A5055368205- Folate and B Vitamins Research
- Tryptophan and brain disorders
- Vitamin D Research Studies
- Metabolism and Genetic Disorders
- Nutritional Studies and Diet
- Gut microbiota and health
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Smoking Behavior and Cessation
- Bipolar Disorder and Treatment
- Esophageal and GI Pathology
- RNA modifications and cancer
- Vitamin C and Antioxidants Research
- Neonatal Respiratory Health Research
- Cancer Risks and Factors
- Peroxisome Proliferator-Activated Receptors
- Mental Health Research Topics
- Metabolomics and Mass Spectrometry Studies
- Petroleum Processing and Analysis
- Alcoholism and Thiamine Deficiency
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
Bevital (Norway)
2016-2025
Cambridge University Press
2023
New York University Press
2023
University of Bergen
2010-2022
Haukeland University Hospital
2004-2021
University of California, Berkeley
2016
Cancer Registry of Norway
2011-2015
Norwegian Institute of Public Health
2010-2015
National Health Research Institutes
2015
Imperial College London
2013-2015
Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role early programming for childhood and adult illness. Maternal smoking is major risk factor multiple adverse health outcomes children, but the underlying mechanisms are unclear.We investigated epigenome-wide methylation cord blood of newborns relation maternal during pregnancy.We examined plasma cotinine (an objective biomarker smoking) measured pregnancy at 473,844 CpG sites (CpGs) 1,062...
Abstract Vitamins B 2 and 6 serve as cofactors in enzymatic reactions involved tryptophan homocysteine metabolism. Plasma concentrations of these vitamins amino acids are related to smoking inflammation, correlate with other markers immune activation. Large‐scale studies relations have been hampered by lack suitable analytical methods. The assay described includes riboflavin, five vitamin forms (pyridoxal 5′‐phosphate, pyridoxal, 4‐pyridoxic acid, pyridoxine pyridoxamine), six metabolites...
Objective— Enhanced tryptophan degradation, induced by the proinflammatory cytokine interferon-γ, has been related to cardiovascular disease progression and insulin resistance. We assessed downstream metabolites of kynurenine pathway as predictors acute myocardial infarction in patients with suspected stable angina pectoris. Furthermore, we evaluated potential effect modifications according diagnoses pre-diabetes mellitus or diabetes mellitus. Approach Results— Blood samples were obtained...
We aimed to evaluate 10 biomarkers related inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, 6 kynurenines, as potential predictors of all-cause cause-specific mortality in a general population sample. The study cohort was participants involved community-based Norwegian study, Hordaland Health Study (HUSK). used Cox proportional hazards models assess associations with competing-risk for mortality. Of 7,015 participants,...
Metabolites of tryptophan, produced via the kynurenine pathway (kynurenines), have been linked to Alzheimer's disease (AD) in small cohorts with conflicting results.To compare differences plasma levels between AD and controls identify potential associations cognition.The study included 65 histopathologically-confirmed patients cognitively-screened from Oxford Project Investigate Memory Ageing (OPTIMA) cohort. Cognition was assessed using Cambridge Cognitive Examination (CamCog). Tryptophan,...
Interferon γ (IFN-γ) is centrally involved in atherosclerosis-related inflammation, but its activity cannot be reliably assessed by systemic measurements. In activated macrophages, IFN-γ stimulates production of neopterin and conversion tryptophan to kynurenine. We evaluated the relationships plasma kynurenine:tryptophan ratio (KTR) long-term prognosis patients with stable angina pectoris angiographically verified significant coronary artery disease.Samples were obtained from 2380 a mean age...
SummaryPatients with non-small cell lung cancer (NSCLC) are routinely treated cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism central regulator of cisplatin responses in vitro and vivo. By aggravating bioenergetic catastrophe that involves the depletion intracellular glutathione, exacerbates cisplatin-mediated DNA damage, thus sensitizing large panel lines to apoptosis. Moreover, sensitizes cells apoptosis induction by...
BackgroundThe etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers one-carbon metabolism and RCC onset survival.
Summary Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation serve as markers of cellular immune activation, but data are sparse on other determinants these metabolites the kynurenine pathway. We measured neopterin, tryptophan, kynurenine, anthranilic acid, kynurenic 3-hydroxykynurenine, 3-hydroxyanthranilic acid xanthurenic in plasma two age groups, 45–46 years (n = 3723) 70–72 3329). Differences across categories potential determinants, including age,...
Maternal smoking in pregnancy is associated with adverse health outcomes children, including cancers; underlying mechanisms may include epigenetic modifications. Using Illumina's 450K array, we previously identified differential DNA methylation related to maternal during at 26 CpG sites (CpGs) 10 genes newborn cord bloods from the Norwegian Mother and Child Cohort Study (MoBa). Whether these signals newborns reflect utero exposure only or possibly inheritance of smoking-related modifications...
Targeted metabolic profiling characterized by complementary platforms, multiplexing and low volume consumption are increasingly used for studies using biobank material. Using liquid-liquid extraction, we developed a sample workup suitable quantification of 6 fat- 26 water-soluble biomarkers. 50 μL serum/plasma was mixed with dithioerythritol, ethanol, isooctane/chloroform. The organic layer analysis the fat-soluble vitamins all-trans retinol (A), 25-hydroxyvitamin D2, D3, α-tocopherol (E),...
Maternal smoking during pregnancy, especially when sustained, leads to numerous adverse health outcomes in offspring. Pregnant women disproportionately underreport and smokers tend have lower follow-up rates repeat questionnaires. Missing, incomplete, or inaccurate data on presence duration of pregnancy impairs identification novel effects limits adjustment for studies other exposures. An objective biomarker newborns maternal would be valuable.We developed a sustained using common DNA...
Abstract BACKGROUND Biomarkers and metabolites related to B vitamin function one-carbon metabolism have been studied as predictors of chronic diseases in studies based on samples stored biobanks. For most biomarkers, stability data are lacking or fragmentary. METHODS Degradation accumulation kinetics 32 biomarkers were determined at 23 °C serum plasma (EDTA, heparin, citrate) collected from 16 individuals for up 8 days. In frozen (−25 °C), was cross-sectionally 650 archival 29 years....
Imbalances in tryptophan metabolism have been linked to cancer-related immune escape and implicated several cancers, including lung cancer.