, consisting 9 focus group interviews involving 58 persons and 7 individual interviews. Interview transcripts were subjected to content analysis. Setting. Intensive care units surgical departments 5 hospitals varying size Netherlands. Participants. total 65 nurses, attending physicians, medical residents,...