A5102792654- Colorectal Cancer Surgical Treatments
- Inflammatory Bowel Disease
- Diverticular Disease and Complications
- Stoma care and complications
- Helicobacter pylori-related gastroenterology studies
- Patient-Provider Communication in Healthcare
- Cancer survivorship and care
- Glycosylation and Glycoproteins Research
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Palliative Care and End-of-Life Issues
- Appendicitis Diagnosis and Management
- Galectins and Cancer Biology
- Colorectal Cancer Screening and Detection
- Gallbladder and Bile Duct Disorders
- Studies on Chitinases and Chitosanases
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Ultrasound and Hyperthermia Applications
- Inflammation biomarkers and pathways
- Abdominal Surgery and Complications
- IL-33, ST2, and ILC Pathways
- Kawasaki Disease and Coronary Complications
- COVID-19 and healthcare impacts
- Photoacoustic and Ultrasonic Imaging
Sahlgrenska University Hospital
2015-2023
University of Gothenburg
2012-2023
Region Västra Götaland
2019-2023
Lund University
2005
Henry Ford Hospital
1981
Several factors and patient characteristics influence the risk of surgical wound dehiscence incisional hernia after midline laparotomy. The purpose this study was to investigate whether a specified, or not suture quota in operative report affects incidence complications describe previously known for these complications. Retrospective data collection from medical records all vascular procedures laparotomies engaging small intestines, colon rectum performed 2010. Patients were enrolled four...
Introduction: Whether data on International Classification of Diseases (ICD)-codes from the Swedish National Patient Register (NPR) correctly correspond to subtypes inflammatory bowel disease (IBD) and phenotypes Montreal classification scheme among patients with prevalent is unknown.Materials methods: We obtained information IBD medical records 1403 known who underwent biological treatment at ten hospitals retrieved their IBD-associated diagnostic codes NPR. used previously described...
Uncontrolled activation of intestinal mononuclear phagocytes [MNPs] drives chronic inflammation in inflammatory bowel disease [IBD]. Triggering receptor expressed on myeloid cells 1 [TREM-1] has been implicated the pathogenesis IBD. However, role TREM-1+ cell subsets driving IBD pathology and link with clinical parameters are not understood. We investigated TREM-1 expression human MNP examined blocking as a potential therapy.TREM-1 gene was analysed mucosa, enriched epithelial lamina propria...
Background and Aims: Loop ileostomies are frequently used as diversion of the fecal stream to protect a distal anastomosis. The aim this study was identify complications morbidity related loop in patients with ulcerative colitis at nonemergent setting. Material Methods: Consecutive who received ileostomy tertiary referral center Sweden from January 2006 until December 2012 were included studied retrospectively. Results: In total, 71 identified, median age 39 years. A majority (94%) underwent...
The aetiology and pathogenesis of ulcerative colitis (UC) are essentially unknown. Galectins carbohydrate-binding lectins involved in a large number physiological pathophysiological processes. Little is known about the role galectins human UC. In this immunohistochemical exploratory study, both epithelial inflammatory cell galectin expression were studied patients with thoroughly documented clinical history correlated activity.Surgical whole intestinal wall colon specimens from UC (n = 22)...
Inflammasomes are intracellular protein complexes whose activation results in proinflammatory cytokines. implicated Crohn´s disease (CD) pathogenesis, yet the contribution of inflammasomes intestinal epithelial cells (IECs) versus lamina propria (LP) macrophages is poorly understood. Whether inflammasome expression tissue reflects serum inflammatory profile patients also not known. We aimed to determine cell types where increased CD and if they correlate with profile. RT-PCR NanoString...
Ileo-rectal anastomosis (IRA) is an option to restore bowel continuity after colectomy in patients with ulcerative colitis (UC). Concerns that the remaining rectum may serve as a site for continuing proctitis subsequent poor function and IRA failure fear of development dysplasia cancer have led abandonment large parts world. This study investigated outcome patient cohort UC regard cancer.This was retrospective data gathering enrolled at Department Colorectal Surgery, Surgical Clinic,...
Abstract Background Laparoscopic lavage as a treatment for perforated diverticulitis, Hinchey III, has been found safe and feasible in randomized trials. A few studies have reported functional outcomes quality of life secondary outcomes. This study investigated distress associated with dysfunction the bowel or stoma, outcomes, 2–3 years after surgery national unselected cohort. Methods All patients Sweden who underwent emergency diverticulitis purulent peritonitis (2016–2018) were invited to...
Patients with rectal cancer may undergo treatment such as surgery and (chemo)radiotherapy. Before treatment, patients are informed of different options possible side-effects. The aim the study was to evaluate patients' experience communication healthcare personnel at time diagnosis after one year.A total 1085 from Denmark Sweden were included. They answered a detailed questionnaire year follow-up. Clinical data retrieved national quality registries.Response rates 87% baseline 74% year....
Change in bowel habit as a sole alarm symptom for colorectal cancer is disputed.We investigated the diagnostic value of change cancer, particularly single and within different age groups.This retrospective cohort study examined fast track referrals outcomes across four Swedish hospitals (April 2016-May 2017). Entry criteria constituted one or more three features: anaemia, visible rectal bleeding, than 4 weeks patients over 40 years age. Patients were grouped having only habit, plus...
The standard treatment for Hinchey III perforated diverticulitis with peritonitis was resection or without a stoma, but recent trials have shown that laparoscopic lavage is reasonable alternative. This registry-based Swedish study investigated results at national level to assess safety in real-world scenarios.Patients Sweden who underwent emergency surgery between 2016 and 2018 were studied. Inverse probability weighting by propensity score used adjust confounding factors.A total of 499...
Objective. Patients who undergo ileal pouch-anal anastomosis (IPAA) after colectomy for ulcerative colitis (UC) occasionally have neoplasia in the IPAA. with evidence of dysplasia or carcinoma colorectal specimen may an increased risk such neoplasia. A surveillance program has been suggested. The aims this study were to evaluate outcomes a large patient cohort, and investigate prevalences pouch mucosa anal transitional zone (ATZ). Material methods. total 629 patients underwent IPAA UC at...
Abstract Background Serious infections have been observed in patients with inflammatory bowel disease (IBD) on anti-TNF use—but to what extent these are due or the activity per se is hard disentangle. We aimed describe how rates of serious change over time both before and after starting IBD. Methods Inflammatory naïve treatment were identified at 5 centers participating Swedish IBD Quality Register, their medical records examined detail. infections, defined as requiring in-patient care, year...
There are no prospective trials comparing the two main reconstructive options after colectomy for Ulcerative colitis, ileal pouch anal anastomosis and ileorectal anastomosis. An attempt on a randomized controlled trial has been made but receiving standardized information patients insisted choosing operation themselves.
Patients with colorectal cancer may lack information about the disease and treatment. In 2017, a group consultation before start of surgery was introduced at university hospital in western Sweden to inform disease, treatment, ongoing scientific studies. The primary aim this study explore experience patients attending consultation. Based on semi-structured interviews cancer, questionnaire constructed administered patients, both those not total, 124 were included response rate 86%. A majority...
Reconstructive surgery with ileal pouch-anal anastomosis (IPAA) is the standard procedure after colectomy in patients Ulcerative Colitis (UC) and Familial Adenomatous Polyposis (FAP). It of interest to understand how a generation shift surgeons performing IPAA has affected patients' outcomes.All consecutive who underwent period 1999-2016 at Sahlgrenska University Hospital/Östra, Gothenburg, Sweden, were included. Surgeons representing two different generations performed surgeries during this...
Kock's continent ileostomy is an option after proctocolectomy for patients not suitable IPAA or ileorectal anastomosis. Ulcerative colitis the most common indication ileostomy.The aim of this study was to evaluate long-term outcome ileostomy.Retrospective cohort register study.Data were obtained from Swedish National Patient Registry.All with IBD and a identified. Data on demographics, diagnosis, reoperations, excisions obtained. Patients inconsistent diagnostic coding classified as...
The effects of cholecystectomy and sphincter Oddi bypass on bile acid (BA) metabolism in dogs have been studied. Cholecystectomy decreased the BA pool half-life increased percent taurodeoxycholic pool. A 48-hour fast had no effect total size intact sphincter-of-Oddi-bypassed but caused a marked decrease cholecystectomized dogs. It was concluded that while is unnecessary to maintain fasting dogs, gallbladder is. Alimentation necessary
The same mechanisms by which ultrasound enhances thrombolysis are described in connection with non-beneficial effects of ultrasound. present safety study was therefore designed to explore beneficial characteristics on the infarcted and non-infarcted myocardium. In an open chest porcine model (n = 17), myocardial infarction induced ligating a coronary diagonal branch. Pulsed frequency 1 MHz intensity 0.1 W/cm2 (ISATA) applied during one hour both tissue. These similar those used studies...
Background and Aims: Colectomy due to ulcerative colitis is associated with complications. One severe complication the risk for blow-out of remaining rectal remnant. The aim this study was compare frequency severity complications in patients remnant left subcutaneously versus intra-abdominally. A secondary identify factors Materials Methods: Consecutive at two tertiary centers Sweden were retrospectively reviewed regarding surgical procedures; classified according Clavien–Dindo; possible...
Crohn's disease (CD) is a chronic condition characterized by recurrent flares of inflammation in the gastrointestinal tract. Disease etiology poorly understood and dysregulated immune activation that progressively destroys intestinal tissue. Key cellular compartments pathogenesis are epithelial layer its underlying lamina propria. While epithelium contains predominantly cells, propria enriched cells. Deciphering proteome changes different cell populations important to understand CD...