A5011224876- Ruminant Nutrition and Digestive Physiology
- Inflammatory Bowel Disease
- Microscopic Colitis
- Genetic and phenotypic traits in livestock
- Eosinophilic Esophagitis
- Diverticular Disease and Complications
- Gut microbiota and health
- Meat and Animal Product Quality
- Agricultural and Food Production Studies
- Agriculture Sustainability and Environmental Impact
- Agriculture and Rural Development Research
- Autoimmune and Inflammatory Disorders
- Animal Nutrition and Health
- Animal Nutrition and Physiology
- Liver Diseases and Immunity
- Diagnosis and treatment of tuberculosis
- Plant and fungal interactions
- Rabbits: Nutrition, Reproduction, Health
- Tuberculosis Research and Epidemiology
- Reproductive Physiology in Livestock
- Hepatitis B Virus Studies
- Reproductive System and Pregnancy
- Probiotics and Fermented Foods
- Milk Quality and Mastitis in Dairy Cows
- Pregnancy and Medication Impact
Instituto de Ganadería de Montaña
2010-2024
Universidad de León
2015-2024
Unité Mixte de Recherche sur les Herbivores
2021
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021
Hospital Universitario De Cabueñes
2011-2021
Université Clermont Auvergne
2018
VetAgro Sup
2018
University of Campania "Luigi Vanvitelli"
2014
Takeda (United States)
2014
University of Liverpool
2013
To evaluate the safety of thiopurines in patients with inflammatory bowel disease. identify predictive factors associated development thiopurine-induced adverse events.Long-term incidence events was estimated from a prospectively maintained Spanish nationwide database using Kaplan-Meier analysis. Cox regression analysis performed to potential events.Three thousand nine hundred and thirty-one were included. Ninety-five percent on azathioprine. The median follow-up 44 months (range, 0-420)....
The safety of thiopurines and anti-tumor necrosis factor-α (TNF-α) drugs during pregnancy remains controversial, as the experience with these in this situation is limited. Our aim to assess anti-TNF-α for treatment inflammatory bowel disease (IBD) pregnancy.Retrospective, multicenter study IBD patients. Pregnancies were classified according therapeutic regimens or 3 months before conception: non-exposed group, pregnancies exposed alone (group A), B). An unfavorable Global Pregnancy Outcome...
Abstract Recent evidence suggests that changes in microbial colonization of the rumen prior to weaning may imprint microbiome and impact phenotypes later life. We investigated how dietary manipulation from birth influences growth, methane production, gastrointestinal ecology. At birth, 18 female Holstein Montbéliarde calves were randomly assigned either treatment or control (CONT). Treatment was 3-nitrooxypropanol (3-NOP), an investigational anti-methanogenic compound administered daily...
Tumor necrosis factor-alpha (TNF-alpha) plays a key role in the inflammatory response and pathogenesis of Crohn's disease (CD). TNF-alpha -308A polymorphism within gene promoter has been associated with enhanced production vitro. The aim this study was to investigate effect at -308 on susceptibility phenotypic expression fistulizing CD.The distribution genotypes analyzed 50 patients CD 100 healthy matched controls. TNF-alpha, interleukin-1beta, interleukin-6 serum levels were measured by...
Data regarding the effectiveness of adalimumab (ADA) in treatment perianal fistula patients with Crohn's disease (CD) naive to antitumor necrosis factor (TNF) therapy are scarce.: To assess ADA fistulas CD anti-TNF therapy.A retrospective multicenter study was designed. The Fistula Drainage Assessment Index used clinical response, and Van Assche Ng indexes classify radiologic response (magnetic resonance imaging).A total 46 (83% women, 83% complex fistula) were included. At 6 months, 72%...
Modulating the assembly of ruminal microbiota might have practical implications in production. We tested how an early-life dietary intervention lambs influences diversity and function during after intervention. Microbiota resilience a repeated was also tested. The treatment, aiming to mitigate enteric methane emissions, combined garlic essential oil linseed oil. Fifty-six their dams were allocated two groups treatment (T1) or placebo (C1) drenched from birth until 10 weeks life. Lambs weaned...
Abstract An in vitro trial was carried out to investigate the effects of natural Thymbra capitata essential oil (NEO) and its main compounds [including carvacrol, p -cymene, γ -terpinene given alone or a synthetic combination (SEO)] on ruminal fermentation bacterial community using batch cultures inoculated with digesta incubating two different basal diets [high-forage (F) high-concentrate (C) diet]. After 24 h incubation, primary end-products [gas, methane, volatile fatty acids (VFAs)...
<h3>Objective</h3> Genome-wide association studies (GWAS) have identified multiple risk loci for Crohn9s disease (CD). However, the cumulative exerted by these is low, and likelihood that additional, as-yet undiscovered contribute to of CD very high. We performed a GWAS on southern European population identify new loci. <h3>Design</h3> genotyped 620 901 genome markers 1341 patients 1518 controls from Spain. The top signals representing candidate were subsequently analysed in an independent...
The objective of this study was to evaluate the effects increasing doses [0 (control: CON), 20, 60, 180 and 540 mg/L incubation medium] garlic oil (GO) cinnamaldehyde (CIN) on in vitro ruminal fermentation two diets. Batch cultures mixed microorganisms were inoculated with fluid from four sheep fed a medium-concentrate diet (MC; 50 : alfalfa hay concentrate) or high-concentrate (HC; 15 85 barley straw concentrate). Diets MC HC representative those dairy fattening ruminants, respectively....
Dietary supplementation with linseed, saponins, and nitrate is a promising methane mitigation strategy in ruminant production. Here, we aimed to assess the effects of these additives on rumen microbiota order understand underlying microbial mechanisms abatement. Two 2-by-2 factorial design studies were conducted simultaneously, which also allowed us make broad-based assessment responses. Eight nonlactating cows fed diets supplemented linseed or saponin decrease hydrogen production affect...
The aims of this study were to evaluate the frequency entero-urinary fistulas in a cohort Crohn's disease (CD) patients and analyse outcomes medical surgical therapy. This multicentre retrospective included all CD with diagnosed by presence clinical symptoms confirmed at surgery or radiological endoscopic techniques. We evaluated defined remission as absence confirmation fistula closure. Cox regression analysis was performed factors predictive achieving without need for surgery. Of 6081...
To estimate the impact of infliximab (IFX) on hospital resources for patients with Crohn's disease.Resource use data at least 1 year before (B-IFX) and after (A-IFX) administration were retrospectively collected all treated IFX Hospital Cabueñes (Spain). Direct costs calculated were: hospital-stays, surgeries, out-patient visits, diagnostic laboratory tests, pharmacological treatments, day-care hospitalization administration.Patients (n = 34; mean age treatment: 43.6 years) 9.8 4.3 years...
Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), are expressed in the gastrointestinal tract by different cellular types. Nevertheless, imbalance between MMPs TIMPs plays an important role physiopathology of diverse intestinal inflammatory processes.An immunohistochemical study was performed using tissue arrays specific antibodies against -1, -2, -7, -9, -11, -13, -14, -2 -3. Immunohistochemical staining samples from surgical interventions 30 patients with complicated Crohn's...
Four ruminally cannulated sheep were used in a crossover design to assess the postprandial changes of fiber-degrading microbes solid phase rumen fed 2 high-forage diets. The diets had forage:concentrate ratio 70:30 (DM basis) and either alfalfa (Medicago sativa) hay (AL) or grass (GR) as forage (FOR). Sheep twice daily, samples from digesta taken at 0, 4, 8 h after morning feeding. Postprandial DNA concentrations all determined microbial populations similar for Samples 4 feeding lesser (P <...
Thirty Assaf male lambs (30 ± 1.9 kg of body weight) were allocated to three groups fed diets differing in their crude protein (CP) contents (low (LP), 134 g CP/kg dry matter (DM); medium (MP), 157 DM; and high (HP), 173 DM) test the effect dietary content on animal performance, rumen function, health, carcass meat quality. Feed intake was recorded daily, animals weighed every second week. Lambs blood-sampled determine acid-base status biochemical profile. After 70 days trial, slaughtered,...
To assess the likelihood of detecting latent tuberculosis infection [LTBI] by positive conversion a serial tuberculin skin test [TST] at 1 year in inflammatory bowel disease [IBD] patients with negative baseline two-step TST.In this multicentre prospective cohort study, we evaluated rate and predictors TST TST. We also management who had or year. In all assessed TB cases occurring during follow-up.Of 192 IBD receiving anti-tumour necrosis factor [TNF] 220 controls not anti-TNF, 35 [8.5%, 95%...
SUMMARY The objective of the current study was to assess how closely batch cultures (BC) rumen microorganisms can mimic dietary differences in fermentation characteristics found rumen, and analyse changes bacterial diversity over vitro incubation period. Four ruminally duodenally cannulated sheep were fed four diets having forage : concentrate ratios (FCR) 70 30 or 70, with either alfalfa hay grass as forage. Rumen fluid from each used inoculate BC containing same diet donor sheep, main...