A5075838981- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Hematopoietic Stem Cell Transplantation
- Gastrointestinal motility and disorders
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Parasitic Infections and Diagnostics
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Neutropenia and Cancer Infections
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Nosocomial Infections in ICU
- Dietary Effects on Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gastrointestinal disorders and treatments
- HIV/AIDS oral health manifestations
- Oral microbiology and periodontitis research
- Surgical Simulation and Training
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Vasculitis and related conditions
Amsterdam University Medical Centers
2019-2024
University of Amsterdam
2013-2024
Amsterdam UMC Location University of Amsterdam
2014-2020
Spaarne Gasthuis
2020
Fred Hutch Cancer Center
2019
Leiden University Medical Center
2019
Academic Center for Dentistry Amsterdam
1994
Faecal microbiota transplantation (FMT) is an important therapeutic option for <i>Clostridium difficile</i> infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with alteration gut microbiota. Although health community assessing renewed interest and patients are becoming more aware, there technical logistical issues establishing such non-standardised treatment into clinical practice safety proper governance. In view this,...
Bariatric surgery improves glucose metabolism. Recent data suggest that faecal microbiota transplantation (FMT) using faeces from postbariatric diet-induced obese mice in germ-free metabolism and intestinal homeostasis. We here investigated whether allogenic FMT post-Roux-en-Y gastric bypass donors (RYGB-D) compared with metabolic syndrome (METS-D) has short-term effects on metabolism, transit time adipose tissue inflammation treatment-naïve, obese, insulin-resistant male subjects.Subjects...
Objective Type 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell destruction. A gut microbiota–immunological interplay involved in the pathophysiology of T1D. We studied microbiota-mediated effects on disease progression patients with type using faecal microbiota transplantation (FMT). Design Patients recent-onset (<6 weeks) T1D (18–30 years age) were randomised into two groups to receive three autologous or allogenic (healthy donor) FMTs over a period 4 months. Our...
Objective Environmental factors driving the development of type 1 diabetes (T1D) are still largely unknown. Both animal and human studies have shown an association between altered fecal microbiota composition, impaired production short-chain fatty acids (SCFA) T1D onset. However, observational evidence on SCFA oral in adults with longstanding vs healthy controls (HC) is lacking. Research design methods We included 53 patients without complications or medication 50 HC matched for age, sex...
Donor fecal microbiota transplantation restores gut microbial diversity and reduces graft-versus-host disease in hematopoietic cell transplant recipients.
Infections with multidrug-resistant microorganisms are associated increased hospitalization, medication costs and mortality. Based on our fecal microbiota transplantation (FMT) experience for Clostridium difficile infection, we treated 15 patients carrying ESBL-producing Enterobacteriaceae (ESBL-EB) FMT. Seven underwent a second FMT after 4 weeks when ESBL-EB remained, amounting to total number of 22 transplants. The objective was decolonization ESBL-EB.Three out fifteen (20%) were...
Fecal microbiota transfer (FMT) is an effective treatment for recurrent Clostridium difficile infection (CDI), but data on procedure-related complications and long-term outcome are scarce.All patients treated with FMT CDI at the Academic Medical Center between July 2010 January 2016 were included. was performed according to FECAL trial protocol: administration of fresh donor feces (related or unrelated donor) through a duodenal tube after pre-treatment vancomycin bowel lavage. We collected...
Ulcerative colitis (UC) is thought to originate from a disbalance in the interplay between gut microbiota and innate adaptive immune system. Apart bacterial microbiota, there might be other organisms, such as parasites or viruses, that could play role aetiology of UC. The primary objective this study was compare prevalence Blastocystis sp. cohort patients with active UC healthy controls. We studied confirmed by endoscopy included randomised prospective trial on faecal transplantation for A...
The subgingival microflora in a patient with localized juvenile periodontitis was studied. Of the 97 sites investigated, 28 (29%) showed attachment loss. A correlation found between number of Actinobacillus actinomycetemcomitans cells and clinical level probing pocket depth. test sites, 70 (73%) were positive for A. actinomycetemcomitans. total isolated from this patient, more than 99% at loss, < 1% being present without mean percentage 21.2% loss 0.45% distribution Porphyromonas gingivalis...
Insulin resistance develops prior to the onset of overt type 2 diabetes, making its early detection vital. Direct accurate evaluation is currently only possible with complex examinations like stable isotope-based hyperinsulinemic euglycemic clamp (HIEC). Metabolomic profiling enables thousands plasma metabolites, providing a tool identify novel biomarkers in human obesity.Liquid chromatography mass spectrometry-based untargeted metabolomics was applied 60 participants obesity large range...
Context/Objective: In order to better understand which metabolic differences are related insulin resistance in syndrome (MetSyn), we used hyperinsulinemic–euglycemic (HE) clamps individuals with MetSyn and peripheral circulating biomarkers. Design/Methods: this cross-sectional study, HE-clamps were performed treatment-naive men (n = 97) MetSyn. Subjects defined as insulin-resistant based on the rate of disappearance (Rd). Machine learning models conventional statistics identify biomarkers...
IntroductionEnteric dysbiosis has a negative influence on the outcome of allogeneic hematopoietic stem cell transplantation (HSCT) recipients. The presence an imbalanced microbiome, marked by decreased gut flora diversity and intestinal pathobiont domination, is associated with increased risk to develop graft-versus-host disease (GvHD).ObjectivesThis prospective, single-arm pilot study tested if donor fecal microbiota (FMT) safe effective treat GvHD.MethodsFifteen patients steroid-refractory...
Plasma metabolites affect a range of metabolic functions in humans, including insulin sensitivity (IS). A subset these plasma is modified by the gut microbiota. To identify potential microbial–metabolite pathways involved IS, we investigated link between metabolites, microbiota composition, and using gold-standard for peripheral hepatic IS measurement group participants with syndrome (MetSyn). In cross-sectional study 115 MetSyn participants, fasting samples were collected untargeted...
Metabolic syndrome (MetSyn) is an important risk factor for type 2 diabetes and cardiovascular diseases (CVD). This study aimed to find distinct plasma metabolite profiles between insulin-resistant non-insulin resistant subjects with MetSyn evaluate if are related CVD lipid fluxes. In a cross-sectional study, untargeted metabolomics of treatment-naive males (n = 132) were analyzed together clinical parameters. subset participants, was calculated using the Framingham score 111), lipolysis 39)...
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare heterogeneous disease in which treatment must be initiated early to prevent irreversible organ damage and death. There are several diseases that can mimic AAV, even the presence of positive ANCA serology and/or histological evidence vasculitis, as demonstrated this case series. We reflect on diagnostic approach patients with AAV provide an overview AAV-mimicking considered atypical presentation or course.
Here we present the case of a 28-year-old man with X-linked immunodeficiency magnesium defect, Epstein-Barr virus (EBV) infection and neoplasia (XMEN) disease. He presented immune thrombocytopenia within 1 year after successful autologous hematopoietic stem cell transplantation for recurrent EBV-associated classical Hodgkin lymphoma (CHL). The combination EBV- associated malignancy, autoimmunity, airway infections at young age bronchiectasis, prompted immunological investigation an inborn...
Fecal Microbiota Transplantation (FMT) has emerged as a potential modality for mitigating microbiome-associated diseases. Despite this potential, the precise causal pathways by which specific gut microbiota strains induce remission remain inadequately elucidated. In study, we aimed to discern impact of engraftment donor-infused on alterations in plasma metabolites, subsequently contributing amelioration clinical parameters involved subjects with metabolic syndrome (MetSyn) receiving an FMT....
gastrointestinal growth conditions.This study indicated also that bacterial virulence factors act in concert to elicit their pathogenic potential whereas the host-immune system evolved strong mechanisms detect and target bacteria regardless of surface arming.