A5025482453- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Intestinal Malrotation and Obstruction Disorders
- Adolescent and Pediatric Healthcare
- Helicobacter pylori-related gastroenterology studies
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Celiac Disease Research and Management
- Gastroesophageal reflux and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Clinical Nutrition and Gastroenterology
- Gut microbiota and health
- Pregnancy and Medication Impact
- Gastrointestinal motility and disorders
- Pancreatitis Pathology and Treatment
- Viral gastroenteritis research and epidemiology
- Autoimmune and Inflammatory Disorders
- Infant Nutrition and Health
- Esophageal and GI Pathology
- Acute Lymphoblastic Leukemia research
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2011-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2025
University of Milan
2025
Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau
2021
ADIR Association
2021
Ministero della Salute
2021
Hvidovre Hospital
2020
Tel Aviv University
2017
Sheba Medical Center
2017
Faecal microbiota transplantation (FMT) is an important therapeutic option for <i>Clostridium difficile</i> infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with alteration gut microbiota. Although health community assessing renewed interest and patients are becoming more aware, there technical logistical issues establishing such non-standardised treatment into clinical practice safety proper governance. In view this,...
We aimed to provide an evidence-supported update of the ECCO-ESPGHAN guideline on medical management paediatric Crohn's disease [CD].
The contemporary management of ambulatory ulcerative colitis (UC) continues to be challenging with ∼20% children needing a colectomy within childhood years. We thus aimed standardize daily treatment pediatric UC and inflammatory bowel diseases (IBD)-unclassified through detailed recommendations practice points.These guidelines are joint effort the European Crohn's Colitis Organization (ECCO) Paediatric IBD Porto group Society Gastroenterology, Hepatology Nutrition (ESPGHAN). An extensive...
A new caspase-independent mode of programmed cell death, termed necroptosis, has recently been identified. Altered expression molecules involved in the necroptosis pathway shown to trigger intestinal inflammation. The initiation is principally mediated by release receptor interacting protein 3 (RIP3) from suppression caspase-8. Furthermore, it suggested that mixed lineage kinase domain-like (MLKL) factor an target RIP3 active necroptosis. This study aims at investigating occurrence children...
The infant gut microbiome plays a key role in the healthy development of human organism and appears to be influenced by dietary practices through multiple pathways. First, maternal diet during pregnancy nutrition significantly influence microbiota. Moreover, breastfeeding fosters proliferation beneficial bacteria, while formula feeding increases microbial diversity. timing introducing solid foods also influences microbiota composition. In preterm infants is factors, including time since...
A growing body of evidence supports the need for detailed attention to nutrition and diet in children with inflammatory bowel disease (IBD). We aimed define steps instituting dietary or nutritional management light current offer a useful practical guide physicians dieticians involved care pediatric IBD patients.A group 20 experts participated an iterative consensus process including 2 face-to-face meetings, following open call Nutrition Committee European Society Pediatric Gastroenterology,...
Early-onset (EO) pediatric inflammatory bowel diseases (IBD) seem to be more extensive than those with a later onset. To test this hypothesis, we examined the phenotype and disease course of patients IBD diagnosis at 0 5 years, compared ranges 6 11 12 18 years.Anatomic locations behaviors were assessed according Paris classification in 506 consecutive patients: 224 Crohn's disease, 245 ulcerative colitis, 37 IBD-unclassified.Eleven percent range 39% 50% years. Ulcerative colitis was most...
With the current coronavirus disease 2019 (COVID-19) pandemic, concerns have been raised about risk to children with inflammatory bowel diseases (IBD). We aimed collate global experience and provide provisional guidance for managing paediatric IBD (PIBD) in era of COVID-19.An electronic reporting system infected SARS-CoV-2 has circulated among 102 PIBD centres affiliated Porto Interest-group ESPGHAN. A survey completed by major China South-Korea explore management during pandemic. third...
Acute severe colitis (ASC) is one of the few emergencies in pediatric gastroenterology. Tight monitoring and timely medical surgical interventions may improve outcomes minimize morbidity mortality. We aimed to standardize daily treatment ASC children through detailed recommendations practice points which are based on a systematic review literature consensus experts.These guidelines joint effort European Crohn's Colitis Organization (ECCO) Society Paediatric Gastroenterology, Hepatology...
The extent and factors associated with risk of diagnostic delay in pediatric celiac disease (CD) are poorly understood.
Abstract Background Tasty&HealthyTM (T&H) is a whole food diet aimed at alleviating inflammation in Crohn’s disease (CD). It excludes processed food, gluten, red meat, and dairy (except for plain yogurt), but does not include mandatory ingredients or partial enteral nutrition with formula as the CD Exclusion Diet. In this RCT we evaluated T&H an intervention persistent subclinical compared continuing habitual diet. (NCT#04239248; TASTI-E). Methods Patients CD, aged 6-40 years,...
Adherent-invasive Escherichia coli (AIEC) have been implicated in the ethiopathogenesis of Crohn’s disease (CD). In this study, we analyzed a collection intestinal mucosa-associated E. isolates, presenting AIEC phenotypes, isolated from biopsies CD pediatric patients and non-inflammatory bowel diseases (IBD) controls, order to investigate their genetic phenotypic pathogenic features. A total 616 isolates four non-IBD controls were collected individually analyzed. For identification, adherent...
This European Crohn's and Colitis Organisation [ECCO] topical review focuses on the transition of adolescents with inflammatory bowel disease [IBD] from child-centred to adult-oriented care. The aim was provide evidence-supported, expert consensus for health professionals taking part in transition.An online survey determined areas importance involved IBD. Thereafter an panel nine paediatric five adult gastroenterologists formed identify critical elements programme, prepare core messages...
Journal Article Presenting features and disease course of pediatric ulcerative colitis Get access Marina Aloi, Aloi Pediatric Gastroenterology Liver Unit, Sapienza University Rome, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Giulia D'Arcangelo, D'Arcangelo Fabrizio Pofi, Pofi Francesca Vassallo, Vassallo Valentina Rizzo, Rizzo Federica Nuti, Nuti Giovanni Di Nardo, Nardo Maria Pierdomenico, Pierdomenico Franca Viola, Viola Salvatore Cucchiara ⁎...
An expanding number of monogenic defects have been identified as causative severe forms very early-onset inflammatory bowel diseases [VEO-IBD]. The present study aimed at defining how next-generation sequencing [NGS] methods can be used to improve identification known molecular diagnosis and adapt treatment.A total 207 children were recruited in 45 paediatric centres through an international collaborative network [ESPGHAN GENIUS working group] with a clinical presentation VEO-IBD [n = 185]...
Large evidence supports the role of microRNAs as new important inflammatory mediators by regulating both adaptive and innate immunity. In present study, we speculated that miR-320 controls NOD2 (nucleotide-binding oligomerization domain) expression, because it contains multiple binding sites in 3′-untranslated region gene. NOD2, first gene associated to increased susceptibility Crohn's disease, is a cytosolic receptor senses wall peptides bacteria promotes their clearance through initiation...
The combination of the severity pediatric-onset inflammatory bowel disease (IBD) phenotypes and need for intense medical treatment may increase risk malignancy mortality, but evidence regarding extent problem is scarce. Therefore, Porto Pediatric IBD working group ESPGHAN conducted a multinational-based survey cancer mortality in pediatric IBD.A among gastroenterologists 20 European countries Israel on and/or patient population with was undertaken. One representative from each country...
Noninvasive biomarkers of high- and low-grade intestinal inflammation mucosal healing (MH) in patients with inflammatory bowel disease are currently lacking. We have recently shown that fecal high mobility group box 1 (HMGB1) protein is a novel biomarker gut inflammation. aimed at investigating mouse model if HMGB1 was able to foresee both clinically evident subclinical its normalization indicated MH. also confirming the results Crohn's (CD) ulcerative colitis.C57BL6/J mice were treated...
Second-generation colon capsule endoscopy (CCE-2) may overcome the invasiveness of colonoscopy in evaluation mucosal inflammation, especially pediatric ulcerative colitis. The aim this pilot study was to determine diagnostic accuracy CCE-2 evaluating disease activity, using as a gold standard. Disease extent, tolerability, interobserver agreement, and safety were also evaluated.A total 30 consecutive patients with colitis prospectively enrolled (mean age 14.1 ± 3.2 years). Patients underwent...