A5023167642- Surgical site infection prevention
- Antibiotic Use and Resistance
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Urinary Tract Infections Management
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Infections and Treatments
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- COVID-19 and healthcare impacts
- Clinical practice guidelines implementation
- Health, Medicine and Society
- Bacterial Identification and Susceptibility Testing
- Healthcare cost, quality, practices
- Pneumocystis jirovecii pneumonia detection and treatment
- Healthcare Systems and Practices
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Patient Satisfaction in Healthcare
- COVID-19 epidemiological studies
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- Viral Infections and Outbreaks Research
- Colorectal Cancer Surgical Treatments
- Total Knee Arthroplasty Outcomes
Hôpital du Valais
2015-2024
University Hospital of Bern
2023
University of Bern
2001-2023
University of Geneva
2022
Robert Koch Institute
2022
University of St. Gallen
2022
University of Lausanne
2010-2022
Spital Thurgau (Switzerland)
2022
Museum of Heilongjiang Province
2021
Hôpital de Sion
2019
ABSTRACT Pseudomonas aeruginosa is a leading cause of nosocomial infections. The risk emergence antibiotic resistance may vary with different treatments. To compare the risks associated four antipseudomonal agents, ciprofloxacin, ceftazidime, imipenem, and piperacillin, we conducted cohort study, assessing relative for resistant P. in patients treated any these drugs. A total 271 (followed 3,810 days) infections due to were study agents. Resistance emerged 28 (10.2%). Adjusted hazard ratios...
With the ongoing COVID-19 pandemic, it is crucial to assess current burden of disease community-acquired SARS-CoV-2 Omicron variant in hospitalized patients tailor appropriate public health policies. Comparisons with better-known seasonal influenza infections may facilitate such decisions.To compare in-hospital outcomes influenza.This cohort study was based on a national and registry. Hospitalized aged 18 years older infection who were admitted between January 15 March 15, 2022 (when...
Antimicrobial resistance is an increasing problem.To examine the clinical and economic impact of antibiotic in Pseudomonas aeruginosa.In-hospital mortality, secondary bacteremia, length stay, hospital charges were examined a cohort 489 inpatients with positive cultures for P aeruginosa. One hundred forty-four had resistant baseline aeruginosa isolate 30 emerge during follow-up. Multivariable survival analytic methods used to adjust confounding effects time.The overall in-hospital mortality...
In Brief Objective: To compare surgical site infection (SSI) rates in open or laparoscopic appendectomy, cholecystectomy, and colon surgery. investigate the effect of laparoscopy on SSI these interventions. Background: Lower have been reported among various advantages associated with when compared surgery, particularly cholecystectomy. However, biases such as lack postdischarge follow-up confounding factors might contributed to observed differences between 2 techniques. Methods: This...
Potential risk factors for the detection of imipenem-resistant Pseudomonas aeruginosa in hospitalized patients were assessed by a case-control study. Forty whose first P. isolate was resistant or intermediate to imipenem more likely than 387 controls have received (odds ratio [OR] = 16.9; P < .0001) and undergone organ transplantation (OR 3.9; .008). No significant difference found treatments with other antibiotics, underlying diseases, demographic characteristics, different exposures...
ABSTRACT Nosocomial pneumonia and acute peritonitis may be caused by a wide array of pathogens, combination therapy is often recommended. We have previously shown that imipenem-cilastatin monotherapy was as efficacious the plus netilmicin in these two settings. The efficacy now compared to piperacillin-tazobactam patients with nosocomial or peritonitis. Three hundred seventy one were randomly assigned receive either (0.5 g four times day) (4.5 three day). thirteen assessable (154 159...
OBJECTIVES:To measure the prevalence of, and to establish predictors for, nasal carriage of methicillinresistant Staphylococcus aureus (MRSA) at hospital admission.To evaluate mannitol-salt agar with oxacillin for simultaneous detection identification MRSA from swabs.DESIGN: Three-month prospective case-control survey, data collected interviews computerized databases.The criterion standard was culture on Mueller-Hinton 6 µg/mL (National Committee Clinical Laboratory Standards...
Abstract Background There is no dedicated scoring system for predicting the risk of surgical-site infection (SSI) after resection colon or rectum. Generic scores, such as National Nosocomial Infections Surveillance index, are not used by colorectal surgeons. Methods Multivariable analysis factors SSI was performed in patients who underwent rectum, and were followed during first month operation. A logistic regression model to identify determinant variables construct a predictive score....
OBJECTIVES To report on the results of Swiss national surgical site infection (SSI) surveillance program, including temporal trends, and to describe methodological characteristics that may influence SSI rates DESIGN Countrywide survey over a 4-year period. Analysis prospectively collected data patient procedure as well aggregated stratified by risk categories, type SSI, time diagnosis. Temporal trends were analyzed using stepwise multivariate logistic regression models with adjustment effect...
BACKGROUND SARS-CoV-2/COVID-19, which emerged in China late 2019, rapidly spread across the world with several million victims 213 countries. Switzerland was severely hit by virus, 43,000 confirmed cases as of 1 September 2020. AIM In cooperation Federal Office Public Health, we set up a surveillance database February 2020 to monitor hospitalised patients COVID-19, addition their mandatory reporting system. METHODS Patients for more than 24 hours positive polymerase chain-reaction test, from...
The Panton-Valentine leukocidin is associated with staphylococcal skin and pulmonary infections. We describe a school outbreak of infections the public health response to it. Nasal carriage leukocidin-positive Staphylococcus aureus clone was detected only in previously ill classmates their family members.
The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) at an international level shows that most MRSA strains belong to a few pandemic clones. At the local level, predominance one or two clones was generally reported. However, situation is evolving and new are emerging worldwide, some them with specific biological characteristics, such as presence Panton-Valentine leucocidin (PVL). Understanding these changes levels great importance. Our objective analyze evolution multiple...
In Brief a nationwide prevalence study, 10.6% of patients with recent surgery suffered from healthcare-associated infections compared to 4.2% without surgery. Most (48%) were surgical site infections. Patients undergoing carried less intrinsic, but more extrinsic, potentially modifiable risk factors.
The increasing incidence of candidemia and emergence drug-resistant Candida species are major concerns worldwide. Long-term surveillance studies needed.The Fungal Infection Network Switzerland (FUNGINOS) conducted a 15-year (2004-2018), nationwide, epidemiological study candidemia. Hospital-based candidemia, distribution, antifungal susceptibility, consumption were stratified in 3 periods (2004-2008, 2009-2013, 2014-2018). Population-based over the period 2009-2018 derived from Swiss...
Objective Although surgical-site infection (SSI) rates are advocated as a major evaluation criterion, the reproducibility of SSI diagnosis is unknown. We assessed agreement in diagnosing among specialists involved surveillance Europe. Methods Twelve case-vignettes based on suspected were submitted to 100 infection-control physicians (ICPs) and 86 surgeons 10 European countries. Each participant scored eight randomly-assigned secure online relational database. The intra-class correlation...
BACKGROUND As clinical signs of COVID-19 differ widely among individuals, from mild to severe, the definition risk groups has important consequences for recommendations public, control measures and patient management, needs be reviewed regularly. AIM The aim this study was explore factors in-hospital mortality intensive care unit (ICU) admission hospitalised patients during first epidemic wave in Switzerland, as an example a country that coped well pandemic. METHODS This included all (n =...
Importance World Health Organization guidelines recommend administering surgical antimicrobial prophylaxis (SAP), including cefuroxime, within 120 minutes prior to incision. However, data from clinical settings supporting this long interval is limited. Objective To assess whether earlier vs later timing of administration cefuroxime SAP associated with the occurrence site infections (SSI). Design, Setting, and Participants This cohort study included adult patients who underwent 1 11 major...
Background Since the onset of COVID-19 pandemic, disease has frequently been compared with seasonal influenza, but this comparison is based on little empirical data. Aim This study compares in-hospital outcomes for patients community-acquired and influenza in Switzerland. Methods retrospective multi-centre cohort includes > 18 years admitted or A/B infection determined by RT-PCR. Primary secondary were mortality intensive care unit (ICU) admission influenza. We used Cox regression...