A5079992777- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal pain and rehabilitation
- Systemic Lupus Erythematosus Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Diversity and Career in Medicine
- Exercise and Physiological Responses
- Autoimmune and Inflammatory Disorders Research
- Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Platelet Disorders and Treatments
- Psychosomatic Disorders and Their Treatments
- Autophagy in Disease and Therapy
- Heart Rate Variability and Autonomic Control
- Salivary Gland Disorders and Functions
- Inflammatory mediators and NSAID effects
- Medical and Biological Sciences
- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal Disorders and Rehabilitation
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 and Mental Health
- Vitamin D Research Studies
- Myofascial pain diagnosis and treatment
- Pain Management and Treatment
Sapienza University of Rome
2015-2024
Policlinico Umberto I
2007-2024
Center for Rheumatology
2021
Società Italiana di Reumatologia
2013
This study was performed to assess the utility of anti-cyclic citrullinated peptide (anti-CCP) antibodies in distinguishing between patients with rheumatoid arthritis (RA) and polyarticular involvement associated chronic hepatitis C virus (HCV) infection. Serum anti-CCP factor (RF) were evaluated 30 RA, 8 HCV infection articular 31 without any joint involvement. In addition, we retrospectively analysed sera collected at time first visit 10 originally presenting symmetric polyarthritis...
Autophagy may represent a functional processing event that creates substrate for autoreactivity. In particular, autophagy play role in the pathogenesis of RA, since is key cellular involved generation citrullinated peptides, with consequent breakage tolerance. Thus, be common feature several situations (including smoking, joint injury and infection) drive adaptive responses to self-proteins. The aim this study was analysis, vitro, peptides and, vivo, relationship between production anti-CCP...
Endothelial dysfunction has been detected in RA patients and seems to be reversed by control of inflammation. Low circulating endothelial progenitor cells (EPCs) have described many conditions associated with increased cardiovascular risk, including RA. The aim this study was investigate the effect inhibition TNF on EPCs patients. Seventeen moderate-severe 12 sex age-matched controls were evaluated. biomarkers tested at baseline after 3 months. identified from peripheral blood mononuclear...
This in-depth review of fibromyalgia (FM), which is a complex condition characterised by chronic pain, fatigue, sleep disturbances, and spectrum diagnostically therapeutically challenging symptoms, underlines the need for comprehensive integrated approach that also takes into account psychological factors affecting patient responses. We focus on substantial impact environmental (climatic variations, air pollution, electromagnetic field exposure, physical emotional traumas, dietary patterns,...
Vitamin D displays immunomodulatory activities and has been proposed as a potential player in the pathogenesis of rheumatoid arthritis (RA). A negative association between serum 25(OH) vitamin levels RA activity was demonstrated but longitudinal studies investigating role predicting response to treatment are lacking. Therefore, this study designed test hypothesis an at diagnosis disease evaluated by clinimetric, laboratory ultrasound (US) parameters detect prevalence remission after 12...
Fibromyalgia (FM) diagnosis follows the American College of Rheumatology (ACR) criteria, based on clinical evaluation and written questionnaires without any objective diagnostic tool. The lack specific biomarkers is a tragic aspect for FM chronic pain diseases in general. Interestingly, endogenous opioid system close to immune one because expression receptors lymphocytes membrane. Here we analyzed role Mu receptor B as biomarker osteoarthritis (OA) patients. We enrolled three groups females:...
Objectives . Impaired endothelial function represents the early stage of atherosclerosis, which is typically associated with systemic inflammatory diseases like rheumatoid arthritis (RA). As modulators nitric oxide synthase expression, asymmetric-dimethylarginine (ADMA) and apelin might be measured in blood RA patients to detect atherosclerotic changes. We conducted a prospective, case-control study investigate serum ADMA profiles early-stage (ERA) before after disease-modifying...
Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. Modifications of gut microbiota seem to be associated with the disease, but impact on therapies' outcome remains unclear. A role T cells in RA pathogenesis has been addressed, particularly Th17/Treg balance. Our study aimed evaluate early (ERA) patients compared control group, fecal composition, short-chain fatty acids concentrations, and levels circulating their own cytokines, before after 3 months standard treatment...
OBJECTIVES: Fibromyalgia (FM) is a common rheumatic disorder characterized by chronic, widespread pain associated with several not painful symptoms. The contribution of gender to the manifestation disease may influence higher prevalence FM among women. In spite this, how patients' influences clinical still well understood. frequent association neuropsychiatric symptoms raised attention on role neurotrophins, including brain-derived neurotrophic factor (BDNF) as potential biomarkers...