A5101757507- Gut microbiota and health
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Probiotics and Fermented Foods
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Urinary Tract Infections Management
- Viral gastroenteritis research and epidemiology
- Dermatology and Skin Diseases
- Enterobacteriaceae and Cronobacter Research
- Infant Nutrition and Health
- Respiratory and Cough-Related Research
- Essential Oils and Antimicrobial Activity
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Pathogenesis and Treatment of Hiccups
- Antimicrobial Peptides and Activities
- Gastroesophageal reflux and treatments
- Nasal Surgery and Airway Studies
- Respiratory viral infections research
Sapienza University of Rome
2016-2025
Background: Gastrointestinal disorders are frequent in COVID-19 and SARS-CoV-2 has been hypothesized to impact on host microbial flora gut inflammation, infecting intestinal epithelial cells. Since there currently no coded therapies or guidelines for treatment of COVID-19, this study aimed evaluate the possible role a specific oral bacteriotherapy as complementary therapeutic strategy avoid progression COVID-19. Methods: We provide report 70 patients positive hospitalized between March 9th...
Background: Mounting evidence suggests SARS-CoV-2 may impact on host microbiota and gut inflammation, infecting intestinal epithelial cells. This possible link its implications can be investigated by observing the effects of modulation microbial flora in patients with COVID-19. The aim this study was to compare rate mortality, need ICU hospitalization length severe COVID-19 pneumonia who received best available therapy (BAT) vs. treated BAT supplemented oral bacteriotherapy. Methods:...
Adherent-invasive Escherichia coli (AIEC) have been implicated in the ethiopathogenesis of Crohn’s disease (CD). In this study, we analyzed a collection intestinal mucosa-associated E. isolates, presenting AIEC phenotypes, isolated from biopsies CD pediatric patients and non-inflammatory bowel diseases (IBD) controls, order to investigate their genetic phenotypic pathogenic features. A total 616 isolates four non-IBD controls were collected individually analyzed. For identification, adherent...
In the treatment of upper GI endoscopy-negative patients with heartburn and epigastric pain or burning, antacids, antireflux agents, mucosal protective agents are widely used, alone as add-on treatment, to increase response proton-pump inhibitors, which not indicated in infancy pregnancy account for significant cost expenditure.
Background Atopic dermatitis (AD) is a chronic inflammatory skin condition whose pathogenesis involves genetic predisposition, epidermal barrier dysfunction, alterations in the immune responses and microbial dysbiosis. Clinical studies have shown link between Staphylococcus aureus of AD, although origins diversity S. colonizing patients with AD poorly understood. The aim study was to investigate if specific clones might be associated disease. Methods WGS analyses were performed on 38...
Allergic rhinitis (AR) and adenoid hypertrophy (AH) are, in children, the main cause of partial or complete upper airway obstruction reduction airflow. However, limited data exist about impact increased resistance to airflow, on nasal microbial composition children with AR end AH. as well (AH), represent extremely common pathologies this population. Their known inflammatory is amplified when both coexist. In our study, microbiota anterior nares 75 pediatric subjects AR, AH conditions, was...
Respiratory Syncytial Virus (RSV) is the leading cause of bronchiolitis, and severity may be influenced by bacterial ecosystem. Our aim was to analyze nasal microbiota from 48 infants affected bronchiolitis RSV virus 28 with but negative for virus. Results showed a significantly lower biodiversity in RSV-positive group respect RSV-negative group, specific microbial profile associated different that observed significant modifications relative abundance taxa as well RSV-A group. Furthermore,...
Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. Modifications of gut microbiota seem to be associated with the disease, but impact on therapies' outcome remains unclear. A role T cells in RA pathogenesis has been addressed, particularly Th17/Treg balance. Our study aimed evaluate early (ERA) patients compared control group, fecal composition, short-chain fatty acids concentrations, and levels circulating their own cytokines, before after 3 months standard treatment...
Long COVID refers to patients with symptoms as fatigue, "brain fog," pain, suggesting the chronic involvement of central nervous system (CNS) in COVID-19. The supplementation probiotic (OB) would have a positive effect on metabolic homeostasis, negatively impacting occurrence related CNS after hospital discharge. On total 58 hospitalized for COVID-19, 24 (41.4%) received OB during hospitalization (OB+) while 34 (58.6%) taken only standard treatment (OB-). Serum metabolomic profiling has been...
Adherent/invasive Escherichia coli (AIEC) strains have recently been receiving increased attention because they are more prevalent and persistent in the intestine of Crohn's disease (CD) patients than healthy subjects. Since AIEC show a high percentage similarity to extraintestinal pathogenic E. (ExPEC), neonatal meningitis-associated (NMEC), uropathogenic (UPEC) strains, here we compared strain LF82 with UPEC isolate (strain EC73) assess whether would be able infect prostate cells as an...
Allergic rhinitis (AR) is one of the most common allergic diseases affecting children. Objective assessment nasal obstruction possible through active anterior rhinomanometry (AAR). Several factors, such as passive smoke exposure (PSE), are triggers for worsening and chronic inflammation. PSE affects bacterial eubiosis in upper respiratory tract. This study evaluates influence cotinine levels on both local microbiome composition children with AR.Fifty patients (aged between 6 16 years) AR...
Satureja montana essential oil (SEO) presents a wide range of biological activities due to its high content active phytochemicals. In order improve the oil’s (EO) properties, in water nanoemulsions (NEs) composed SEO and Tween-80 were prepared, characterized, their antimicrobial antibiofilm properties assayed against Escherichia coli strains isolated from healthy chicken. Since surfactant composition can strongly influence NE features application field, ternary phase diagram was constructed...
Background: We previously reported that severe COVID-19 patients had higher chances of survival and a reduced risk developing respiratory failure when administered with the probiotic formulation SLAB51. This study aimed to investigate further bacteriotherapy mechanisms how early they are activated. Methods: performed an analysis on blood oxygenation parameters collected in sixty-nine requiring non-invasive oxygen therapy presenting CT lung involvement ≥50%. Twenty-nine received...
Several studies have shown fluctuations in the maternal microbiota at various body sites (gut, oral cavity, and vagina). The skin plays an important role our health, but on changes during pregnancy are limited. Quantitative qualitative variations pregnant woman could indeed play roles modifying immune inflammatory responses of host. These alterations induce disorders affecting individual's dermal properties, potentially predict infant disorder unborn. present study aimed to characterize...
Abstract Urinary tract infections (UTIs) are among the most common bacterial in humans. Although a number of bacteria can cause UTIs, cases due to infection by uropathogenic Escherichia coli (UPEC). UPEC genetically heterogeneous group that exhibit several virulence factors associated with colonization and persistence urinary tract. Caenorhabditis elegans is tiny, free‐living nematode found worldwide. Because many biological pathways conserved C. humans, has been increasingly used as model...
The chemopreventive potential of Resveratrol (RV) against bladder cancer and its mechanism action have been widely demonstrated. physicochemical properties RV, particularly high reactivity low solubility in aqueous phase, limiting factors for bioavailability vivo efficacy. In order to overcome these limitations, inclusion drug delivery systems needs be taken into account. particular, oil-in-water (O/W) nanoemulsions (NEs) considered ideal candidates RV encapsulation. Since surfactant oil...