A5026234787- Cardiac Imaging and Diagnostics
- Viral Infections and Immunology Research
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- SARS-CoV-2 and COVID-19 Research
- Radiation Dose and Imaging
- Pericarditis and Cardiac Tamponade
- Cardiomyopathy and Myosin Studies
- Diabetes and associated disorders
- Advanced X-ray and CT Imaging
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Impact on Reproduction
- Cardiac Arrhythmias and Treatments
- Thermal Regulation in Medicine
- Ultrasound in Clinical Applications
- Coronary Artery Anomalies
- Cardiovascular Disease and Adiposity
- Optimism, Hope, and Well-being
- Atrial Fibrillation Management and Outcomes
University Hospital of Zurich
2018-2024
Kantonsspital Baden
2020-2022
University of Zurich
2019-2022
Charité - Universitätsmedizin Berlin
2022
Zurich Heart House
2017-2020
Swiss National Science Foundation
2020
OPO-Stiftung
2020
Novartis Foundation
2020
Harefield Hospital
2019
Imperial College London
2019
Background Women are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Aim We assessed the sex gender in a Swiss population. Method Our multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients hospitalised patients PCR-confirmed infection. Results Among...
BackgroundSince the beginning of coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading severe clinical course in patients infected with acute respiratory syndrome 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have suggested as potential genetic host factors that affect individual immune response SARS-CoV-2. We sought evaluate this hypothesis by conducting a multicenter study using HLA...
Objective Clinical data on the effect of non-steroidal anti-inflammatory drugs (NSAIDs) in myopericarditis are limited. Since NSAIDs standard therapy pericarditis, we retrospectively investigated their safety myopericarditis. Methods In a retrospective case-control study, identified 60 patients with from September 2010 to August 2017. Diagnosis was based clinical criteria, elevated high-sensitivity troponin T and cardiac magnetic resonance imaging (CMR). All received heart failure if...
Abstract Background Women are overrepresented amongst individuals suffering from post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Methods Findings By using Bayesian models comprising >200 co-variates, we assessed the social context in addition to biological data a multi-centre prospective cohort study 2927 (46% women) Switzerland. more...
Cardiovascular outcomes of women with coronary artery disease (CAD) are perceived as relatively worse when compared to men. Amygdalar metabolic activity has recently been shown independently predict cardiovascular events in patients without known disease. Given that traditional algorithms for risk prediction perform than men, we sought assess sex-specific associations between amygdalar and cardiac dysfunction suspected or CAD.This retrospective study included 302 (mean age 66.8 ± 10.2 years,...
Cardiovascular disorders such as heart failure are leading causes of mortality. Patient stratification via identification novel biomarkers could improve management cardiovascular diseases complex etiologies. Long-noncoding RNAs (lncRNAs) highly tissue-specific in nature and have emerged important human diseases. In this study, we aimed to identify cardiac-enriched lncRNAs potential for conditions.Deep RNA sequencing quantitative PCR identified differentially expressed between failing...
Objectives: Understanding sex differences in myocarditis is crucial to improve clinical care. We sought investigate focusing on presentation and laboratory parameters. Methods: From 2011 2018, 77 patients were diagnosed with according European Society of Cardiology (ESC) criteria available clinical, laboratory, cardiac magnetic resonance imaging data. First, we investigated parameters the entire cohort patients. Second, focused acute (n = 51) defined as recent symptom onset (≤10 days)....
Systematic work-up of patients with myocardial infarction and non-obstructive coronary artery disease (MINOCA) using cardiac magnetic resonance imaging (CMR) led to a more than six-fold increase in the detection rate myocarditis. In this study, we expanded on our prior two-year analysis by including preceding subsequent years.
Background: Polymerase chain reaction analyses of cardiac tissues have detected viral sequences in up to 67% cases myocarditis. However, viruses not been implicated giant cell myocarditis (GCM). Furthermore, efforts detect unsuccessful more accessible samples such as peripheral blood. Methods: We used Virome Capture Sequencing for Vertbrate Viruses (VirCapSeq-VERT), a method that simultaneously screens all known vertebrate viruses, investigate 33 patients with investigated blood mononuclear...
Inadequate coronary adenosine response is a potential cause for false negative ischemia testing. Recently, the splenic switch-off (SSO) sign has been identified as promising tool to ascertain efficacy of during vasodilator stress cardiovascular magnetic resonance imaging (CMR). We assessed value SSO predict response, defined an increase in myocardial blood flow (MBF) quantitative perfusion 13 N-ammonia positron emission tomography (PET). prospectively enrolled 64 patients who underwent...
Abstract International cardiovascular society recommendations to return sports activities following acute myocarditis are based on expert consensus in the absence of prospective studies. We prospectively enrolled 30 patients with newly diagnosed clinical parameters, laboratory measurements and cardiac magnetic resonance imaging mildly reduced or preserved left ventricular ejection fraction (LVEF) a follow-up 12 months. Cessation physical activity was recommended for 3 The average age 35...
No methodology is available to distinguish truly reduced myocardial flow reserve (MFR) in positron emission tomography perfusion imaging (PET MPI) from seemingly impaired MFR due inadequate adenosine response. The adenosine-induced splenic switch-off (SSO) sign has been proposed as a potential marker for adequate response cardiac magnetic resonance (CMR). We assessed the feasibility of detecting SSO nitrogen-13 ammonia PET MPI using CMR standard reference. Fifty patients underwent...
Abstract Purpose To assess the prognostic value of regional quantitative myocardial flow measures as assessed by 13 N-ammonia positron emission tomography (PET) perfusion imaging (MPI) in patients with suspected coronary artery disease (CAD). Methods We retrospectively included 150 consecutive CAD who underwent clinically indicated PET-MPI and did not undergo revascularization within 90 days PET-MPI. The presence or absence a decreased global reserve (i.e., MFR < 2) well ≥ 2 adjacent...
Abstract Purpose Whether myocardial inflammation causes long-term sequelae potentially affecting blood flow (MBF) is unknown. We aimed to assess the effect of on quantitative MBF parameters, as assessed by 13N-ammonia positron emission tomography perfusion imaging (PET-MPI) late after myocarditis. Methods Fifty patients with a history myocarditis underwent cardiac magnetic resonance (CMR) at diagnosis and PET/MR follow-up least 6 months later. Segmental MBF, reserve (MFR), washout were...