A5074534140- Complement system in diseases
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Biosensors and Analytical Detection
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Antibiotic Resistance in Bacteria
- Renal Diseases and Glomerulopathies
- Nosocomial Infections in ICU
- Cytomegalovirus and herpesvirus research
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Infective Endocarditis Diagnosis and Management
- Drug-Induced Adverse Reactions
- Systemic Lupus Erythematosus Research
- Fungal Infections and Studies
- Patient Satisfaction in Healthcare
- Urinary Tract Infections Management
- Bacterial Infections and Vaccines
University Hospital of Basel
2016-2025
University of Basel
2013-2024
Kantonsspital Winterthur
2023-2024
Hospital Base
2022-2023
Faculty (United Kingdom)
2023
Kantonsspital Aarau
2022
Kantonsspital Baselland
2022
International Society for Infectious Diseases
2016
Swiss National Science Foundation
2016
The University of Melbourne
2013-2015
ABSTRACT Ceftazidime-avibactam (CAZ-AVI) is a recently approved β-lactam–β-lactamase inhibitor combination with the potential to treat serious infections caused by carbapenem-resistant organisms. Few patients such were included in CAZ-AVI clinical trials, and experience lacking. We present case series of Enterobacteriaceae (CRE) or Pseudomonas aeruginosa (CRPa) who treated salvage therapy on compassionate-use basis. Physicians had prescribed completed report form. used descriptive statistics...
Extended-spectrum beta-lactamase-expressing Gram-negative bacilli (ESBL-GNB) now commonly cause community-acquired infections, including urinary tract infections (UTI), and represent a challenge for practitioners in choosing empirical antibiotics. The aim of this study was to describe the epidemiology clinical characteristics UTIs/bacteriuria due ESBL-GNB Australia.At single-site tertiary referral hospital, 100 cases with were matched where caused by organisms matching ESBL bacterial species...
Abstract Objectives SARS-CoV-2 may cause acute lung injury, and secondary infections are thus relevant complications in patients with COVID-19 pneumonia. However, detailed information on community- hospital-acquired among pneumonia is scarce. Methods We identified 220 SARS-CoV-2-positive hospitalized at the University Hospital Basel, Switzerland (between 25 February 31 May 2020). excluded who declined general consent ( n = 12), without clinical evidence of 29), for < 24 h 17). evaluated...
A dysregulated immune response with hyperinflammation is observed in patients severe coronavirus disease 2019 (COVID-19). The aim of the present study was to assess safety and potential benefits human recombinant C1 esterase inhibitor (conestat alfa), a complement, contact activation kallikrein-kinin system regulator, COVID-19. Patients evidence progressive after 24 h including an oxygen saturation <93% at rest ambient air were included University Hospital Basel, Switzerland April 2020....
Early detection, standardized therapy, adequate infrastructure and strategies for quality improvement should constitute essential components of every hospital's sepsis plan. To investigate the extent to which recommendations from guidelines are implemented availability care patients with in acute hospitals. A multidisciplinary cross-sectional questionnaire was used This included use definitions, implementation guideline recommendations, diagnostic therapeutic infrastructure, antibiotic...
Background The Mannose-binding lectin (MBL) pathway of complement plays a pivotal role in the pathogenesis ischemia/reperfusion (I/R) injury after experimental ischemic stroke. As comparable data human stroke are limited, we investigated more detail association MBL deficiency with infarction volume and functional outcome large cohort patients receiving intravenous thrombolysis or conservative treatment. Methodology/Principal Findings In post hoc analysis prospective study, admission...
Coronavirus disease 2019 (COVID-19) leads to inflammatory cytokine release, which can downregulate the expression of metabolizing enzymes. This cascade affects drug concentrations in plasma. We investigated association between lopinavir (LPV) and hydroxychloroquine (HCQ) plasma levels acute-phase inflammation marker C-reactive protein (CRP). LPV 92 patients hospitalized at our institution were prospectively collected. Lopinavir-ritonavir was administered every 12 hours, 800/200 mg on day 1...
The first case of SARS-CoV-2 in Basel, Switzerland was detected on February 26 th 2020. We present a phylogenetic study to explore viral introduction and evolution during the exponential early phase local COVID-19 outbreak from until March 23 rd . sequenced naso-oropharyngeal swabs 746 positive tests that were performed at University Hospital Basel period. successfully generated 468 high quality genomes unique patients called variants with our Pipeline (COVGAP), analysed genetic diversity...
The Biofire
Abstract Autoantibodies against complement C1q (anti-C1q) are frequently found in patients with systemic lupus erythematosus (SLE). They strongly correlate the occurrence of severe nephritis, suggesting a pathogenic role SLE. Because anti-C1q known to recognize neoepitope on bound C1q, but not fluid-phase aim this study was clarify origin by determining mechanism that renders antigenic. We investigated from serum and purified total IgG SLE hypocomplementemic urticarial vasculitis as well two...
The increasing incidence of candidemia and emergence drug-resistant Candida species are major concerns worldwide. Long-term surveillance studies needed.The Fungal Infection Network Switzerland (FUNGINOS) conducted a 15-year (2004-2018), nationwide, epidemiological study candidemia. Hospital-based candidemia, distribution, antifungal susceptibility, consumption were stratified in 3 periods (2004-2008, 2009-2013, 2014-2018). Population-based over the period 2009-2018 derived from Swiss...
A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has targeted numerous inhibitors, e.g., remdesivir, only provisionally approved treatment to-date, although clinical impact these interventions remains inconclusive. However, potential emergence resistance poses a threat to efficacy any successful therapies on wide scale. Here, we propose framework...
Autoantibodies against C1q strongly correlate with the occurrence of severe nephritis in patients systemic lupus erythematosus (SLE). We undertook this study to determine whether identification epitope(s) recognized by these autoantibodies might lead a better diagnostic assay and help elucidate putative role anti-C1q SLE.SLE patient-derived Fab were used microarray-based peptide scan identify sequence anti-C1q. Anti-C1q binding target was further analyzed using real-time interaction...
Cytomegalovirus (CMV) retinitis is a major cause of visual impairment and blindness among patients with uncontrolled HIV infections. Whereas polymorphisms in interferon-lambda 3 (IFNL3, previously named IL28B) strongly influence the clinical course hepatitis C, few studies examined role such infections due to viruses other than C virus.To analyze association newly identified IFNL3/4 variant rs368234815 susceptibility CMV-associated cohort HIV-infected patients.This retrospective longitudinal...
We report an imported case of louse-borne relapsing fever in a young adult Eritrean refugee who presented with shortly after arriving Switzerland. Analysis blood smears revealed spirochetes identified as Borrelia recurrentis by 16S rRNA gene sequencing. believe that may be seen more frequently Europe consequence recent increase refugees from East Africa travelling to under poor hygienic conditions confined spaces.
Abstract Objectives Detecting severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is key to the clinical and epidemiological assessment of CoVID‐19. We cross‐validated manual automated high‐throughput testing for SARS‐CoV‐2‐RNA, evaluated SARS‐CoV‐2 loads in nasopharyngeal–oropharyngeal swabs (NOPS), lower fluids, plasma, analyzed detection rates after lockdown relaxation measures. Methods Basel‐S‐gene, Roche‐E‐gene, Roche‐cobas®6800‐Target1 Target2 were prospectively validated 1344...