Nelson Iván Agudelo Higuita
A5078064718- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Fungal Infections and Studies
- Travel-related health issues
- Mosquito-borne diseases and control
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- Malaria Research and Control
- Parasitic infections in humans and animals
- Antifungal resistance and susceptibility
- Congenital Anomalies and Fetal Surgery
- Insect symbiosis and bacterial influences
- Antibiotics Pharmacokinetics and Efficacy
- Viral Infections and Vectors
- Actinomycetales infections and treatment
- Chronic Lymphocytic Leukemia Research
- Antimicrobial Resistance in Staphylococcus
- Global Maternal and Child Health
- Parasitic Infections and Diagnostics
- Bacterial Identification and Susceptibility Testing
University of Oklahoma Health Sciences Center
2007-2025
OU Health
2015-2025
Honduras Foundation for Agricultural Research
2023-2024
University of Oklahoma
2023
The Ohio State University
2020
University of Oklahoma Medical Center
2013
Abstract Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated female sex distinctive comorbidities. During...
A patient with well-controlled type 2 diabetes mellitus developed a severe pulmonary infection secondary to Rhizopus spp. after receiving short courses of corticosteroids for respiratory tract infection. He recovered an aggressive surgical intervention and treatment isavuconazole. Patients on chronic corticosteroid therapy have higher risk mucormycosis, but there are much fewer reports mucormycosis occurring in patients only steroid therapy.
Better understanding of the association between characteristics patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management.
Abstract Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim understand the host immunologic and microbial features of COVID-19 in recipients by leveraging a prospective multicenter cohort 86 age- sex-matched with 172 non-transplant controls. find that higher nasal SARS-CoV-2 viral abundance impaired clearance, lower anti-spike IgG levels. In addition, exhibit...
Abstract The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the IgM N-glycosylation has not been studied viral infection. analysis from healthy controls hospitalized disease 2019 (COVID-19) patients reveals increased high-mannose sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific...
Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can reactivate during acute illnesses. Recent studies have suggested SARS-CoV-2 infection lead to reactivation of such as Epstein-Barr Virus (EBV) and cytomegalovirus (CMV), yet, the extent impact COVID-19 its effect on host immune system remain incompletely understood. Here we present a comprehensive multi-omic analysis all known chronically infecting 1,154 hospitalized patients, from...
Skin and soft tissue infections result from microbial invasion of the skin its supporting structures. Management is determined by severity location infection patient comorbidities. Infections can be classified as simple (uncomplicated) or complicated (necrotizing nonnecrotizing), suppurative nonsuppurative. Most community-acquired are caused methicillin-resistant Staphylococcus aureus beta-hemolytic streptococcus. Simple usually monomicrobial present with localized clinical findings. In...
Human population growth and development coupled with centuries of atmospheric colonization by the world's richest regions have now made evident a potentially irreversible disruption in restoration capacity planet's ecosystems. The production, utilization, consumption animal products has been closely intertwined to human biologic social evolution. This relationship is threatening health equilibrium ecosystem. Global food production responsible for 35% all greenhouse gas emissions (GHGE) use...
The post-acute sequelae of SARS-CoV-2 (PASC), also known as long COVID, remain a significant health issue that is incompletely understood. Predicting which acutely infected individuals will go on to develop COVID challenging due the lack established biomarkers, clear disease mechanisms, or well-defined sub-phenotypes. Machine learning (ML) models offer potential address this by leveraging clinical data enhance diagnostic precision. We utilized data, including antibody titers and viral load...
Following SARS-CoV-2 infection, ∼10-35% of COVID-19 patients experience long COVID (LC), in which often debilitating symptoms persist for at least three months. Elucidating the biologic underpinnings LC could identify therapeutic opportunities. We utilized machine learning methods on analytes and patient reported outcome surveys provided over 12 months after hospital discharge from >500 hospitalized IMPACC cohort to a multi-omics "recovery factor". participants who experienced had lower...
Human hookworm infection is caused by the nematodes Necator americanus , Ancylostoma duodenale and ceylanicum . Iron deficiency anemia hallmark of chronic, moderate-to-heavy-intensity infections, promoting a vicious poverty cycle. Overt severe acute life-threatening lower gastrointestinal hemorrhage an extremely rare manifestation infection, as well finding multiple attached to colonic mucosae. This presentation with hematochezia from colon in patient living human immunodeficiency virus...
CD16 is an activating Fc receptor on natural killer cells that mediates antibody-dependent cellular cytotoxicity (ADCC), a key mechanism in antiviral immunity. However, the role of NK cell-mediated ADCC SARS-CoV-2 infection remains unclear, particularly whether it limits viral spread and disease severity or contributes to immunopathogenesis COVID-19. We hypothesized high-affinity CD16AV176 polymorphism influences these outcomes. Using novel vitro reporter system, we demonstrated more potent...
Abstract Background Prior reports have suggested a possible increase in the frequency of invasive fungal infections (IFIs) with use Bruton tyrosine kinase inhibitor (BTKi) for treatment chronic lymphoid malignancies such as lymphocytic leukemia (CLL), but precise estimates are lacking. We aim to characterize prevalence IFIs among patients CLL, whom BTKi is now first-line recommended therapy. Methods queried TriNetX, global research network database, identify adult CLL using International...
Abstract Background Leprosy, also known as Hansen's disease, is a chronic infectious disease caused primarily by Mycobacterium leprae, endemic to tropical countries. In 2022, WHO registered 165,459 cases of leprosy. We lack more contemporary clinical descriptions and outcomes the disease. Understanding its characteristics essential for improving diagnosis, treatment, patient outcomes. aim describe manifestations associated with leprosy using "real-world" database. US Map proportion captured...
Abstract Background Last-minute travellers (LMTs) present challenges for health care providers because they may have insufficient time recommended vaccinations or pre-travel preparation. Our objective was to obtain a better understanding of LMTs in order help travel medicine develop improved strategies decrease the number and potentially reduce travel-related morbidity. Methods We defined as with departure date 7 days fewer from medical encounter. analysed characteristics preparation 12 494...