A5102996393- Antifungal resistance and susceptibility
- Oral health in cancer treatment
- Biomarkers in Disease Mechanisms
- Cytomegalovirus and herpesvirus research
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Oral microbiology and periodontitis research
- Ocular Diseases and Behçet’s Syndrome
- Immunodeficiency and Autoimmune Disorders
- Neutropenia and Cancer Infections
- Renal and related cancers
- Oral Health Pathology and Treatment
- Psoriasis: Treatment and Pathogenesis
- Pneumonia and Respiratory Infections
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Complement system in diseases
- Polyomavirus and related diseases
- Nail Diseases and Treatments
- Fetal and Pediatric Neurological Disorders
- Breast Lesions and Carcinomas
- Organ and Tissue Transplantation Research
- Legionella and Acanthamoeba research
- Histiocytic Disorders and Treatments
- Hepatitis B Virus Studies
University of Lausanne
2014-2023
Office of Infectious Diseases
2014-2019
Medical University of Lublin
2017-2019
University of Zurich
2019
University Hospital of Lausanne
2014-2016
Jagiellonian University
2016
Columbia College
2015
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2010
Górnośląskie Centrum Medyczne
1998
Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that are independent factors for mold infections 1101 solid organ recipients, thereby strengthening their role in infection pathogenesis and patients' stratification.
Polymorphisms in IFNL3 and IFNL4, the genes encoding interferon λ3 λ4, respectively, have been associated with reduced hepatitis C virus clearance. We explored role of such polymorphisms on incidence cytomegalovirus (CMV) infection solid-organ transplant recipients.White patients participating Swiss Transplant Cohort Study 2008-2011 were included. A novel functional TT/-G polymorphism (rs368234815) CpG region upstream was investigated.A total 840 recipients at risk for CMV included, among...
Background. Single-nucleotide polymorphisms (SNPs) in immune genes have been associated with susceptibility to invasive mold infection (IMI) among hematopoietic stem cell but not solid-organ transplant (SOT) recipients.
Cytomegalovirus (CMV) retinitis is a major cause of visual impairment and blindness among patients with uncontrolled HIV infections. Whereas polymorphisms in interferon-lambda 3 (IFNL3, previously named IL28B) strongly influence the clinical course hepatitis C, few studies examined role such infections due to viruses other than C virus.To analyze association newly identified IFNL3/4 variant rs368234815 susceptibility CMV-associated cohort HIV-infected patients.This retrospective longitudinal...
UL18 is a human CMV (HCMV) MHC class I (MHCI) homolog that efficiently inhibits leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1)+ NK cells. We found an association of LILRB1 polymorphisms in the regulatory regions and ligand-binding domains with control HCMV transplant patients. Naturally occurring variants expressed model cells showed functional differences classical MHCI, but not HLA-G. The altered recognition was recapitulated binding assays LILRB1. Each 4...
Objectives: To evaluate the influence of genetic polymorphisms on susceptibility to Candida colonization and intra-abdominal candidiasis, a blood culture–negative life-threatening infection in high-risk surgical ICU patients. Design: Prospective observational cohort study. Setting: Surgical ICUs from two University hospitals Fungal Infection Network Switzerland. Patients: Eighty-nine patients at high risk for candidiasis (68 with recurrent gastrointestinal perforation 21 acute necrotizing...
We here report the case of a woman with dermatophytosis thighs due to Trichophyton mentagrophytes where an unusual clinical picture posed considerable diagnostic and therapeutic problems. She presented numerous skin lesions located on dorsolateral face left thigh medial surface right calf. The initial consisted small itchy pustules that evolved exfoliation after scratching. Results histopathologic examination biopsy were consistent dermatophytosis, although negativity PAS staining did not...
Pneumocystis jirovecii pneumonia (PJP) is an important cause of morbidity and mortality in HIV-positive patients. Polymorphisms immune genes are increasingly reported to influence susceptibility fungal infections. We analysed the role 21 single nucleotide polymorphisms from 19 candidate on PJP development patients Swiss HIV Cohort Study.
Background: Kaposi's sarcoma, the most common AIDS-related cancer, represents a major public concern in resource-limited countries. Single nucleotide polymorphisms within Interferon lambda 3/4 region (IFNL3/4) determine expression, function of IFNL4, and influence clinical course an increasing number viral infections. Objectives: To analyze whether IFNL3/4 variants are associated with susceptibility to sarcoma among MSM enrolled Swiss HIV Cohort Study (SHCS). Methods: The risk developing...
We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and prospective matched-control study. found that an SNP located interleukin-1B at rs1143627 was significantly associated with the risk developing IRIS-CDC.
Fig. 1.Manhattan plot visualizing genome-wide association of 61 cutaneous squamous cell carcinoma (cSCC)-organ transplant recipients (OTRs) and 908 skin cancer negative-OTRs, showing -log10 p-value SNPtest along chromosomes.Horizontal red line represents the significant threshold 5×10 -8 .Arrow indicates single nucleotide polymorphism rs34567942 with most prominent p-value.
Papillophlebitis is an uncommon disease in clinical practice. We would like to present a case of 29-year-old patient with atypical orbital pain and flashings, presenting relative afferent pupillary defect already typical the entity: ophthalmoscopic picture fundus big blind spot perimetry. complex interdisciplinary diagnostic process that excludes general diseases such as hypertension, diabetes, coagulation disorders neurological causes. leave only identifiable abnormality potential source...
Abstract Betel quid is one of the most commonly used psychoactive substances in world, especially among Asian communities, just after caffeine, nicotine and alcohol. The mixture that chewed usually contains betel leaves, areca nut slaked lime, nonetheless, its ingredients preparation manner tend to vary. Areca four main alkaloids - arecoline, arecaidyne, guvacine guvacoline are responsible for effects. act chewing might have a negative impact on an overall health can cause pathological...