The authors investigated the effect of a single preoperative bolus erythropoietin on perioperative transfusion requirement and erythropoiesis in patients with anemia undergoing valvular heart surgery.In this prospective, single-site, single-blinded, randomized, parallel-arm controlled trial, 74 were randomly allocated to either or control group. group received 500 IU/kg 200 mg iron sucrose intravenously 1 day before surgery. an equivalent volume normal saline. primary endpoint was assessed...

Postoperative cognitive dysfunction (POCD) commonly develops after cardiac surgery affecting patients' outcome. Cerebral oximetry noninvasively measures regional cerebral oxygen saturation (rSO(2)) and significant correlation has been reported between intraoperative desaturation POCD, as well outcome following coronary artery bypass grafting. However, evidence is limited in valvular heart (VHS). We investigated the relationship of rSO(2) values with POCD length postoperative hospitalization...

A prospective, randomized, controlled, and double-blind trial.To evaluate the effects of 2 different doses perioperative pregabalin administration, twice on day surgery, acute postoperative pain after spinal surgery.Besides its well-established role neuropathic pain, seems to be a promising adjunct multimodal analgesic regimen following surgery. No comprehensive data exist regarding optimal dosage reducing opioid consumption in surgery.Patients were randomly assigned 1 3 groups. The placebo...

Propofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is lacking. Here we studied the effect of propofol anesthesia on occurrence acute kidney following heart surgery with cardiopulmonary bypass. One hundred and twelve patients who underwent valvular were randomized receive either or sevoflurane anesthesia, both sufentanil. Using Acute Kidney Injury Network criteria, significantly fewer developed postoperatively in group...

In this study, we examined the relationship between postoperative cognitive dysfunction (POCD) and intraoperative regional cerebral oxygen saturation (rSO2) in elderly patients undergoing spinal surgery.We enrolled 87 older than 65 years. All were tested using a battery of function tests (Korean Mini-Mental State Examination visuomotor test Dynamic Lowenstein Occupational Therapy Cognitive Assessment-Geriatric Version) day before their surgical operation on seventh day. Our threshold for...

Dexmedetomidine, an α2 adrenergic receptor agonist, has analgesic, sedative and sympatholytic properties, with a lack of respiratory depression. It is licensed only for intensive care sedation.The objective this study to investigate whether intravenous (i.v.) patient-controlled analgesia (PCA) dexmedetomidine added fentanyl-based drug mixture could reduce postoperative nausea vomiting (PONV) in highly susceptible patients undergoing lumbar spinal surgery.A randomised, double-blinded study.At...

Acute kidney injury frequently occurs after cardiac surgery, and is primarily attributed to renal ischemia-reperfusion (I/R) inflammation from surgery cardiopulmonary bypass. Vitamin C, an antioxidant that often depleted in critically ill patients, could potentially mitigate I/R-induced oxidative stress at high doses. We investigated the effectiveness of high-dose vitamin C preventing injury. The ideal time optimal dosage for administration were determined a two-phase experiment on...

Objectives. This qualitative, ethnographic study explores the character and extent of medical choice for life-extending procedures on older adults. It examines sociomedical features treatment that shape health care provider understandings nature choice, it illustrates effects patterns patients' perspectives their options life extension.

In Brief Study Design. A prospective, randomized, double-blind clinical trial. Objective. To compare the effect of ramosetron with that ondansetron on opioid-based IV patient-controlled analgesia (PCA) related postoperative nausea and vomiting (PONV) in highly susceptible patients after lumbar spine surgery. Summary Background Data. Optimal pain management is important to facilitate early mobilization Opioid associated a high incidence PONV. Among currently available 5-hydroxytryptamine...

Abstract Introduction Recombinant human erythropoietin (EPO) is known to provide organ protection against ischemia-reperfusion injury through its pleiotropic properties. The aim of this single-site, randomized, case-controlled, and double-blind study was investigate the effect pre-emptive EPO administration on incidence postoperative acute kidney (AKI) in patients with risk factors for AKI undergoing complex valvular heart surgery. Methods We studied ninety-eight preoperative AKI. were...

Anaesthesia is required for catheter ablation of atrial fibrillation (A-fib) to achieve patient comfort and immobilization avoid map shifts. This study compared the analgesic sedative efficacies dexmedetomidine–remifentanil with those midazolam–remifentanil A-fib. Ninety patients were randomized receive either intermittent midazolam boluses (1–2 mg) 3.6–7.2 µg/kg/h remifentanil (MR group) or dexmedetomidine 0.2–0.7 after a loading dose 1 µg/kg 1.2–2.4 (DR group). The sedation level assessed...

Emerging evidence indicates the pronounced role of inflammasome activation linked to reactive oxygen species (ROS) in sterile inflammatory response triggered by ischemia/reperfusion (I/R) injury. Ethyl pyruvate (EP) is an antioxidant and conveys myocardial protection against I/R injury, while exact mechanisms remain elusive. We aimed investigate effect EP on injury through related ROS regulation. The rats were randomly assigned four groups: (1) sham, (2) I/R-control (IRC), (3)...