Jordan P. Metcalf
A5030911572- Influenza Virus Research Studies
- Bacillus and Francisella bacterial research
- interferon and immune responses
- Respiratory viral infections research
- Virus-based gene therapy research
- Inhalation and Respiratory Drug Delivery
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Marriage and Sexual Relationships
- Viral gastroenteritis research and epidemiology
- Microbial Inactivation Methods
- Viral Infections and Outbreaks Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Complement system in diseases
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Cytomegalovirus and herpesvirus research
- Bacteriophages and microbial interactions
OU Health
2011-2025
University of Oklahoma Health Sciences Center
2016-2025
Oklahoma City University
2025
Veterans Health Administration
2015-2024
Oklahoma State University
2024
Texas Center for Infectious Disease
2018-2022
Oklahoma City VA Medical Center
2021
Oklahoma City VA Health Care System
2016
Indiana University – Purdue University Indianapolis
2007-2013
Indiana University School of Medicine
2007-2013
Abstract Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated female sex distinctive comorbidities. During...
Better understanding of the association between characteristics patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management.
BACKGROUNDPatients hospitalized for COVID-19 exhibit diverse clinical outcomes, with outcomes some individuals diverging over time even though their initial disease severity appears similar to that of other patients. A systematic evaluation molecular and cellular profiles the full course can link immune programs coordination progression heterogeneity.METHODSWe performed deep immunophenotyping conducted longitudinal multiomics modeling, integrating 10 assays 1,152 Immunophenotyping Assessment...
IMPACC is a multicenter longitudinal study assessing clinical and immunologic manifestations of COVID-19 in hospitalized patients.
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in United States and primarily caused by cigarette smoking. Increased numbers mucus-producing secretory ("goblet") cells, defined as goblet cell metaplasia or hyperplasia (GCMH), contributes significantly to COPD pathophysiology. The objective this study was determine whether NOTCH signaling regulates differentiation response smoke. Primary human bronchial epithelial cells (HBECs) from nonsmokers smokers with...
Abstract The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the IgM N-glycosylation has not been studied viral infection. analysis from healthy controls hospitalized disease 2019 (COVID-19) patients reveals increased high-mannose sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific...
Adenovirus (AdV) is a common cause of respiratory illness in both children and adults. Respiratory symptoms can range from those the cold to severe pneumonia. Infection also significant disease immunocompromised among immunocompetent subjects close quarters. Fortunately, infection with AdV normal host generally mild. This one reason why its initial use as gene-therapy vector appeared be so promising. Unfortunately, innate adaptive responses virus have limited development vectors tool gene...
Cigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD) and predisposes subjects to severe respiratory tract infections. Epidemiological studies have shown that cigarette smokers are seven times more likely contract influenza infection than nonsmokers. The mechanisms underlying this increased susceptibility poorly characterized. Retinoic acid-inducible gene (RIG)-I believed play an important role in recognition of, response to, virus other RNA viruses. Our study...
Abstract The respiratory system is a complex network of many cell types, including subsets macrophages and dendritic cells that work together to maintain steady-state respiration. Owing limitations in acquiring from healthy human lung, these remain poorly characterized transcriptionally phenotypically. We set out systematically identify airways by developing schema isolating large numbers whole-lung bronchoalveolar lavage. Six phagocytic APC (HLA-DR+) were consistently observed. Aside...
Wnt/β-catenin signaling is an essential pathway in cell cycle control. Dysregulation of the during viral infection has been reported. In this study, we examined effect modulating influenza virus infection. The activation by Wnt3a increased mRNA and production vitro mouse lung epithelial E10 cells expresson genes vivo lungs mice infected with A/Puerto Rico/8/34. However, inhibition iCRT14 reduced titer gene expression human A549 replication primary alveolar different strains. Knockdown...
<h3>Importance</h3> Use of e-cigarettes (ECs) among youths has increased in recent years. e-Cigarette aerosol contains chemical constituents, such as diacetyl or benzaldehyde, which are known to affect the respiratory system. <h3>Objective</h3> To examine association between EC use and self-reported wheezing a cohort US adolescents. <h3>Design, Setting, Participants</h3> This study used data from waves 3 4 (October 19, 2015, January 3, 2018) Population Assessment Tobacco Health (PATH) study,...
Influenza is a significant cause of morbidity and mortality. The recent pandemic novel H1N1 influenza virus has stressed the importance search for effective treatments this disease. Essential oils from aromatic plants have been used wide variety applications, such as personal hygiene, therapeutic massage even medical practice. In paper, we investigate potential role an essential oil in antiviral activity.We studied commercial blend, On Guard™, evaluated its ability modulating virus, A/PR8/34...
The urgent need for effective treatments acute and chronic lung diseases underscores the significance of developing innovative preclinical human research tools. 2023 ATS Workshop on Precision Cut Lung Slices (PCLS) brought together 35 experts to discuss address role tissue-derived PCLS as a unique tool target drug discovery validation in pulmonary medicine. With increasing interest usage, along with advancements methods technology, there is growing consensus methodology readouts. current...
Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can reactivate during acute illnesses. Recent studies have suggested SARS-CoV-2 infection lead to reactivation of such as Epstein-Barr Virus (EBV) and cytomegalovirus (CMV), yet, the extent impact COVID-19 its effect on host immune system remain incompletely understood. Here we present a comprehensive multi-omic analysis all known chronically infecting 1,154 hospitalized patients, from...
We hypothesized that the peptidoglycan component of B. anthracis may play a critical role in morbidity and mortality associated with inhalation anthrax. To explore this issue, we purified bacterial cell wall studied response human peripheral blood cells. The was free non-covalently bound protein but contained complex set amino acids probably arising from stem peptide. polysaccharide removed by mild acid treatment, biological activity remained not polysaccharide. sensitive to lysozyme other...
During advanced stages of inhalation anthrax, Bacillus anthracis accumulates at high levels in the bloodstream infected host. This bacteremia leads to sepsis during late-stage anthrax; however, mechanisms through which B. anthracis-derived factors contribute pathology hosts are poorly defined. Peptidoglycan, a major component cell wall Gram-positive bacteria, can provoke symptoms animal models. We have previously shown that peptidoglycan induce production proinflammatory cytokines by cells...
Abstract Inhalation anthrax is often described as a toxin‐mediated disease. However, the toxaemia model does not account for high mortality of inhalation relative to other forms disease or pathology present in anthrax. Patients with consistently show extreme bacteraemia and, contrast animals challenged toxin, signs sepsis. Rather than toxaemia, we propose that death results from an overwhelming leads severe According our model, central role toxin permit vegetative bacteria escape immune...
Cigarette smoking (CS) is the main risk factor for development of chronic obstructive pulmonary disease (COPD) and most COPD exacerbations are caused by respiratory infections including influenza. Influenza more severe in smokers. The mechanism increased severity smokers likely multifactorial, but certainly includes changes immunologic host defenses. We investigated retinoic acid-inducible protein I (RIG-I) interferon (IFN) induction influenza A virus (IAV) human bronchial epithelial cells...