A5053618964- Bee Products Chemical Analysis
- Chemotherapy-induced cardiotoxicity and mitigation
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Smoking Behavior and Cessation
- Birth, Development, and Health
- Nutrition and Health Studies
- Cancer Treatment and Pharmacology
- Hedgehog Signaling Pathway Studies
- Inflammatory mediators and NSAID effects
- Liver Disease Diagnosis and Treatment
- Healthcare and Venom Research
- Reproductive Biology and Fertility
- Sarcoma Diagnosis and Treatment
- Sperm and Testicular Function
- Pesticide Exposure and Toxicity
- Eicosanoids and Hypertension Pharmacology
- Immune Cell Function and Interaction
- Berberine and alkaloids research
- Ovarian cancer diagnosis and treatment
- Nicotinic Acetylcholine Receptors Study
- PI3K/AKT/mTOR signaling in cancer
- Health, Work, and Social Studies in Poland
- Coffee research and impacts
- Phytochemistry and Biological Activities
Medical University of Lublin
2015-2024
The p53 protein is an important factor of many intra- and extracellular processes. This regulates the repair cellular DNA induces apoptosis. It also responsible for regulation senescence cell entering subsequent stages cycle. involved in inhibiting angiogenesis induction oxidative shock. In our study, we examined activity uterine epithelial cells rats treated with cladribine. Its action mainly based on apoptosis induction. We compared a high index active mechanisms proliferation index....
The aim of the study was to evaluate effect resveratrol in doxorubicin-induced cardiac and hepatic toxicity. Doxorubicin administered once a week throughout period 7 weeks with 1.0 or 2.0 mg/kg body weight concomitantly (20 feed). Heart liver toxicity histologically biochemically evaluated. Resveratrol protected from heart lipid peroxidation caused by 1 mg doxorubicin it sharply diminished superoxide dismutase activity. An insignificant on level activity observed hearts rats higher dose...
Chronic environmental stress is associated with reactive oxygen species (ROS) overproduction and the pathogenesis of depression. The purpose this study was to evaluate biochemical molecular changes ROS generation in brains rats submitted chronic variable stress. Male Wistar (50-55 days old, weighing 200-250 g) were divided two groups (n = 10): control stressed. Rats stressed group exposed conditions for 40 days. animals decapitated brain samples collected. In prefrontal cortex, we measured...
Alterations in microRNAs expression have been proposed to play role endometrial cancer pathogenesis. Dicer and Drosha are main regulators of microRNA biogenesis deregulation their has indicated as a possible cause alterations observed various cancers. The objective this study was investigate genes analyze the impact clinicopathological characteristics on expression. Fresh tissue samples were collected from 44 patients (26 endometroid carcinoma 18 controls). Clinical pathological data...
Samples of uterine leiomyomatis and normal tissues taken from patients after surgery were investigated using the Positron Annihilation Lifetime Spectroscopy (PALS).Significant differences in all PALS parameters between diseased observed.For studied patients, it was found that values free annihilation orthopositronium lifetime are larger for tumorous than healthy ones.For most intensity ortho-positronium smaller tissues.For first time, this kind studies, 3γ fraction positron determined to...
Introduction: Nicotine stimulates fibroblast proliferation while increasing inflammation and fibrosis of tissues. The cannabinoid receptor 1 (CB1R) is mainly located in the CNS, 2 (CB2R) immune cells within body. CB2R regulates inflammatory processes function. Purpose: We investigated impact agonist, JWH 133 antagonist, AM630 on lung tissue, applied directly before nicotine application. Material methods: 40 mice were placed into 4 groups. experimental groups received intraperitoneally at a...
The use of electronic cigarettes increases as a supposedly healthier form nicotine consumption, but safety vaping remains uncertain. In this study, we assessed whether the risk infertility in male rats. Malformations sperm morphology were more frequent nicotine-exposed groups than control group. Vacuolization seminiferous epithelium, reduction spermatogenesis, increased apoptosis spermatogonia and spermatocytes, acceleration degeneration testes observed. reproductive organs are slightly less...
The positron annihilation lifetime spectroscopy was applied to the samples of human uterine leiomyomas and normal myometrium tissues taken from selected place uterus during a surgery.The method indicated differences in values measured parameters (lifetimes intensities) between healthy diseased tissue samples.The additional measurements were performed either darkness or presence visible light which influenced free radicals present both kind and, as result, made changes o-Ps decay intensity values.
Electronic cigarettes are becoming increasingly common as a form of nicotine usage, known vaping. Numerous studies have demonstrated that using electronic may lead to dependence and has potentially harmful impact on health. The present study compared the conventional lung tissue. experiment included 30 male Wistar rats. animals were divided into three groups: Group A was exposed cigarette liquid vapour; group B smoke; C constituted control without exposition nicotine. In both experimental...
Background: Doxorubicin (DOX) is an anticancer drug displaying cardiac and hepatic adverse effects mostly dependent on oxidative stress. Green tea (GT) has been reported to play a protective role in diseases resulting from stress.Objective: The objective of this study was evaluate if GT protects against DOX-induced stress, heart liver morphological changes, metabolic disorders.Methods: Male Wistar rats received intraperitoneal injection DOX (1.0 or 2.0 mg/kg b.w.) for 7 weeks concomitantly...
The fast-growing use of nanomaterials in everyday life raises the question about safety their use. Unfortunately, risks associated with nanoparticles (NPs) have not yet been fully assessed. majority studies conducted so far at molecular and cellular level focused on a single-type exposure, assuming that NPs act as only factor. In natural environment, however, we are likely exposed to mixture nanoparticles, whose interactions may modulate impact living organisms. This study aimed evaluate...
The aim of this study was to summarize the current state knowledge on pesticide-related fertility problems and disadventeges childrens due prenatal pesticides exposure. Available literature analyzed. Due extent issue, focuses epidemiological studies conducted in humans, despite evidence from vitro animal studies. It seems certain that exposure harmful chemicals is one factors may cause a decline with conceiving, whereas during pregnancy can impair foetal development. Prenatal also result...
Cytochrome P450 NADPH-reductase (P450R), inducible synthase (iNOS) and xanthine oxidase play an important role in the antracycline-related cardiotoxicity. The expression of P450R iNOS is regulated by triiodothyronine. aim this study was to evaluate effect methimazole-induced hypothyreosis on oxidative stress secondary doxorubicin administration. 48 hours after methimazole giving cessation, rats were exposed (2.0, 5.0 15 mg/kg). Blood heart collected 4, 96 h drug Animals exclusively or...
Cladribine has been used in the treatment of hairy cell leukemia for about 30 years. In addition, number indications application 2-CdA is constantly increasing. The with cladribine, younger persons and even children, appears to be a major factor stimulating more exact recognition its activities. However, till now, little known impact cladribine on reproductive system. aim study was evaluate immunohistochemical expression proliferation apoptosis markers ovarian surface epithelial (OSE) cells....
Silver nanoparticles (AgNPs) are used in many fields of industry and medicine. Despite the well-established antimicrobial activity, AgNPs foreseen to be as anticancer drugs due unusual feature-inability induce drug resistance cancer cells. The aim study was assess biological activity against MDA-MB-436 cells were derived from triple-negative breast cancer, a type with poor prognosis is particularly difficult cure. toxic probable mechanism toxicity induction oxidative stress. These promising...
Abstract Lepidium meyenii , commonly known as Maca, is a Peruvian plant that grows high in the Andes, areas over 4,000 meters above sea level. Its composition contains almost all of essential amino acids and twenty fatty needed by man, well many vitamins, minerals several sterols glucosinolates. The specific unique unsaturated amides found only this are macaenes macamides. Most valuable ingredients contained within hypocotyls. Maca comes three forms, based on its root colour, yellow, red...
Doxorubicin (DOX) causes long-term cardiomyopathy that is dependent on oxidative stress and contractility disorders. Tirapazamine (TP), an experimental adjuvant drug, passes the same red-ox transformation as DOX. The aim of study was to evaluate effect tirapazamine stress, contractile protein level, cardiomyocyte necrosis in rats administered doxorubicin. Rats were intraperitoneally injected six times once a week with two doses, 5 (5TP) 10 mg/kg (10TP), while doxorubicin dose 1.8 (DOX)....
ABSTRACT Nonsteroidal anti-inflammatory drugs (NSAIDs) are used by millions of people worldwide to neutralize pain that is different origin, as well treat fever and inflammation. However, NSAIDs misuse/overuse can induce many adverse effects some potentially serious complications. The aim the our study was ascertain young people’s knowledge about non-steroidal drugs. research tool a questionnaire. This carried out among students Medical University in Lublin, it involved 236 persons an...