A5055337379- Antifungal resistance and susceptibility
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Orthopedic Infections and Treatments
- Fungal Infections and Studies
- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Infection Control in Healthcare
- Surgical site infection prevention
- Orthopaedic implants and arthroplasty
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- Infective Endocarditis Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Clostridium difficile and Clostridium perfringens research
- Burn Injury Management and Outcomes
- Medical Device Sterilization and Disinfection
- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Infection Control and Ventilation
- Nail Diseases and Treatments
- Healthcare cost, quality, practices
- Total Knee Arthroplasty Outcomes
Medical University of Vienna
2015-2024
Vienna General Hospital
2001-2023
European Society of Clinical Microbiology and Infectious Diseases
2019-2023
University of Vienna
1996-2019
Pfizer (Austria)
2018
Takeda (Austria)
2018
Clinical Orthopaedics and Related Research
2018
Universitätszahnklinik Wien
1992-2018
Barmherzige Schwestern Krankenhaus Wien
1998-2013
Office of Infectious Diseases
2009-2010
Abstract. Because development of acute renal failure is one the most potent predictors outcome in cardiac surgery patients, prevention dysfunction utmost importance perioperative care. In a double-blind randomized controlled trial, effectiveness dopamine or furosemide impairment after was evaluated. A total 126 patients with preoperatively normal function undergoing elective received continuous infusion either “renal-dose” (2 μg/kg per min) (group D), (0.5 F), isotonic sodium chloride as...
Background: Invasive fungal infections are often diagnosed by histopathology without identification of the causative fungi, which show significantly different antifungal susceptibilities. Aims: To establish and evaluate a system two seminested polymerase chain reaction (PCR) assays to identify discriminate between agents aspergillosis mucormycosis in paraffin wax embedded tissue samples. Methods: DNA 52 blinded samples from five centres was extracted used as template PCR targeting...
With the advent of new antifungal agents, identification a causative pathogen is crucial to guide treatment invasive mold infection. However, tissue cultures often fail grow fungal in cases suspected infection.In prospective multicenter study, we compared results histopathological analysis, culture, and 2 seminested polymerase chain reaction assays identifying Aspergillus species Zygomycetes as agents infections using respiratory tract biopsy samples obtained from 56 immunocompromised...
Abstract The purpose of this study was to improve the pathogen detection in prosthetic joint infections, particularly evaluate feasibility sonication culture method clinical routine. Explanted components all patients with presumptive or implant infection were sonicated separately sterile containers dislodge adherent bacteria from surfaces and cultured. results compared conventional tissue culture. We investigated 60 consecutive loosening prostheses implants Forty had septic 20 aseptic (24...
ObjectivesTo test the effects of several biocides [N-propanol, a commercially available propanol/ethanol/chlorhexidine mixture, polyvinylpyrolidone (povidone-iodine) and hydrogen peroxide] on established biofilms Staphylococcus epidermidis isolated from patients with cardiac implant infections catheter-related bacteraemia.
ObjectivesThe aim of the present study was to evaluate in vitro activity and synergism combinations amphotericin B/caspofungin B/posaconazole against Candida albicans, grown either as planktonic cells or biofilms.
Allogeneic hematopoietic stem cell transplant (HSCT) recipients experience an increased risk for invasive fungal diseases (IFDs).This retrospective cohort study at the Medical University of Vienna aspired to assess incidence, characteristics and outcome IFDs as well associated factors in a setting where only 43 % patients were given systemic antifungal prophylaxis during aplasia. classified probable or proven according EORTC/MSG consensus group. All adult (n = 242) receiving allogeneic HSCT...
Abstract Background Carbapenemase-producing enterobacteriaceae (CPE) are a major threat for severely ill patients. However, only limited data on the epidemiology and evidence-based infection prevention control measures available. The aim of this study was to investigate patients with CPE, characterizing CPE isolates by their resistance mechanisms genetic similarity, explore risk factors acquisition, evaluate effectiveness current measures. Methods A retrospective case-control performed using...
Healthcare-associated infections (HAI) are among the most common adverse events of medical care. Surveillance HAI is a key component successful infection prevention programmes. Conventional surveillance - manual chart review resource intensive and limited by concerns regarding interrater reliability. This has led to development use automated (AS). Many AS systems product in-house efforts heterogeneous in their design methods. With this roadmap, PRAISE network aims provide guidance on how...
In 35 patients fulfilling the criteria of systemic inflammatory response syndrome (SIRS) infectious origin, tumor necrosis factor- α (TNF- ), interleukin-6 (IL-6), factor-soluble receptor (TNF-sR), and interleukin-12 (IL-12), C-reactive protein (CRP) levels Acute Physiology, And Chronic Health Evaluation III score (APACHE III) were determined on days 1 to 7, 14, 21, 28. The Mortality Probability Models (MPM) II sepsis was assessed at time admission into study. MPM correlated with IL-6 plasma...
Summary Multidrug resistance may pose a serious problem to antifungal therapy. The Candida albicans Cdr2p is one of two A TP‐ b inding c assette (ABC) transporters mediating in vivo through increased drug efflux. Echinocandins such as caspofungin represent the newest class antifungals that target cell wall synthesis. We show here by agar plate assays cross‐resistant clinical isolates C. display high minimal inhibitory concentrations (MICs) when compared with sensitive ATCC reference strain....
Abstract Objective . Defective regulation of programmed cell death (apoptosis) may play a role in the development autoimmune diseases, and proto‐oncogene bcl ‐2 is involved control apoptosis immunocompetent cells. We therefore wished to investigate expression peripheral lymphocytes patients with systemic lupus erythematosus (SLE), prototypical disease. Methods Levels SLE and, for comparison, healthy controls rheumatoid arthritis (RA), bacterial infections, chronic B lymphocytic leukemia were...
The aim of this study was to evaluate whether coating titanium discs with selenium in the form sodium selenite decreased bacterial adhesion Staphylococcus aureus and Staph. epidermidis impeded osteoblastic cell growth. In order adhesion, sterile were coated increasing concentrations incubated solutions (ATCC 29213) (DSM 3269) stained Safranin-O. effect on growth also observed. adherence MG-63 cells detected by staining proportion covered area calculated imaging software. tested strain showed...
Environmental surface decontamination is a crucial tool to prevent the spread of infections in hospitals. However, manual cleaning and disinfection may be insufficient eliminate pathogens from contaminated surfaces. Ultraviolet-C (UV-C) irradiation deploying autonomous devices, i.e. robots, are increasingly advertised complement standard procedures with concurrent reduction time workload. Although principle UV-C based proven, little known about operational details delivered by robots. To...
Abstract Surgical site infection (SSI) following osteosynthesis of trochanteric or subtrochanteric fractures is a rare but serious complication with incidence rate ranging from 1 to 3%. SSIs are associated higher mortality and increased length hospital stay resulting in healthcare costs loss life quality. In this retrospective analysis all patients SSI at the Department Trauma Surgery were identified. We included surgical procedures performed 1992 2018, using data electronic health records...
The pathophysiologic backgrounds of anemia in malaria are complex and multifactorial. purpose the present study was to measure serum concentrations erythropoietin (EPO) evaluate adequacy EPO production patients suffering from acute Plasmodium falciparum malaria. Fifteen with complicated were included study. Serum samples taken on day admission, days 7, 14, 21, 28. measured using an enzyme-linked immunosorbent assay. median concentration 15.6 mU/ml admission (range 0.5–567) mU/ml, 10.6...