A5036303158- Wound Healing and Treatments
- Inflammatory mediators and NSAID effects
- Skin Protection and Aging
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory Bowel Disease
- Adenosine and Purinergic Signaling
- Collagen: Extraction and Characterization
- Digestive system and related health
- Dermatology and Skin Diseases
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Dermatologic Treatments and Research
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Polysaccharides and Plant Cell Walls
- Bee Products Chemical Analysis
University of L'Aquila
2022-2025
Glioblastoma (GBM) is characterized by an immunosuppressive tumor microenvironment (TME) strictly associated with therapy resistance. Cyclooxygenase-2 (COX-2) fuels GBM proliferation, stemness, and chemoresistance. We previously reported that COX-2 upregulation induced temozolomide (TMZ) supported Also, transfer extracellular vesicles released T98G promoted M2 polarization in macrophages, whereas inhibition counteracted these effects. Here, we investigated the role stemness potential...
Abstract Background and Aims The renin-angiotensin system is known to modulate fibrosis, which a common complication of ileal Crohn’s disease. We tested the efficacy losartan, an angiotensin receptor blocker, treat intestinal fibrosis in relevant pre-clinical models Crohn’s-like Methods Effector molecules were mined large publicly-available RNA-Seq dataset biopsies from patients healthy individuals, presence associated proteins confirmed by immunohistochemistry full-thickness tissues....
TMZ-resistance remains a main limitation in glioblastoma (GBM) treatment. TMZ is an alkylating agent whose cytotoxicity modulated by O6-methylguanine-DNA methyltransferase (MGMT), expression determined MGMT gene promoter methylation status. The inflammatory marker COX-2 has been implicated GBM tumorigenesis, progression, and stemness. inhibitors are considered add-on treatment due to their ability increase TMZ-sensitivity. We investigated the effect of on cell lines showing different levels...
Hypoxia-inducible factor-1α (HIF-1α), a central player in maintaining gut-microbiota homeostasis, plays pivotal role inducing adaptive mechanisms to hypoxia and is negatively regulated by prolyl hydroxylase 2 (PHD2). HIF-1α stabilized through PI3K/AKT signaling regardless of oxygen levels. Considering the crucial HIF pathway intestinal mucosal physiology its relationships with gut microbiota, this study aimed evaluate ability lysate from multi-strain probiotic formulation SLAB51 affect model...
Abnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since the current therapeutic strategies revealed unsatisfactory, investigation of alternative approaches such as those based on use specific probiotic strains could provide promising options. In this study, we aimed to evaluate whether lysate from S. thermophilus antagonize fibrogenic effects TGF-β1 normal human fibroblasts (NHDF).NHDF were exposed establish a fibrotic...
Skin aging is a dynamic process that determines structural alterations in ECM and reduction dermal fibroblasts. The recent availability on the market of an innovative polycomponent formulation (KARISMA Rh Collagen® FACE, K) containing noncrosslinked high-molecular-weight hyaluronic acid (HMW-HA), human recombinant polypeptide collagen-1 alpha chain, carboxymethyl cellulose (CMC), attracted our scientific interest evaluating its biomolecular effects adult aged After treatment with increasing...
Temozolomide (TMZ) resistance is frequent in patients with glioblastoma (GBM), a tumor characterized by marked inflammatory microenvironment. Recently, we reported that cyclooxygenase-2 (COX-2) upregulated TMZ-resistant GBM cells treated high TMZ concentrations. Moreover, COX-2 activity inhibition significantly counteracted TMZ-resistance of cells. Extracellular vesicles (EV) are considered crucial mediators orchestrating drug modulating the microenvironment (TME) and affecting surrounding...
The mechanism underlying intestinal fibrosis, the main complication of inflammatory bowel disease (IBD), is not yet fully understood, and there no therapy to prevent or reverse fibrosis. We evaluated, in vitro cellular models, ability different classes drugs currently used IBD counteract two pivotal processes differentiation fibroblasts activated myofibroblasts using CCD-18Co cells, epithelial-to-mesenchymal transition (EMT) epithelial cells Caco-2 (IEC), both being induced by transforming...