A5066110533- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Hip and Femur Fractures
- Lung Cancer Treatments and Mutations
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Emergency and Acute Care Studies
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Esophageal Cancer Research and Treatment
- Breast Cancer Treatment Studies
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- HER2/EGFR in Cancer Research
- RNA Research and Splicing
- Cardiac, Anesthesia and Surgical Outcomes
- Bladder and Urothelial Cancer Treatments
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Trauma and Emergency Care Studies
- Immune Cell Function and Interaction
- Statistical Methods and Bayesian Inference
King's College London
2020-2025
Inserm
2001-2023
Université Paris-Sud
2011-2023
Institut Gustave Roussy
2009-2023
Institute of Cancer Research
2020
Predict (France)
2019
Prédicteurs moléculaires et nouvelles cibles en oncologie
2019
Cheltenham Festivals
2018
John Wiley & Sons (United Kingdom)
2018
Stoke Mandeville Spinal Research
2018
We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, contribution intratumoral T distribution and functions prognosis significance TIL subpopulations non-small carcinoma (NSCLC) have thus far not been systematically addressed. In this study, we show that an enhanced CD103(+) subset correlates with improved early stage NSCLC patient survival increased...
SummaryPatients with non-small cell lung cancer (NSCLC) are routinely treated cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism central regulator of cisplatin responses in vitro and vivo. By aggravating bioenergetic catastrophe that involves the depletion intracellular glutathione, exacerbates cisplatin-mediated DNA damage, thus sensitizing large panel lines to apoptosis. Moreover, sensitizes cells apoptosis induction by...
The discovery of a targeted therapeutic compound along with its companion predictive biomarker is major goal clinical development for personalized anticancer therapy to date. Here we present evidence the value TLR3 expression by tumor cells efficacy Poly (A:U) dsRNA in 194 breast cancer patients enrolled randomized trial. Adjuvant treatment double-stranded RNA (dsRNA) was associated significant decrease risk metastatic relapse positive but not TLR3-negative cancers. Moreover, show functional...
In spite of adjuvant chemotherapy, a significant fraction patients with localized breast cancer (BC) relapse after optimal treatment. We determined the occurrence cytoplasmic MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3B)-positive puncta, as well presence nuclear HMGB1 (high mobility group box 1) in cells within surgical BC specimens by immunohistochemistry, first test cohort (152 patients) and then validation who all received anthracycline-based chemotherapy (1646...
The spliceosome is a large ribonucleoprotein complex that guides pre-mRNA splicing in eukaryotic cells. Here, we determine whether the could constitute an attractive therapeutic target cancer. Analysis of gene expression arrays from lung, breast, and ovarian cancers datasets revealed several genes encoding components core composed heteroheptameric Sm were overexpressed malignant disease as compared with benign lesions also define subset highly aggressive breast cancers. siRNA-mediated...
Excision repair cross-complementation group 1 (ERCC1) is a protein involved in of DNA platinum adducts and stalled replication forks. We others have previously shown the influence ERCC1 expression upon survival rates benefit cisplatin-based chemotherapy patients with resected non-small-cell lung cancer (NSCLC). However, little known about molecular characteristics ERCC1-positive ERCC1-negative tumors.We took advantage cohort 91 NSCLC, for which we had matched frozen paraffin-embedded samples...
Bioinformatics analyses of pathways and genes differentially expressed between malignant benign lesions could allow discovering new therapeutic targets. Here, we identified Checkpoint kinase 1 (Chk1) as a potent target in triple-negative breast cancer (TNBC).Differential gene expression TNBC, other was performed on two datasets. Chk1 targeted using RNA interference or chemical inhibitor several TNBC cell lines.DNA repair pathway one mostly deregulated compared to lesions. candidate among the...
Standard management in the UK for high-risk stage 1 nonseminoma germ cell tumours of testis (NSGCTT) is two cycles adjuvant bleomycin, etoposide (360 mg/m2), and cisplatin (BE360P) chemotherapy, or surveillance. To test whether one cycle BE500P achieves similar recurrence rates to BE360P. A total 246 patients with vascular invasion–positive NSGCTT combined seminoma + were centrally registered a single-arm prospective study. One comprising bleomycin 30000 IU on days 1, 8, 15, 165 mg/m2 1–3,...
Abstract Objective To determine whether mobilisation timing was associated with the cumulative incidence of hospital discharge by 30 days after hip fracture surgery, accounting for potential confounders and competing risk in-hospital death. Method We examined data 135,105 patients 60 years or older who underwent surgery nonpathological first between 1 January 2014 31 December 2016 in any England Wales. tested incidences differed those mobilised early (within 36 h surgery) late, Results A...
Aims The aim of this study to compare 30-day survival and recovery mobility between patients mobilized early (on the day of, or after surgery for a hip fracture) late (two days more surgery), determine whether presence dementia influences association timing mobilization, survival, recovery. Methods Analysis National Hip Fracture Database hospital records 126,897 aged ≥ 60 years who underwent fracture in England Wales 2014 2016. Using logistic regression, we adjusted covariates with...
The helper T type 1 (Th1) function of CD4+ lymphocytes is presumed to be key importance in host defense against HIV-1. As the production different antibody isotypes dependent on this function, we investigated whether HIV-1-specific responses a particular IgG isotype could reliable marker long-term HIV-1 control. Assessment subclass distribution plasma HIV-1-infected patients enrolled French prospective Asymptomatic Long-Term (ALT) cohort showed that IgG2 directed Env gp41 and Gag proteins...
Summary Estimates of the number prevalent human immunodeficiency virus infections are used in England and Wales to monitor development virus–acquired immune deficiency syndrome epidemic for planning purposes. The population is split into risk groups, estimates group size prevalence diagnosis rates combined derive undiagnosed overall infected individuals. In traditional approaches, each size, or rate parameter must be informed by just one summary statistic. Yet a rich array surveillance other...
Meta-analysis has been well-established for many years, but largely confined to pooling evidence on pair-wise contrasts. Broader forms of synthesis have also described, apparently re-invented in disparate fields, each time taking different computational approaches. The potential value Bayesian estimation a joint posterior parameter distribution and simultaneously sampling from it decision analysis appreciated. However, applications relatively few number, sometimes stylized, presented mainly...
Osteopontin (OPN) and thrombospondin-1 (TSP-1) are extracellular matrix proteins secreted by stromal tumor cells. These appear to have a key role in the microenvironment for cancer development metastasis. There is little information regarding prognostic value of combination these two human cancers. Our aim was clarify clinical significance each circulating protein their primary resected non-small cell lung (NSCLC) patients. We retrospectively reviewed 171 patients with NSCLC following...
Frailty is a challenging issue in China, however the prevalence of frailty across different population groups and whether this changing over time remain unclear. Unstandardized age-and sex-standardized (95 % confidence interval CI)) (Frailty Index) overall sample for subgroups defined by equity factors (PROGRESS-Plus framework) from 2011 to 2020 were estimated using analyses cross-sectional surveys adults aged 45 older participating 5 waves (N = 16,784 18,904 waves) China Health Retirement...