A5028941216- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Acute Lymphoblastic Leukemia research
- Clostridium difficile and Clostridium perfringens research
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
- Helicobacter pylori-related gastroenterology studies
- Health Systems, Economic Evaluations, Quality of Life
- Celiac Disease Research and Management
- Diverticular Disease and Complications
- Pancreatitis Pathology and Treatment
- Diagnosis and treatment of tuberculosis
- Liver Disease Diagnosis and Treatment
- Empathy and Medical Education
- Autoimmune and Inflammatory Disorders Research
- Mycobacterium research and diagnosis
- Liver Disease and Transplantation
- Reproductive System and Pregnancy
- Chronic Lymphocytic Leukemia Research
- Patient-Provider Communication in Healthcare
- Hepatitis B Virus Studies
Hospital Universitario Ramón y Cajal
2015-2024
Universidad de Alcalá
1999-2023
Instituto Ramón y Cajal de Investigación Sanitaria
2017-2023
Instituto Cajal
2004-2021
Pfizer (United States)
2021
Takeda (United States)
2021
AbbVie (United States)
2021
Creative Commons
2021
Crohn's and Colitis UK
2021
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2014-2019
Faecal microbiota transplantation (FMT) is an important therapeutic option for <i>Clostridium difficile</i> infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with alteration gut microbiota. Although health community assessing renewed interest and patients are becoming more aware, there technical logistical issues establishing such non-standardised treatment into clinical practice safety proper governance. In view this,...
Background The impact of pregnancy on the course IBD is still controversial. Aim To investigate and to search for factors with potential remission. Methods Pregnant women from 12 European countries were enrolled between January 2003 December 2006 compared at conception (1:1) nonpregnant women. Data disease prospectively collected each trimester during in postpartum (6 months) using a standardised questionnaire. Results A total 209 pregnant included: 92 Crohn's (CD; median age 31 years, range...
Objective Ciclosporin and infliximab have demonstrated short-term similar efficacy as second-line therapies in patients with acute severe UC (ASUC) refractory to intravenous steroids. The aim of this study was assess long-term outcome included a randomised trial comparing ciclosporin infliximab. Design Between 2007 2010, 115 steroid-refractory ASUC were 29 European centres receive or association azathioprine. Patients followed until death last news up January 2015. Colectomy-free survival...
Summary Background Pancreatitis is a potentially severe condition. Patients with inflammatory bowel disease (IBD) seem to be at increased risk for acute pancreatitis. Aim To describe the incidence, main causes and possible predictive factors of pancreatitis in disease. Methods Information was retrospectively extracted from clinical records patients followed IBD Units nine hospitals Madrid ( n = 5073). Results A total 82 episodes were diagnosed (cumulative 1.6%); 98% them mild. Recurrent...
Aliment Pharmacol Ther 2011; 34: 544–554 Summary Background Low thiopurine-methyl-transferase (TPMT) activity and high 6-thioguanine-nucleotide (6TGN) concentrations have been linked to therapeutic success in inflammatory bowel disease patients treated with thiopurines; however, this has not implemented clinical practice. Aim To identify a threshold value for TPMT or 6TGN concentrations, their capability predict treatment safety efficacy. Methods Prospective multicentre study including...
Postoperative recurrence of Crohn's disease [POR-CD] is almost certain if no prophylaxis administered. Evidence for optimal treatment lacking. Our aim was to compare the efficacy adalimumab [ADA] and azathioprine [AZA] in this setting. We performed a phase 3, 52-week, multicentre, randomised, superiority study [APPRECIA], which patients with ileocolonic resection were randomised either ADA 160-80-40 mg subcutaneously [SC] or AZA 2.5 mg/kg/day, both associated metronidazole. The primary...
Abstract Background Crohn’s disease (CD) is a chronic, immune-mediated inflammatory condition of the intestine, for which majority patients still needs to undergo surgical resection. Following most common intervention ileocolonic resection, vast suffers from recurrence CD in neoterminal ileum. Endoscopic lesions usually precede symptoms first months after resection and predict severity further course. No treatments have been approved recurrence-prevention CD. REPREVIO prospective...
As inflammatory bowel diseases [IBD] affect female patients almost exclusively during their reproductive age, issues related to fertility, fecundity, pregnancy, delivery, and lactation are of utmost importance. Lack education misconceptions regarding the effect disease and/or treatment on outcome may lead voluntary childlessness development unwanted cervical pathologies which impact tremendously patients' welfare quality life. The aims this study were assess perspectives IBD pregnancy its...
Autologous haematopoietic stem cell transplantation [AHSCT] is a therapeutic option for patients with severe, treatment-refractory Crohn's disease [CD]. The evidence base AHSCT CD limited, one randomised trial [ASTIC] suggesting benefit. aim of this study was to evaluate safety and efficacy undergoing in Europe, outside the ASTIC trial. We identified 99 European Society Blood Marrow Transplantation [EBMT] registry, who were eligible inclusion. Transplant clinical outcomes obtained 82 from 19...
Background. Methotrexate is an effective treatment for inflammatory bowel disease (IBD). However, long-term treatments have been associated with the development of liver fibrosis. FibroScan® a noninvasive, safe, and technique to evaluate Aim. To presence significant fibrosis by transient elastography (FibroScan®) in IBD patients treated methotrexate. Methods. Cross-sectional study including methotrexate from different hospitals. Clinical analytical data, duration treatment, cumulative dose...
The use of Janus kinase (JAK) inhibitors is a new approach in the therapy inflammatory diseases with immune base. Tofacitinib one these targeting JAK1 and JAK3, its efficacy has been demonstrated treatment moderate to severe ulcerative colitis (UC). It small synthetic molecule administered orally, fast bioavailability elimination rate, predictable pharmacokinetics lack immunogenicity, which are convenient characteristics for both safety. This article reviews pharmacological tofacitinib...
The aims of this study were to evaluate the frequency entero-urinary fistulas in a cohort Crohn's disease (CD) patients and analyse outcomes medical surgical therapy. This multicentre retrospective included all CD with diagnosed by presence clinical symptoms confirmed at surgery or radiological endoscopic techniques. We evaluated defined remission as absence confirmation fistula closure. Cox regression analysis was performed factors predictive achieving without need for surgery. Of 6081...
Summary Background : The efficacy of azathioprine in the management steroid‐dependent ulcerative colitis is taken for granted. However, study populations frequently include together and refractory patients. Aim To assess safety thiopurinic immunomodulators strictly defined colitis. Methods Survey 34 patients with colitis, treated according to protocol. Therapeutical success: glucocorticoid withdrawal within 12 months, without steroid requirements during another year. Results Mean age was...
infliximab is a monoclonal antiTNF-ct antibody that has repeatedly shown to be effective in the management of Crohn's disease. However, data are scarce about its efficacy ulcerative colitis.to describe joint experience three Spanish hospitals use patients with active refractory colitis.we present seven cases colitis (6 chronic disease despite immunosuppressive therapy, and one acute steroid-refractory colitis) treated 5 mg/kg body weight. Clinical response was evaluated by means Activity...