A5029224396- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Obstructive Sleep Apnea Research
- Neonatal Respiratory Health Research
- Voice and Speech Disorders
- Congenital Diaphragmatic Hernia Studies
- Dysphagia Assessment and Management
- interferon and immune responses
- Tracheal and airway disorders
- Gut microbiota and health
- Pneumonia and Respiratory Infections
- Full-Duplex Wireless Communications
- Proteoglycans and glycosaminoglycans research
- Polyomavirus and related diseases
- Cervical Cancer and HPV Research
- Antenna Design and Analysis
- Gastroesophageal reflux and treatments
- Nasal Surgery and Airway Studies
- Viral Infections and Vectors
- Head and Neck Cancer Studies
- Cystic Fibrosis Research Advances
- Extracellular vesicles in disease
- Vascular anomalies and interventions
Sapienza University of Rome
2020-2024
Agostino Gemelli University Polyclinic
2021-2023
Istituto Pasteur
2019-2022
Policlinico Umberto I
2020-2022
Università Campus Bio-Medico
2015-2020
ObjectivesTo scrutinize whether the high circulation of respiratory syncytial virus (RSV) observed in 2021-2022 and 2022-2023 was due to viral diversity, we characterized RSV-A -B strains causing bronchiolitis Rome, before after COVID-19 pandemic.MethodsRSV-positive samples, prospectively collected from infants hospitalized for 2017-2018 2022-2023, were sequenced G gene; phylogenetic results amino acid substitutions analyzed. Subtype-specific data compared among seasons.ResultsPredominance...
Abstract Aim Emergency room admissions have decreased globally during the COVID‐19 pandemic, particularly for respiratory diseases. We evaluated hospital diseases in first year of Italian pandemic and compared them with corresponding period 2016–2017. Methods The study was carried out at Sapienza University Rome, Italy, covered 9 March to 28 February 2020–2021 tested 85 hospitalised children who were negative virus that causes 476 from 2016–2017, as we had also nasal washing samples 14...
Human papillomaviruses (HPVs) commonly infect the anogenital mucosa; most infections are transient, but a fraction of those caused by high-risk (HR) types persist and may lead to cancer. The epidemiology HPV genotypes in anal groups at different risk for cancer has not been well described Italy. This retrospective study reports results DNA testing complete genotyping performed on swabs from 691 female male patients attending proctology clinics Rome during 2012–2021; one-third had repeated...
Children generally develop a mild disease after SARS-CoV-2 infection whereas older adults are at risk of developing severe COVID-19. Recent transcriptomic analysis showed pre-activated innate immunity in children, resulting more effective anti-SARS-CoV-2 response upon infection. To further characterize age-related differences, we studied type I and III interferon (IFN) infected non-infected individuals different ages. Specifically, levels expression (IFN-α, -β, -ε -ω), (IFN-λ1, -λ2 -λ3) IFNs...
Following the pandemic restrictions, epidemiology of respiratory syncytial virus (RSV) has changed, leading to intense hospitalization peaks. This study, conducted at multiple sites in Italy, aimed describe temporal dynamics two post-COVID-19 RSV epidemics. Additionally, circulating RSV-A and -B lineages were characterized compared those found 2018 2019. Respiratory specimens data collected from RSV-positive patients, both inpatients, outpatients, all ages three north-central Italy. To...
A study of respiratory syncytial virus-A (RSV A) genotype ON1 genetic variability and clinical severity in infants hospitalized with bronchiolitis over 6 epidemic seasons (2012-2013 to 2017-2018) was carried out.From prospectively enrolled term for bronchiolitis, samples positive RSV (N = 139) were sequenced the second half G gene. Patients' data obtained from medical files each infant assigned a score. ANOVA comparison adjusted multinomial logistic regression used evaluate score...
Respiratory Syncytial Virus (RSV) is the leading cause of bronchiolitis, and severity may be influenced by bacterial ecosystem. Our aim was to analyze nasal microbiota from 48 infants affected bronchiolitis RSV virus 28 with but negative for virus. Results showed a significantly lower biodiversity in RSV-positive group respect RSV-negative group, specific microbial profile associated different that observed significant modifications relative abundance taxa as well RSV-A group. Furthermore,...
Objective: HIV-1-associated dysbiosis is most commonly characterized by overall decreased diversity, with abundance of the genus Prevotella, recently related to inflammatory responses. Design: A pilot study including 10 antiretroviral therapy-treated HIV-1-infected men and 50 uninfected controls was performed identify main gut determinants (e.g. Prevotella enrichment), that may affect mucosal antiviral defenses T cell immunity in individuals. Methods: 16rRNA gene sequencing applied...
Italy was one of the most affected nations by coronavirus disease 2019 outside China. The infections, initially limited to Northern Italy, spread all other Italian regions. This study aims provide a snapshot severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemiology based on single-center laboratory experience in Rome. retrospectively included 6565 subjects tested for SARS-CoV-2 at Laboratory Virology Sapienza University Hospital Rome from 6 March 4 May. A total 9995 clinical...
Alteration of micro-RNAs (miRNAs) expression, including miRNA-122a, -146a and -205 family members, can have profound effects on inflammatory IFN pathways (miRNA-146a), known as hallmarks COVID-19. SARS-CoV-2-infected patients were recruited at Policlinico Umberto I Hospital Sapienza University Rome (Italy). MiRNA-122a, -146a, IFI27 (Interferon Alpha Inducible Protein 27) levels screened in SARS-CoV-2 (n = 14) healthy controls 10) by real-time RT-PCR assays. Then, miRNA-146a rs2910164 GC...
The aims of this study were to characterize new SARS-CoV-2 genomes sampled all over Italy and reconstruct the origin evolutionary dynamics in Europe between February June 2020. cluster analysis showed only small clusters including < 80 Italian isolates, while most strains intermixed whole tree. Pure observed mainly after lockdown distancing measures adopted. Lineage B B.1 spread late January early 2020, from China Veneto Lombardy, respectively. B.1.1 (20B) probably evolved within central...
The persistence of high-risk (HR) human papillomavirus (HPV) genotypes is a prerequisite cervical cancer. It not clear whether and how bacterial vaginosis (BV) sexually transmitted infections (STIs) cause higher rates persistent HPV infection. This study aimed to characterize mucosal innate immunity HPV, comparing different conditions. Specifically, expression levels genes coding for Toll-like receptors (TLR)7 9, several type III Interferon-related (IFNL1, 2, 3, their specific receptor...
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a global pandemic. Our goal was to determine whether co-infections with respiratory polyomaviruses, such as Karolinska Institutet polyomavirus (KIPyV) and Washington University (WUPyV) occur in SARS-CoV-2 infected patients. Oropharyngeal swabs from 150 individuals, 112 symptomatic COVID-19 patients 38 healthcare workers not by SARS-CoV-2, were collected March 2020 through May tested for KIPyV WUPyV DNA presence....
The management of parapharyngeal tumor is surgical, but the approach remains a challenge. Attention should be paid to avoidance intra-operative bleeding or cranial nerves damage. We report case 67-year-old male complaining left-ear fullness. A submucosal mass arising from lateral wall oropharynx on left side was observed. Magnetic resonance imaging detected parotid gland, in particular deep lobe, and fine needle biopsy compatible with "Warthin tumor." performed mini-invasive transoral under...
Background. Video-assisted endoscopic radiofrequency inferior turbinate volume reduction (RFVTR) is one of the most common surgical therapies for hypertrophy (ITH). Despite all technical and advancement, it advisable to reduce as low possible intraoperative discomfort. The aim this study evaluate role music in reducing patient discomfort during RFVTR. Materials Methods. Twenty-three patients with chronic nasal obstruction due ITH candidate RFVTR are included. Before procedure each filled a...