A5020315223- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Pediatric Pain Management Techniques
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal motility and disorders
- Food Allergy and Anaphylaxis Research
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders Research
- Mindfulness and Compassion Interventions
- Neonatal Respiratory Health Research
- Child Nutrition and Feeding Issues
- Helicobacter pylori-related gastroenterology studies
- Adolescent and Pediatric Healthcare
- Gastrointestinal disorders and treatments
- IL-33, ST2, and ILC Pathways
- Acute Lymphoblastic Leukemia research
- Urticaria and Related Conditions
- Pregnancy and Medication Impact
- Stress Responses and Cortisol
- Frailty in Older Adults
- Intestinal Malrotation and Obstruction Disorders
- Health, psychology, and well-being
- Anorectal Disease Treatments and Outcomes
- Lymphoma Diagnosis and Treatment
Mälardalen University
2017-2024
Karolinska Institutet
2012-2024
Västmanlands sjukhus Västerås
2014-2022
Uppsala University
2011-2022
Karolinska University Hospital
2006-2009
Children and adolescents with Crohn's disease (CD) present often a more complicated course compared to adult patients. In addition, the potential impact of CD on growth, pubertal emotional development patients underlines need for specific management strategy pediatric-onset CD. To develop first evidenced based consensus driven guidelines an expert panel 33 IBD specialists was formed after open call within European Colitis Organisation Society Pediatric Gastroenterolog, Hepatology Nutrition....
We aimed to provide an evidence-supported update of the ECCO-ESPGHAN guideline on medical management paediatric Crohn's disease [CD].
ABSTRACT Background and Aims: Pediatric ulcerative colitis (UC) shares many features with adult‐onset disease but there are some unique considerations; therefore, therapeutic approaches have to be adapted these particular needs. We aimed formulate guidelines for managing UC in children based on a systematic review (SR) of the literature robust consensus process. The present article is product joint effort European Crohn's Colitis Organization (ECCO) Society Paediatric Gastroenterology,...
Summary Background Adverse events leading to discontinuation or dose reduction of thiopurine therapy occur in 9–28% patients with inflammatory bowel disease. Aims To evaluate the influence methyltransferase status and metabolites a large patient population for risk developing adverse event. Methods Three hundred sixty‐four disease present previous were identified from local database. Results The event observed 124 (34%) more common adults than children (40% vs. 15%; P < 0.001) low...
Purpose: The Swedish National Patient Register (NPR) is often used in observational studies of childhood-onset inflammatory bowel disease (IBD) (< 18 years age) and its subtypes, but the validity previously register-based algorithms for capturing IBD has never been examined. Methods: We identified a random sample 233 individuals with at least two first ever diagnostic listings NPR between 2002 2014. calculated test characteristics different definitions subtypes using Copenhagen criteria...
The combination of the severity pediatric-onset inflammatory bowel disease (IBD) phenotypes and need for intense medical treatment may increase risk malignancy mortality, but evidence regarding extent problem is scarce. Therefore, Porto Pediatric IBD working group ESPGHAN conducted a multinational-based survey cancer mortality in pediatric IBD.A among gastroenterologists 20 European countries Israel on and/or patient population with was undertaken. One representative from each country...
Introduction: Whether data on International Classification of Diseases (ICD)-codes from the Swedish National Patient Register (NPR) correctly correspond to subtypes inflammatory bowel disease (IBD) and phenotypes Montreal classification scheme among patients with prevalent is unknown.Materials methods: We obtained information IBD medical records 1403 known who underwent biological treatment at ten hospitals retrieved their IBD-associated diagnostic codes NPR. used previously described...
Summary Background Risk benefit strategies in managing inflammatory bowel diseases (IBD) are dependent upon understanding the risks of uncontrolled inflammation vs those treatments. Malignancy and mortality IBD have been associated with disease‐related immune suppression, but data limited due to their rare occurrence. Aim To identify describe most common causes mortality, types cancer previous or current therapy among children young adults paediatric‐onset IBD. Methods Information on...
Objective. Childhood onset Crohn's disease (CD) is considered more aggressive than adult disease. Epithelioid cell granulomas in intestinal biopsies are one, non-obligate, criterion of CD. We investigated as markers CD severity children followed to adulthood. Material and methods. Forty-five individuals with childhood were studied from diagnosis until attainment final height, data on location, medical surgical management detailed growth analyses. A blinded review diagnostic was also...
Earlier studies have provided varying risk estimates for lymphoma in patients with inflammatory bowel disease (IBD), but often been limited by detection biases (especially during the first year of follow-up evaluation), misclassification, and small sample size; rarely reflect modern-day management IBD.We performed a binational register-based cohort study (Sweden Denmark) from 1969 to 2019. We compared 164,716 IBD 1,639,027 matched general population reference individuals. Cox regression...
Background Real-life long-term data on infliximab treatment in ulcerative colitis are limited. Aim To study the efficacy and safety of chronic active possible predictors colectomy response were also examined. Methods A retrospective multi-centre 250 patients with inclusion criteria: age ≥18 years, ambulatory treated, steroid-dependent or intolerant and/or immunomodulator refractory intolerant. Results Steroid-free clinical remission was achieved by 123/250 (49.2%) at 12 months 126/250 a...
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy causing severe acute gastrointestinal symptoms and lethargy, mainly affecting infants young children. There are geographic variations in its clinical features. This study aimed to describe the characteristics management of FPIES Swedish children.The included children who presented with during 2008-2017. All pediatric departments (n = 32) were invited report their known patients. Data collected through...
Background & AimsIndividuals with inflammatory bowel disease (IBD) are at increased risk of serious infections, but whether this varies by histologic activity is unclear.MethodsThis was a national population-based study 55,626 individuals diagnosed IBD in 1990 to 2016 longitudinal data on ileocolorectal biopsy specimens followed up through 2016. Serious infections were defined as having an inpatient infectious diagnosis the Swedish National Patient Register. We used Cox regression estimate...
Background: Perianal diseases are more common in patients with Crohn's disease (CD) than the general population, but data scarce other inflammatory bowel (IBD) subtypes.
Abstract Aim: Due to parental concern regarding the child's bowel habits and ongoing discussion whether there might be an association between autism intestinal inflammation, two inflammatory markers were analysed in a group of children with autism. Methods: Twenty‐four consecutive (3–13 years) unknown aetiology investigated respect faecal calprotectin rectal nitric oxide (NO). Results: One child who previously had severe Clostridium difficile infection displayed raised levels both these one...
The role of trough serum infliximab (s-IFX) and antibodies toward IFX (ATI) during maintenance treatment remains unclear in children. aim the present study was to investigate s-IFX ATI identify any correlation with inflammatory activity clinical response a pediatric bowel disease (IBD) cohort. We investigated levels IBD patients (n = 45) on treatment. Ninety-three blood samples were collected demographics, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin recorded. mean...
Inflammatory bowel disease [IBD] has been associated with spondyloarthritis [SpA], but population-based estimates are scarce. Here we compare the occurrence of SpA before and after a diagnosis IBD general population, overall by subtype age.We used nationwide register-based cohort study 39 203 patients diagnosed during 2006-2016, identified from Swedish registers gastrointestinal biopsy data, 390 490 matched reference individuals population. Conditional logistic regression models were to...
Exclusive Enteral Nutrition (EEN) is the first-line treatment in children with Crohn’s disease (CD) for induction of remission. However, mode action remains conjectural. The aim this study was to investigate whether effect EEN paralleled by changes mucosal cytokine profiles (MCP). Twelve new onset inflammatory bowel (IBD) received a polymeric EEN. We assessed clinical, endoscopic and histologic scoring before after colonic cytokines were analyzed Polymerase Chain Reaction (PCR) six IBD...
Introduction Infliximab was launched for the treatment of Crohn's disease (CD) in 1999. We set up a follow-up protocol to meticulously study development with repeated infusions infliximab. Aim To follow effects infliximab on activity, blood chemistry, quality life, plasma nitrite, and titers Saccharomyces cerevisiae antibodies (ASCA). Methods During 1999–2008, CD patients were monitored activity by Harvey–Bradshaw index, chemistry hemoglobin, albumin, C-reactive protein, platelet count,...
Abstract Background Functional abdominal pain disorders (FAPDs) affect children, especially girls, all over the world. The evidence for existing treatments is mixed, and effective accessible are needed. Dance, a rhythmic cardio‐respiratory activity, combined with yoga, which enhances relaxation focus, may provide physiological psychological benefits that could help to ease pain. Objectives aim of this study was evaluate effect dance yoga intervention on maximum in 9‐ 13‐year‐ old girls...