A5040907033- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and Mental Health
- Blood transfusion and management
- Cardiac Imaging and Diagnostics
- Ultrasound in Clinical Applications
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Cardiac Health and Mental Health
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Nutrition and Health in Aging
- Respiratory Support and Mechanisms
- Clinical Nutrition and Gastroenterology
- Climate Change and Health Impacts
- Sex and Gender in Healthcare
- Platelet Disorders and Treatments
- Pulmonary Hypertension Research and Treatments
- Healthcare professionals’ stress and burnout
- Cardiac electrophysiology and arrhythmias
University Hospital of Basel
2018-2025
University of Basel
2019-2025
Hospital Base
2023
Slagelse Hospital
2021
Zealand University Hospital
2021
Frederiksberg Hospital
2021
Aalborg University Hospital
2021
Aarhus University Hospital
2021
Hvidovre Hospital
2021
Herlev Hospital
2021
Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated supplemental oxygen, but benefits and harms of different oxygenation targets unclear. We hypothesized that using a lower target for partial pressure arterial oxygen (Pao2) would result mortality than higher target.
Importance Supplemental oxygen is ubiquitously used in patients with COVID-19 and severe hypoxemia, but a lower dose may be beneficial. Objective To assess the effects of targeting Pa o 2 60 mm Hg vs 90 hypoxemia intensive care unit (ICU). Design, Setting, Participants Multicenter randomized clinical trial including 726 adults receiving at least 10 L/min or mechanical ventilation 11 ICUs Europe from August 2020 to March 2023. The was prematurely stopped prior outcome assessment due slow...
It is currently unclear whether management and outcomes of critically ill patients differ between men women. We sought to assess the influence age, sex diagnoses on probability intensive care provision in cardio- neurovascular a large nationwide cohort Switzerland. Retrospective analysis 450,948 adult with neuro- cardiovascular disease admitted all hospitals Switzerland 01/2012 12/2016 using Bayesian modeling. For populations, median ages at admission were consistently higher for women than...
Background Women are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Aim We assessed the sex gender in a Swiss population. Method Our multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients hospitalised patients PCR-confirmed infection. Results Among...
Coronavirus disease 2019 (COVID-19) leads to inflammatory cytokine release, which can downregulate the expression of metabolizing enzymes. This cascade affects drug concentrations in plasma. We investigated association between lopinavir (LPV) and hydroxychloroquine (HCQ) plasma levels acute-phase inflammation marker C-reactive protein (CRP). LPV 92 patients hospitalized at our institution were prospectively collected. Lopinavir-ritonavir was administered every 12 hours, 800/200 mg on day 1...
Abstract Background The Sequential Organ Failure Assessment (SOFA) score is an important tool in diagnosing sepsis and quantifying organ dysfunction. However, despite emerging evidence of differences pathophysiology between women men, sex currently not being considered the SOFA score. We aimed to investigate potential sex-specific dysfunction, as measured by score, patients with or septic shock explore outcome associations. Methods Retrospective analysis prospectively enrolled ICU admitted...
Background The effect of age and gender on left ventricular ( LV ) size, muscle mass, systolic function as determined by two‐dimensional echocardiography has not yet been investigated in a large population. Methods Normal transthoracic studies 5307 subjects (47% males) performed between March 1990 December 2011 were analyzed. end‐diastolic volume index LVEDVI ), mass LVMMI ejection fraction LVEF fractional shortening LVFS compared different groups. Results increased females from 66.4 ± 1.3...
Abstract Background and Aims Increasing data suggest that stress-related neural activity (SNA) is associated with subsequent major adverse cardiovascular events (MACE) may represent a therapeutic target. Current evidence exclusively based on populations from the U.S. Asia where limited information about disease risk was available. This study sought to investigate whether SNA imaging has clinical value in well-characterized cohort of patients Europe. Methods In this single-centre study, total...
Objectives: To report the use of common femoral vein Doppler interrogation as a simple technique to diagnose right ventricular dysfunction. Design: Case report. Setting: Cardiac surgical ICU. Patients: Postoperative cardiac patients. Interventions: Common pulsed-wave and color examination associated with hepatic, portal, renal venous measurement were obtained in both patients before after treatment patient number 1. In addition, pressure waveform was 2. Measurements Main Results: The obtain...
Abstract Background Women are overrepresented amongst individuals suffering from post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Methods Findings By using Bayesian models comprising >200 co-variates, we assessed the social context in addition to biological data a multi-centre prospective cohort study 2927 (46% women) Switzerland. more...
Abstract Aims Impact of skin mottling has been poorly studied in patients admitted for cardiogenic shock. This study aimed to address this issue and identify determinants 30-day 1-year mortality a large shock cohort all etiologies. Methods results FRENSHOCK is prospective multicenter observational registry conducted French critical care units between April October, 2016. Among the 772 enrolled (mean age 65.7 ± 14.9 years; 71.5% male), 660 had assessed at admission (85.5%) with almost 39%...
Abstract Background Conflicting findings exist regarding the influence of sex on development, treatment, course, and outcome status epilepticus (SE). Our study aimed to investigate sex-related disparities in adult SE patients, focusing disease at two Swiss academic medical centers. Methods In this retrospective study, patients treated for care centers from Basel Geneva 2015 2021 were included. Primary outcomes return premorbid neurologic function, death during hospital stay 30 days....
Conflicting data exist regarding sex-specific outcomes after cardiac arrest. This study investigates sex disparities in the provision of critical care and in-hospital (IHCA) out-of-hospital arrest (OHCA) patients. Analysis adult patients admitted to certified Swiss intensive units (ICUs) (01/2008–12/2022) using nationwide prospective ICU registry. The primary outcome was mortality, with secondary including admission probability advanced treatment provision. Among 41,733 individuals (34.9%...
Cardiogenic shock (CS) remains a critical condition with high mortality rates despite advances in treatment. This study aims to comprehensively evaluate both macrocirculatory and tissue perfusion variables over the initial 24 h post-admission determine their impact on patient prognosis identify potential hemodynamic thresholds for optimal outcomes. Secondary were explore correlation between variables. is post hoc analysis of data from two prospective studies, OptimaCC (NCT01367743)...
Timely management of acute myocardial infarction (AMI) and stroke has undergone impressive progress during the last decade. However, it is currently unknown whether both sexes have profited equally from improved strategies. We sought to analyze sex-specific temporal trends in intensive care unit (ICU) admission mortality younger patients presenting with AMI or Switzerland.Retrospective analysis 16,954 aged 18 ≤ 52 years admitted Swiss ICUs between 01/2008 12/2019.Over a period 12 years, ICU...