André Denault

ORCID: 0000-0003-0634-6291
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About
Contact & Profiles
Research Areas
  • Hemodynamic Monitoring and Therapy
  • Cardiac, Anesthesia and Surgical Outcomes
  • Ultrasound in Clinical Applications
  • Pulmonary Hypertension Research and Treatments
  • Cardiac Valve Diseases and Treatments
  • Cardiovascular Function and Risk Factors
  • Cardiac Arrest and Resuscitation
  • Intensive Care Unit Cognitive Disorders
  • Mechanical Circulatory Support Devices
  • Heart Failure Treatment and Management
  • Cardiac Imaging and Diagnostics
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Congenital Heart Disease Studies
  • Cardiac and Coronary Surgery Techniques
  • Cardiac Structural Anomalies and Repair
  • Optical Imaging and Spectroscopy Techniques
  • Non-Invasive Vital Sign Monitoring
  • Anesthesia and Sedative Agents
  • Infective Endocarditis Diagnosis and Management
  • Sepsis Diagnosis and Treatment
  • Aortic Disease and Treatment Approaches
  • Respiratory Support and Mechanisms
  • Anesthesia and Neurotoxicity Research
  • Liver Disease and Transplantation
  • Heart Rate Variability and Autonomic Control

Montreal Heart Institute
2016-2025

Université de Montréal
2016-2025

Centre Hospitalier de l’Université de Montréal
2014-2023

Fondation Institut de Cardiologie de Montréal
2023

University of Debrecen
2021

Fundación Valle del Lili
2021

University of Cambridge
2021

Johns Hopkins Medicine
2021

Johns Hopkins University
2021

Hospital Posadas
2021

Abstract Background Organ congestion is a mediator of adverse outcomes in critically ill patients. Point-Of-Care ultrasound (POCUS) widely available and could enable clinicians to detect signs venous at the bedside. The aim this study was develop several grading system prototypes using POCUS determine their respective ability predict acute kidney injury (AKI) after cardiac surgery. This post-hoc analysis single-center prospective 145 patients undergoing surgery for which repeated daily...

10.1186/s13089-020-00163-w article EN cc-by The Ultrasound Journal 2020-04-08

Near-infrared spectroscopy (NIRS) is a technique that can be used as noninvasive and continuous monitor of the balance between cerebral oxygen delivery consumption. The authors develop propose an algorithm for use NIRS based on optimizing factors affect supply/demand. These are position vascular cannula, perfusion pressure, arterial content, partial pressure carbon dioxide, haemoglobin, cardiac output, metabolic rate oxygen. Dissemination useful treatment primary purpose this article....

10.1177/1089253207311685 article EN Seminars in Cardiothoracic and Vascular Anesthesia 2007-12-01

Evidence suggests a role for excessive inflammation in COVID-19 complications. Colchicine is an oral anti-inflammatory medication beneficial gout, pericarditis, and coronary disease. We aimed to investigate the effect of colchicine on composite COVID-19-related death or hospital admission.The present study phase 3, randomised, double-blind, adaptive, placebo-controlled, multicentre trial. The was done Brazil, Canada, Greece, South Africa, Spain, USA, led by Montreal Heart Institute. Patients...

10.1016/s2213-2600(21)00222-8 article EN cc-by The Lancet Respiratory Medicine 2021-05-27

Cerebral oxygen desaturation during cardiac surgery has been associated with adverse perioperative outcomes. Before a large multicenter randomized controlled trial (RCT) on the impact of preventing desaturations outcomes, authors undertook prospective, parallel-arm, feasibility RCT to determine whether an intervention algorithm could prevent desaturations.Eight Canadian sites 201 patients between April 2012 and October 2013. The primary outcome was success rate reversing cerebral below 10%...

10.1097/aln.0000000000001029 article EN Anesthesiology 2016-01-24

Background Acute kidney injury ( AKI ) after cardiac surgery is associated with adverse outcomes. Venous congestion can impair function, but few tools are available to assess its impact at the bedside. The objective of this study was determine whether portal flow pulsatility and alterations in intrarenal venous assessed by Point‐Of‐Care ultrasound surgery. Methods Results This single‐center prospective cohort recruited patients undergoing cardiopulmonary bypass. Hepatic renal Doppler...

10.1161/jaha.118.009961 article EN cc-by-nc-nd Journal of the American Heart Association 2018-09-20

Although much is known about the risk factors for poor outcome in patients hospitalized with acute heart failure and left ventricular dysfunction, less syndrome of primarily affecting right ventricle (acute failure).By using Stanford Hospital's pulmonary hypertension database, we identified consecutive hospitalizations PAH. We used longitudinal regression analysis generalized estimating equations method to identify associated an increased likelihood 90-day mortality or urgent...

10.1161/circheartfailure.110.949933 article EN Circulation Heart Failure 2011-09-10

Orthotopic liver transplantation (OLT) has been associated with major blood loss and the need for product transfusions. During last decade, improved surgical anesthetic management reduced intraoperative A first report from our group published in 2005 described a mean transfusion rate of 0.3 red cell (RBC) unit per patient 61 consecutive OLTs. Of these patients, 80.3% did not receive any product. The interventions leading to those results were combination fluid restriction, phlebotomy,...

10.1097/tp.0b013e318250fc25 article EN Transplantation 2012-05-22

ABSTRACT Background Evidence suggests the role of an inflammatory storm in COVID-19 complications. Colchicine is orally administered, anti-inflammatory medication beneficial gout, pericarditis and coronary disease. Methods We performed a randomized, double-blind trial involving non-hospitalized patients with diagnosed by polymerase chain reaction (PCR) testing or clinical criteria. The were randomly assigned to receive colchicine (0.5 mg twice daily for 3 days once thereafter) placebo 30...

10.1101/2021.01.26.21250494 preprint EN cc-by-nc medRxiv (Cold Spring Harbor Laboratory) 2021-01-27

The use of processed electroencephalography (pEEG) for depth sedation (DOS) monitoring is increasing in anesthesia; however, how to this type critical care adult patients within the intensive unit (ICU) remains unclear.A multidisciplinary panel international experts consisting 21 clinicians involved DOS ICU was carefully selected on basis their expertise neurocritical and neuroanesthesiology. Panelists were assigned four domains (techniques [EEG] monitoring, patient selection, EEG monitors,...

10.1007/s12028-022-01565-5 article EN cc-by Neurocritical Care 2022-07-27
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