A5067659349- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Pelvic floor disorders treatments
- Congenital gastrointestinal and neural anomalies
- Diverticular Disease and Complications
- Anorectal Disease Treatments and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Bariatric Surgery and Outcomes
- Child Nutrition and Feeding Issues
- Pathogenesis and Treatment of Hiccups
- Dysphagia Assessment and Management
- Colorectal Cancer Surgical Treatments
- Inflammatory Bowel Disease
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Infant Health and Development
- Gut microbiota and health
- Autoimmune and Inflammatory Disorders
- Restless Legs Syndrome Research
- Neuropeptides and Animal Physiology
- Intestinal Malrotation and Obstruction Disorders
- Parathyroid Disorders and Treatments
Sapienza University of Rome
2015-2025
Policlinico Umberto I
2008-2022
Fondazione Santa Lucia
1997
Istituti di Ricovero e Cura a Carattere Scientifico
1995
Medica (Italy)
1989
Istituto di Sessuologia Clinica
1989
Ospedale Vincenzo Cervello
1987
Ospedale San Filippo Neri
1987
In the treatment of upper GI endoscopy-negative patients with heartburn and epigastric pain or burning, antacids, antireflux agents, mucosal protective agents are widely used, alone as add-on treatment, to increase response proton-pump inhibitors, which not indicated in infancy pregnancy account for significant cost expenditure.
This study was designed to investigate anorectal function in Parkinson's disease and multiple system atrophy (MSA). After a standardized interview, 17 patients with (PD) 16 (MSA) underwent manometry continuously perfused multi-lumen catheter, located record pressures from the anal canal, balloon for rectal distension. Data were analyzed by observers blind neurologic diagnosis. Disease duration shorter MSA than PD group (6 + 4 versus 10 5 yrs, p <0.05). Most reported bowel frequency of less...
In patients with constipation the prevalence of melanosis in rectal biopsies was evaluated an attempt to correlate its occurrence laxative consumption and intestinal stasis. Melanosis present 58 percent none a control group. 73.4 consuming anthracene laxatives 26.6 those not (P less than 0.01). No correlation found between (and grading) pattern transit through large bowel, bowel movements, duration symptoms. Results this study seem indicate that stasis is cause colon rectum confirm may well...
AIM:To assess the prevalence of bowel dysfunction in hemiplegic patients, and its relationship with site neurological lesion, physical immobilization pharmacotherapy. METHODS:Ninety consecutive patients 81 orthopedic were investigated during motor rehabilitation same period, center on diet.All subjects interviewed ≥ 3 mo after injury using a questionnaire inquiring about habits before at time interview.Patients' mobility was evaluated by Adapted Patient Evaluation Conference System.Drugs...
Abstract Idiopathic achalasia is a rare disorder of the oesophagus unknown aetio‐pathogenesis characterized by myenteric inflammation, aperistalsis and insufficient lower oesophageal sphincter relaxation. Vasoactive intestinal peptide (VIP), present in plexus, involved smooth muscle relaxation acts as an anti‐inflammatory cytokine. The human VIP receptor 1 gene (VIPR1) highly polymorphic may play role idiopathic achalasia. One hundred four consecutive patients 300 random controls from same...
Background/aims Oro-pharyngeal dysfunction has been reported in Amyotrophic Lateral Sclerosis (ALS). We aimed to assess ALS patients upper gastrointestinal (GI) motor activity and GI symptoms according bulbar spinal onset severity of ALS. Methods (B) (S) with Functional Rating Scale (ALSFRS-r) ≥35, sub-score ≥10, Forced Vital Capacity (FVC) &gt;50%, underwent to: Fiberoptic Endoscopic Evaluation Swallowing (FEES); esophageal manometry; gastric emptying; Rome symptom questionnaire....
Abstract Background Irritable bowel syndrome (IBS) and functional dyspepsia (FD) show considerable overlap are both associated with psychiatric comorbidity. The present study aimed to investigate whether IBS patients FD higher levels of psychopathology than those without FD. As a preliminary analysis, it also evaluated the psychopathological differences, if any, between featuring two Rome III-defined subtypes, i.e. postprandial distress (PDS) epigastric pain (EPS). Methods Consecutive...
In obese patients with hiatal hernia (HH), laparoscopic sleeve gastrectomy (LSG) cruroplasty is an option but use of prosthetic mesh crura reinforcement debated. The aim was to compare the results closure or without buttressing during LSG. Gastroesophageal reflux disease (GERD) assessed by Health-Related Quality Life (GERD-HRQL) questionnaire before and after surgery in two consecutive series esophageal hiatus ≤ 4 cm2. After LSG, group A (12) underwent simple cruroplasty, whereas B (17),...
Constipation, one of the adverse effects opioid therapy with a major impact on quality life, is still an unmet need for cancer patients, particularly those advanced and progressive disease, non-cancer patients chronically treated opioids. The awareness this condition poor among healthcare providers, despite recent publication guidelines consensus conferences. An early multidisciplinary approach opioid-induced bowel dysfunction (OIBD), based available therapies proven effectiveness, could...
In patients with rectal cancer, surgery and chemoradiotherapy may affect anal sphincter function. Few studies have evaluated anorectal function after neoadjuvant (n-CRT) and/or transanal endoscopic microsurgery (TEM). The aim of this study was to evaluate the effects n-CRT TEM on function.Thirty-seven cancer underwent manometry Wexner scoring for faecal incontinence at baseline, (cT2-T3N0 cancer) 4 12 months surgery. Water-perfused measured tone rest during squeezing, sensitivity compliance....
Objective To date, two questionnaires investigating the symptoms of gastroesophageal reflux disease (GERD) (Quality Life Reflux and Dyspepsia Disease Questionnaire) are validated in Italian, but neither was correlated with an instrumental examination. The aim present study is to improve GERD-Health Related Quality (HRQL) questionnaire, evaluate reliability validity its Italian translation, sensitivity specificity. Methods A modified GERD-HRQL (MI-GERD-HRQL) questionnaire developed adding six...
We looked at laxative consumption and its relationship to bowel habits, total gastrointestinal transit time (TGITT), symptoms in patients with chronic nonorganic constipation. Of the patients, 87.9% used laxative, 30% habitually. Laxative intake increased age, so that habitual was more frequent long-standing (greater than 10 years) Although users had a consistent trend toward lower frequency prolonged TGITT, no found among observed frequency, or large segmental time. laxatives induced...
Purpose: Effects of laparoscopic sleeve gastrectomy (LSG) on gastroesophageal reflux disease (GERD) symptoms are controversial. Our aim is to evaluate the effects LSG GERD in obese patients using a validated quality-of-life questionnaire. Methods: Records 100 (median body mass index [BMI] 44.4 kg/m2, range 35-63.6) without hiatal hernia or severe were analyzed. evaluated by Health-Related Quality-of-Life (HRQL) questionnaire before and after surgery. Weight loss comorbidity resolution...