Carolyn M. Hendrickson
A5017038212- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Trauma and Emergency Care Studies
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Cardiac Arrest and Resuscitation
- Gut microbiota and health
- Non-Invasive Vital Sign Monitoring
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Thermal Regulation in Medicine
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Metabolomics and Mass Spectrometry Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Impact on Reproduction
- Hemodynamic Monitoring and Therapy
- Healthcare Technology and Patient Monitoring
- Respiratory viral infections research
- Clostridium difficile and Clostridium perfringens research
- Immune responses and vaccinations
- Inflammation biomarkers and pathways
University of California, San Francisco
2015-2025
San Francisco General Hospital
2015-2025
University of California System
2018-2025
National Heart Lung and Blood Institute
2023-2024
University of Washington
2024
Association Clinique et Thérapeutique Infantile du Val de Marne
2022-2023
Center for Rheumatology
2022
Advanced ENT and Allergy
2022
Cardiovascular Institute Hospital
2022
University Health Network
2021
Thrombosis and inflammation may contribute to morbidity mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill Covid-19.
Thrombosis and inflammation may contribute to the risk of death complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation improve outcomes in noncritically ill who are hospitalized Covid-19.In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned were Covid-19 not critically (which was defined as an absence critical care-level organ support at enrollment) receive pragmatically regimens either...
Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals1-3, many others experience milder symptoms. Here, to gain a more comprehensive understanding of the distinction between mild phenotypes pathology disease 2019 (COVID-19) its origins, we performed whole-blood-preserving single-cell analysis protocol integrate contributions from all major immune cell types blood-including neutrophils, monocytes,...
Neutralizing autoantibodies against type I interferons (IFNs) have been found in some patients with critical coronavirus disease 2019 (COVID-19), the caused by severe acute respiratory syndrome 2 (SARS-CoV-2). However, prevalence of these antibodies, their longitudinal dynamics across severity scale, and functional effects on circulating leukocytes remain unknown. Here, 284 COVID-19, we IFN–specific peripheral blood samples from 19% 6% disease. We no IFN individuals moderate Longitudinal...
Platelets represent a potential therapeutic target for improved clinical outcomes in patients with COVID-19.
We carried out integrated host and pathogen metagenomic RNA DNA next generation sequencing (mNGS) of whole blood (n = 221) plasma 138) from critically ill patients following hospital admission. assigned into sepsis groups on the basis clinical microbiological criteria. From whole-blood gene expression data, we distinguished with non-infectious systemic inflammatory conditions using a trained bagged support vector machine (bSVM) classifier (area under receiver operating characteristic curve...
Importance Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity treatment effect (HTE) across individuals. Better understanding HTE could facilitate individualized decision-making. Objective To evaluate for and compare approaches assessing HTE. Design, Setting, Participants Exploratory analysis a multiplatform adaptive RCT vs usual care pharmacologic thromboprophylaxis 3320 enrolled...
BackgroundSince the beginning of coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading severe clinical course in patients infected with acute respiratory syndrome 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have suggested as potential genetic host factors that affect individual immune response SARS-CoV-2. We sought evaluate this hypothesis by conducting a multicenter study using HLA...
Using latent class analysis (LCA), two subphenotypes of acute respiratory distress syndrome (ARDS) have consistently been identified in five randomised controlled trials (RCTs), with distinct biological characteristics, divergent outcomes and differential treatment responses to interventions. Their existence unselected populations ARDS remains unknown. We sought identify observational cohorts using LCA.LCA was independently applied patients from prospective admitted the intensive care unit,...
Abstract The immunological features that distinguish COVID-19-associated acute respiratory distress syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report the results comparative lower tract transcriptional profiling tracheal aspirate 52 critically ill patients with COVID-19 or etiologies, as well controls without ARDS. In contrast to a “cytokine storm,” observe reduced proinflammatory gene expression in when compared due causes. is characterized by...
Rationale: Autopsy and biomarker studies suggest that endotheliopathy contributes to coronavirus disease (COVID-19)-associated acute respiratory distress syndrome. However, the effects of COVID-19 on lung endothelium are not well defined. We hypothesized is caused by circulating host factors direct endothelial infection severe syndrome 2 (SARS-CoV-2). Objectives: aimed determine SARS-CoV-2 or sera from patients with permeability inflammatory activation microvascular cells. Methods: Human...
Retrospective clinical trials of pulse oximeter accuracy report more frequent missed diagnoses hypoxemia in hospitalized Black patients than White patients, differences that may contribute to racial disparities health and care. studies have limitations including mistiming blood samples readings, inconsistent use functional versus fractional saturation, self-reported race used as a surrogate for skin color. Our objective was prospectively measure the contributions pigmentation, perfusion...
Two molecular phenotypes of sepsis and acute respiratory distress syndrome, termed hyperinflammatory hypoinflammatory, have been consistently identified by latent class analysis in numerous cohorts, with widely divergent clinical outcomes differential responses to some treatments; however, the key biological differences between these remain poorly understood.
Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation lipids and other substrates.
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the mechanisms behind this relationship have remained incompletely understood. To address this, we evaluated impact of aging on host immune response in blood and upper airway, as well nasal microbiome prospective, multicenter cohort 1031 vaccine-naïve patients hospitalized COVID-19 between 18 96 years old. We performed mass cytometry, serum protein profiling, anti–severe acute respiratory syndrome 2 (SARS-CoV-2)...
Abstract Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim understand the host immunologic and microbial features of COVID-19 in recipients by leveraging a prospective multicenter cohort 86 age- sex-matched with 172 non-transplant controls. find that higher nasal SARS-CoV-2 viral abundance impaired clearance, lower anti-spike IgG levels. In addition, exhibit...
Experimental models of sepsis in small and large animals a variety vitro preparations have established several basic mechanisms that drive endothelial injury. This review is focused on what can be learned from the results clinical studies plasma biomarkers injury inflammation patients with sepsis. There excellent evidence elevated levels injury, including von Willebrand factor antigen (VWF), angiopoietin‐2 (Ang‐2), soluble fms‐like tyrosine kinase 1 (sFLT‐1), inflammation, especially...
Abstract Background Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) sepsis. Attributable mortality of ARDS each phenotype sepsis is yet to be determined. We aimed estimate the population attributable fraction death from (PAF ) hypoinflammatory sepsis, determine primary cause within phenotype. Methods studied 1737 patients with two prospective cohorts. Patients were previously assigned or using latent class analysis....
BACKGROUND Acute respiratory distress syndrome (ARDS) is common after traumatic brain injury (TBI) and associated with worse neurologic outcomes longer hospitalization. However, the incidence causes of ARDS in isolated TBI have not been well studied. METHODS We performed a subgroup analysis 210 consecutive patients severe enrolled prospective observational cohort at Level 1 trauma center between 2005 2014. Subjects required endotracheal intubation had defined by head Abbreviated Injury Scale...
Abstract Background Studies quantifying SARS-CoV-2 have focused on upper respiratory tract or plasma viral RNA with inconsistent association clinical outcomes. The between antigen levels and outcomes has not been previously studied. Our aim was to investigate the relationship nucleocapsid (N-antigen) concentration both markers of host response Methods N-antigen concentrations were measured in first study sample (D0), collected within 72 h hospital admission, from 256 subjects admitted March...