A5089213146- Viral gastroenteritis research and epidemiology
- Listeria monocytogenes in Food Safety
- Bacterial biofilms and quorum sensing
- Essential Oils and Antimicrobial Activity
- Infant Nutrition and Health
- Virus-based gene therapy research
- Nanoparticles: synthesis and applications
- Microbial Inactivation Methods
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Antimicrobial Resistance in Staphylococcus
- Advancements in Transdermal Drug Delivery
- Respiratory viral infections research
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- Viral-associated cancers and disorders
- Mycobacterium research and diagnosis
- Toxin Mechanisms and Immunotoxins
- Cystic Fibrosis Research Advances
- Urinary Tract Infections Management
- Anesthesia and Neurotoxicity Research
- Vibrio bacteria research studies
- Animal Virus Infections Studies
- Coconut Research and Applications
Istituto Superiore di Sanità
2015-2025
National Institute of Health
2008-2016
Joint Research Centre
2015
Università Campus Bio-Medico
2001
Sapienza University of Rome
2000
University of Messina
1996-1997
GTx (United States)
1996
Urinary tract infections (UTIs) are among the most common worldwide. Uropathogenic Escherichia coli (UPECs) main causative agent of UTIs. UPECs initially colonize human host adhering to bladder epithelium. Adhesion is followed by bacterial invasion urothelial epithelial cells where they can replicate form compact aggregates intracellular bacteria with biofilm-like properties. UPEC strains may persist within cells, thus acting as quiescent reservoirs (QIRs). It has been proposed that cell...
The aim of the present work is to develop nanoemulsions (NEs), nanosized emulsions, manufactured for improving delivery active pharmaceutical ingredients. In particular, composed Neem seed oil, contain rich bioactive components, and Tween 20 as nonionic surfactant were prepared. A mean droplet size ranging from 10 100 nm was obtained by modulating oil/surfactant ratio. Physicochemical characterisation carried out evaluating size, ζ-potential, microviscosity, polarity turbidity external shell...
Chemical fingerprints of four different Satureja montana L. essential oils (SEOs) were assayed by an untargeted metabolomics approach based on Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry (MS) coupled with either electrospray ionization or atmospheric pressure chemical sources. Analysis and relative quantification the non-polar volatile fraction conducted gas chromatography (GC) to MS. FT-ICR MS confirmed significant differences in polar metabolite composition, while...
The ability to produce slime and express a slime-associated antigen was examined in collection of staphylococcal clinical isolates. Slime-producing strains were found among coagulase-negative staphylococci percentages comparable those reported other studies; surprisingly, high percentage Staphylococcus aureus also able this extracellular material. In the latter case, strongly dependent on presence an additional carbohydrate source growth medium. Expression appeared be species specific...
Pseudomonas aeruginosa and Burkholderia cenocepacia are predominant opportunistic pathogens in cystic fibrosis (CF) patients. In healthy humans the lower respiratory tract as well all mucosa, contains a very low free iron concentration (10(-18) M), while CF patients sputum is high, showing median value of 63x10(-6) M. Accumulation catalytic reactive heavily contributes to subsequent clinical complications lung disorders by production oxygen species increases bacterial growth virulence. The...
Bovine lactoferrin (bLf) is a multifunctional glycoprotein that plays an important role in innate immunity against infections, including influenza. Here we have dissected bLf into its C- and N-lobes show inhibition of influenza virus hemagglutination cell infection entirely attributable to the C-lobe all major subtypes, H1N1 H3N2, are inhibited. By far-western blotting sequencing studies, demonstrate strongly binds HA2 region viral hemagglutinin, precisely highly conserved containing fusion...
Most clinical isolates of both Staphylococcus aureus and epidermidis show the capacity to adhere abiotic surfaces develop biofilms resulting in a contribution chronic human skin infections. Antibiotic resistance poor biofilm penetration are main causes ineffective therapeutic treatment killing bacteria within biofilms. A possible strategy could be represented by drug delivery systems, such as nanoemulsions (composed bioactive oil, surfactant water phase), which useful for enhancing...
Bovine lactoferrin (bLf) is an iron-binding glycoprotein folded in two symmetric globular lobes (N- and C-lobes) with potent antimicrobial immunomodulatory activities. Recently, we have shown that bLf, particular its C-lobe, interacts influenza A virus hemagglutinin prevents infection by different H1 H3 viral subtypes. Influenza (HA), highly conserved fusion peptide involved the low-pH-mediated process, plays a significant role early steps of represents attractive target for development...
Stenotrophomonas maltophilia is an emerging nosocomial bacterial pathogen which currently isolated with increasing frequency from the airways of cystic fibrosis (CF) patients. In this study 13 S. strains (11 independent CF patients, and two non-CF respiratory reference strains) have been characterized for expression several virulence-associated factors. particular, ability to form biofilm on abiotic surfaces has determined correlated different features, such as motility, adherence invade...
Listeria monocytogenes is the agent of listeriosis, a food-borne disease. It represents serious problem for food industry because its environmental persistence mainly due to ability form biofilm on variety surfaces. Microrganisms attached surfaces are potential source contamination environment and animals humans. Titanium dioxide nanoparticles (TiO2 NPs) used in products it was reported that daily exposure these nanomaterials very high. Anti-listerial activity TiO2 NPs investigated only with...
Antibiotic resistance is one of the major threats to public health, with an increasing number deaths annually and respiratory tract infections are considered a leading cause global death, particularly in vulnerable populations. It therefore extremely urgent find new therapeutic strategies overcome this problem these represented by design aerosolizable nanoformulations (NEs). In work we designed NEs composed mixture Rosmarinus officinalis Thymus vulgaris essential oils aiming obtain active...
ABSTRACT We have studied the influence of periplasmic Cu,Zn superoxide dismutase on intracellular survival Escherichia coli strains able to invade epithelial cells by expression inv gene from Yersinia pseudotuberculosis but unable multiply intracellularly. Intracellular viability assays, confirmed electron microscopy observations, showed that invasive E. engineered increase production are much more resistant killing than containing only chromosomal sodC copy. However, we found a slight...
Journal Article Acid adaptation and survival of Listeria monocytogenes in Italian‐style soft cheeses Get access G. Cataldo, Cataldo Department Public Health Sciences, University La Sapienza, Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar M.P. Conte, Conte F. Chiarini, Chiarini L. Seganti, Seganti M.G. Ammendolia, Ammendolia Technology Health, National Institute Superti, Superti C. Longhi Catia Longhi, Section, Microbiology, P.le Aldo Moro 5, 00185 Italy....
Influenza is a highly contagious, acute respiratory illness, which represents one of the main plagues worldwide. Even though some antiviral drugs are available, alarming increase virus strains resistant to them highlights need find new compounds. As we have recently demonstrated that bovine lactoferrin (bLf) prevents influenza virus-induced apoptosis, in present wor,k attempted investigate depth mechanism anti-influenza effect this protein. To aim, experiments been carried out whereby...