A5009685899- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Estrogen and related hormone effects
- Nanoparticles: synthesis and applications
- Pesticide Exposure and Toxicity
- Sex and Gender in Healthcare
- Birth, Development, and Health
- Agricultural safety and regulations
- Heavy Metal Exposure and Toxicity
- Science, Research, and Medicine
- Pharmaceutical studies and practices
- Immunotoxicology and immune responses
- Air Quality and Health Impacts
- Pesticide Residue Analysis and Safety
- Hormonal and reproductive studies
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Textile materials and evaluations
- Circular RNAs in diseases
- Pregnancy and Medication Impact
- Pesticide and Herbicide Environmental Studies
- Drug Transport and Resistance Mechanisms
Istituto Superiore di Sanità
2015-2025
Joint Research Centre
2015
Weatherford College
2013
The study explored possible reproductive and endocrine effects of short-term (5 days) oral exposure to anatase TiO2 nanoparticles (0, 1, 2 mg/kg body weight per day) in rat. Nanoparticles were characterised by scanning electron microscopy (SEM) transmission microscopy, their presence spleen, a target organ for bioaccumulation, was investigated single-particle inductively coupled plasma mass spectrometry SEM/energy-dispersive X-ray. Analyses included serum hormone levels (testosterone,...
Organophosphorus insecticides, as Chlorpyrifos (CPF), are widely used in agriculture and against household pests; these compounds receive an increasing consideration potential endocrine disrupters. The aim of the present study was to examine short- long-term effects CPF on thyroid adrenal glands CD1 mice following exposure at dose levels not inducing brain acetyl cholinesterase (AchE) inhibition, during gestational and/or postnatal vulnerable phases. Pregnant dams were treated with 0, 3, 6...
Abstract Bisphenol A (BPA) is a widespread endocrine disrupter mainly used in food contact plastics. Much evidence supports the adverse effects of BPA, particularly on susceptible groups such as pregnant women. The present study considered placental development – relevant for pregnancy outcomes and fetal nutrition/programming potential target BPA. Pregnant CD‐1 mice were administered per os with vehicle, 0.5 (BPA05) or 50 mg kg −1 (BPA50) body weight day from gestational (GD) 1 to GD11. At...
Beauvericin (BEA) and Enniatins (ENN) are mycotoxins produced by Fusarium fungi detected in food feed; there insufficient data to establish their reference values. To evaluate BEA ENN oral toxicity, an integrated approach was applied. Among ENN, Enniatin B (ENNB) selected as test substance. The is composed by: i) vitro acute vivo genotoxicity tests; ii) a repeated‐dose toxicity study focused on genotoxic, immune, endocrine, nervous endpoints the reproductive/developmental screening. For BEA,...
Liver cancers in children are rare representing only 1.1% of malignancies, with an annual incidence rate 1.5 cases per million. Hepatoblastoma and hepatocellular carcinomas the most common malignancies liver occurring young people aged 15 years or younger. Molecular basis both tumors still unclear, markers (i.e., CTNNB1, APC, IGF-2) not always useful characterization sporadic forms; this respect, microRNA recently associated carcinogenesis could play a pivotal role their onset. CTNNB1 APC...
Increasing evidence from animal and human studies indicates that chlorpyrifos (CPF), similar to other organophosphorus insecticides still widely used, is a developmental neurotoxicant. Developmental exposure CPF in rodents induces sex-dimorphic behavioral changes at adulthood, including social agonistic responses, which suggests may interfere with maturation of neuroendocrine mechanisms.We assessed the hypothesis affects levels neurohypophyseal hormones acting as modulators behavior mammals,...
This study is aimed at elucidating the possible protective effects of Nigella sativa oil (NSO) in alleviating toxicity chlorpyrifos (CPF) on reproductive performance male rats. Animals were orally administered with NSO (1 ml/kg/day), CPF (20 mg/kg/day), and + every day for 4 weeks. Results showed that decreased spermatid number, sperm count, daily production, motility while increased dead abnormal compared control. Also levels testosterone, thyroxine levels, steroidogenic enzyme...
Abstract Background Individuals whose gender identity differs from the biological sex and social norms are defined as transgender. Sometimes transgender undergo affirming hormone therapy, which lasts for entire life making essential to evaluate its potential long-term effects. Moreover, can represent a susceptible sub-group of population specific attention is needed in risk assessment, including development targeted animal models. Aim study implementation rodent demasculinizing–feminizing...
<b><i>Background/Aims:</i></b> Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants and have shown endocrine disruption properties in experimental studies. The aim of this study was to investigate the association between exposure PBDEs alterations puberty girls referred for idiopathic central precocious (ICPP) premature thelarche (PT). <b><i>Methods:</i></b> A case-control conducted 124 girls: 37 with ICPP (mean age 7.4 ±...
Transgender (TG) describes individuals whose gender identity differs from the social norms. TG people undergoing gender-affirming hormone therapy (HT) may be considered a sub-group of population susceptible to environmental contaminants for their targets and modes action. The aim this study is set appropriate HT doses identify specific biomarkers implement animal models. Four adult rats/group/sex were subcutaneously exposed three (plus control) selected starting available data....
Transgender (TG) people are individuals whose gender identity and sex assigned at birth do not match. They often undergo gender-affirming hormone therapy (GAHT), a medical intervention that allows the acquisition of secondary characteristics more aligned with their individual identity, providing consistent results in improvement numerous socio-psychological variables. However, GAHT targets different body systems, some side effects recorded, although yet fully identified characterized....