A5020100253- Celiac Disease Research and Management
- Microscopic Colitis
- Eosinophilic Esophagitis
- Digestive system and related health
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Diabetes and associated disorders
- Pregnancy and Medication Impact
- Gastrointestinal disorders and treatments
- Adolescent and Pediatric Healthcare
- Vitamin D Research Studies
- Obesity, Physical Activity, Diet
- Immunodeficiency and Autoimmune Disorders
- Viral gastroenteritis research and epidemiology
- Infant Nutrition and Health
- Child Nutrition and Water Access
- Microbial Metabolites in Food Biotechnology
- Gastroesophageal reflux and treatments
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Intestinal Malrotation and Obstruction Disorders
- Esophageal and GI Pathology
- Nutrition, Genetics, and Disease
- Gastrointestinal motility and disorders
- Reproductive System and Pregnancy
University of Gothenburg
2019-2025
Drottning Silvias barn- och ungdomssjukhus
2019-2025
Sahlgrenska University Hospital
2023-2024
Norwegian Institute of Public Health
2015-2020
University of Colorado Anschutz Medical Campus
2017-2018
657 Oslo
2018
Karolinska Institutet
2013-2017
University of Oslo
2017
Sachs' Children and Youth Hospital
2015
Karolinska University Hospital
2010-2014
There is a need for consensus on the recommendations follow-up of children and adolescents with celiac disease. Objectives: To gather current evidence to offer management. Methods: The Special Interest Group Celiac Diseases European Society Paediatric Gastroenterology Hepatology Nutrition formulated ten questions considered be essential care. A literature search (January 2010–March 2020) was performed in PubMed or Medline. Relevant publications were identified potentially eligible studies...
Objective We assessed whether early-life diet quality and food intake frequencies were associated with subsequent IBD. Design Prospectively recorded 1-year 3-year questionnaires in children from the All Babies Southeast Sweden The Norwegian Mother, Father Child Cohort Study used to assess using a Healthy Eating Index frequency of groups. IBD was defined as >2 diagnoses national patient registers. Cox regression yielded HRs adjusted (aHRs) for child’s sex, parental IBD, origin, education...
The intestinal microbiota has been proposed to play a pathogenic role in coeliac disease (CD). Although antibiotics are common environmental factors with profound impact on microbiota, data antibiotic use as risk factor for subsequent CD development scarce. In this population-based case–control study we linked nationwide histopathology 2,933 individuals (Marsh stage 3; villous atrophy) the Swedish Prescribed Drug Register examine association between of systemic and CD. We also examined 2,118...
Studies on early life infections and risk of later celiac disease (CD) are inconsistent but have mostly been limited to retrospective designs, inpatient data, or insufficient statistical power. We aimed test whether associated with increased CD using prospective population-based data.This study, based the Norwegian Mother Child Cohort Study, includes prospective, repeated assessments parent-reported infectious data up 18 months age for 72,921 children born between 2000 2009. was identified...
To determine whether infection with human enterovirus or adenovirus, both common intestinal viruses, predicts development of coeliac disease.Case-control study nested within Norwegian birth cohort recruited between 2001 and 2007 followed to September 2016.Norwegian population.Children carrying the HLA genotype DR4-DQ8/DR3-DQ2 conferring increased risk disease.Enterovirus adenovirus detected using real time polymerase chain reaction in monthly stool samples from age 3 36 months.Coeliac...
Celiac disease (CeD) is a chronic autoimmune disorder of global relevance, with the potential for acute and long-term complications. However, economic burden CeD rarely considered largely thought as limited to cost gluten-free food. Fortunately, recent research has shed light on various societal costs across health care continuum. This article summarizes current evidence impacts CeD, which suggest that stretches beyond review provides ample larger but hidden related excess use complications...
BACKGROUND AND OBJECTIVE: Previous research suggests an association of celiac disease (CD) with anorexia nervosa (AN), but data are mostly limited to case reports. We aimed determine whether CD is associated the diagnosis AN. METHODS: Register-based cohort and case-control study including women (n = 17 959) sex- age-matched population-based controls 89 379). (villous atrophy) was identified through histopathology records Sweden’s 28 pathology departments. Inpatient hospital-based outpatient...
Background & AimsCeliac disease (CD) is associated with increased mortality, in part due to cancer. Most studies investigating this cancer risk involved patients diagnosed before widespread increases CD diagnosis rates and access gluten-free food. We performed a population-based study of the CD.MethodsWe identified all Sweden as defined duodenal/jejunal villus atrophy, using Epidemiology Strengthened by histoPathology Reports cohort. Each patient was matched ≤5 controls age, sex, county....
OBJECTIVES: Although earlier studies suggest an increased risk of infectious disease in celiac (CD), data on the influenza patients with CD are limited. We examined hospital admission for patients, but comparative reasons also individuals small-intestinal inflammation or normal mucosa positive serology. METHODS: In 2006–2008, we collected duodenal/jejunal biopsy (Marsh 3: villous atrophy, VA;n=29,008 unique individuals) and 1–2;n=13,200) from all 28 pathology departments Sweden. A third...
Circumstantial evidence links 25-hydroxy vitamin D [25(OH)D], D-binding protein (DBP), D-associated genes, and type 1 diabetes (T1D), but no studies have jointly analyzed these. We aimed to investigate whether DBP levels during pregnancy or at birth were associated with offspring T1D pathway genetic variants modified associations between DBP, 25(OH)D, T1D.From a cohort of >100,000 mother/child pairs, we 189 pairs where the child later developed 576 random control pairs. measured 25(OH)D...
Infections in early life have been linked to type 1 diabetes (T1D) risk, but no previous study has comprehensively analysed exposure antibiotics, acetaminophen and infections during pregnancy childhood relation offspring risk of T1D. Participants the Norwegian Mother Child Cohort Study (n = 114 215 children, whom 403 children were diagnosed with T1D) reported medication use through repeated questionnaires from until 18 months old. Adjusted hazard ratios (aHR) for T1D estimated Cox regression...
OBJECTIVES: To determine the association between amount of gluten intake in childhood and later celiac disease (CD), for which data are currently scarce. METHODS: The prospective Diabetes Autoimmunity Study Young cohort includes 1875 at-risk children with annual estimates (grams/d) from age 1 year. From 1993 through January 2017, 161 children, using repeated tissue transglutaminase (tTGA) screening, were identified CD autoimmunity (CDA) persistent tTGA positivity; these 85 fulfilled criteria...
To examine the association between early-life smoking exposure and later risk of inflammatory bowel disease [IBD]. We followed 115663 participants from Norwegian Mother, Father Child [MoBa] All Babies in Southeast Sweden [ABIS] cohorts birth [1997-2009] through 2021. IBD was identified national patient registers. Validated questionnaire data defined maternal during pregnancy, environmental tobacco smoke [ETS] child ETS by ages 12 36 months. Cox regression used to estimate adjusted hazard...
Abstract Aim To examine possible geographical and temporal differences in the incidence of childhood‐onset inflammatory bowel disease (IBD) Norway, motivated by previous research indicating relevant environmental factors explaining changing epidemiology. Methods We analysed data from children born Norway 2004 to 2012 ( n = 541 036) a registry‐based nationwide study. After validating registry diagnoses against medical records, we defined IBD as ≥2 entries International Classification...
ABSTRACT Background Childhood antibiotic use has been associated with inflammatory bowel disease (IBD), although the potential contribution of infection frequency remains uncertain. Aims To explore association between early‐life infections, antibiotics and IBD development. Methods We used population‐based data from ABIS (Sweden) MoBa (Norway) cohorts following children birth (1997–2009) until 2021. Prospectively collected questionnaires identified (any, gastrointestinal respiratory)...
Turner syndrome (TS) is the most common sex chromosome abnormality in females. Previous research has indicated a high prevalence of celiac disease (CD) TS, but data have mostly been limited to case series at tertiary centers. We aimed examine risk for CD individuals with TS compared general population.This Swedish nationwide case-control study included and controls born 1973-2006. The consisted 2 groups: (1) 7548 females biopsy-verified (villous atrophy; Marsh stage 3) diagnosed until...
The infant microbiota may play a pathogenic role in coeliac disease (CD). Antibiotic treatment pregnancy is common and could significantly impact the microbiota. In this study, we aimed to investigate association between antibiotic exposure during CD offspring.Prospective questionnaire data on were available 8729 children participating All Babies Southeast Sweden (ABIS) cohort of these 46 developed until December 2006. Cox regression estimated hazard ratios (HRs) for offspring among mothers...
To study the association of gluten intake with development islet autoimmunity and progression to type 1 diabetes.The Diabetes Autoimmunity Study in Young (DAISY) follows children an increased risk diabetes. Blood samples were collected at 9, 15, 24 months age, annually thereafter. Islet was defined by appearance least one autoantibody against insulin, IA2, GAD, or ZnT8 (zinc transporter 8) two consecutive blood samples. Using food frequency questionnaires, we estimated (in grams per day)...
Celiac disease (CD) may occur in genetically predisposed individuals exposed to gluten, but it is unclear whether the amount of gluten influences risk disease. We aimed at determining intake age 18 months predicted later CD.In an observational nationwide cohort study, Norwegian Mother and Child Cohort Study (MoBa), we included 67,608 children born during 2000-2009 followed up for a mean 11.5 years (range 7.5-15.5) after exclusions missing data. Information regarding CD diagnosis was obtained...
INTRODUCTION: To determine the risk of inflammatory bowel disease (IBD) in patients with celiac (CeD) (and vice versa ) compared general-population comparators. METHODS: Using Swedish histopathology and healthcare register data, we identified 48,551 CeD 83,529 IBD diagnosed 1969–2016. Each patient was age- sex-matched comparators (CeD: n = 240,136; IBD: 408,195). Cox regression estimated hazard ratios (HRs) for . Our main analyses were limited to events beyond first year follow-up reduce...
Abstract Background Birth cohort studies with linked register-based data on inflammatory bowel disease (IBD) provide opportunities to prospectively study early-life determinants of the disease. However, often lack information clinical characteristics and rely diagnostic algorithms. Within All Babies in Southeast Sweden (ABIS) cohort, we examined validity a definition IBD, its incidence, therapeutic at diagnosis. Methods We followed 16,223 children from birth (1997–1999) until end 2020 for...
Background: A few prospective studies suggest an association between maternal smoking during pregnancy and lower risk of type 1 diabetes. However, the role unmeasured confounding misclassification remains unclear. Methods: We comprehensively evaluated whether in predicts childhood-onset diabetes two Scandinavian cohorts (185,076 children; 689 cases) a Norwegian register-based cohort (434,627 692 cases). measured cord blood cotinine as objective marker nicotine exposure late 154 cases 476...
Conventional or electron microscopy can contribute significantly to the diagnosis of pancreatic endocrine tumours. These techniques, however, are limited value for classification tumours, which should take both clinical and morphological findings into account. In this paper a based on features content peptide hormone-producing cells in tumours is presented.