Cristina Verdejo
A5062260567- Inflammatory Bowel Disease
- Microscopic Colitis
- Retinal Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Drug-Induced Ocular Toxicity
- Celiac Disease Research and Management
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Advanced Glycation End Products research
- Diagnosis and treatment of tuberculosis
- Iron Metabolism and Disorders
- Ocular Disorders and Treatments
- Dysphagia Assessment and Management
- Antibiotic Use and Resistance
- Helicobacter pylori-related gastroenterology studies
- Intestinal and Peritoneal Adhesions
- Infectious Diseases and Tuberculosis
- Pancreatic and Hepatic Oncology Research
- Biliary and Gastrointestinal Fistulas
- Vascular Procedures and Complications
- Systemic Lupus Erythematosus Research
- Glaucoma and retinal disorders
Hospital General Universitario de Ciudad Real
2014-2023
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2019
Universitat Ramon Llull
2019
Universidad Autónoma de Madrid
2019
Hospital Clínico San Carlos
2017-2018
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2017-2018
Icahn School of Medicine at Mount Sinai
2015
Hospital Universitario Doctor Peset
1999-2014
Hospital Universitario Virgen del Rocío
2008
Universitat de València
2000
ObjectiveParadoxical growth (PG) and trailing effect (TE) are frequently observed during antifungal susceptibility testing (AFST). These two phenomena interfere with the determination of minimal inhibitory concentration (MIC). The aim this study was to assess clinical impact TE PG.MethodsWe analysed frequency PG 690 Candida isolates collected from a population-based performed in Spain (CANDIPOP) correlated results outcome patients.ResultsAround 70% (484/690) exhibited azoles. tropicalis...
A growing incidence of inflammatory bowel disease (IBD) has been reported recently in southern Europe, with records pediatric cases confirming these tendencies Spain. Data on adult populations, however, have not provided for over 10 years and need to be updated.A multicenter retrospective registry all patients a diagnosis IBD, including both Crohn's (CD) ulcerative colitis (UC), attending five public hospitals covering population 514 368 inhabitants, was assessed.In 2012, the prevalence CD...
Background Fecal calprotectin (FC) is a widely used noninvasive marker of gut inflammation that associated with endoscopic severity in Crohn’s disease (CD). However, FC has been inconsistent predicting postoperative recurrence CD, and its utility the setting remains unclear. Materials methods Blood fecal samples were collected consecutively recruited patients CD who had undergone ileocolonic resection required colonoscopy to assess recurrence, as defined by Rutgeerts score (RS). Results A...
Inflammatory bowel disease (IBD) is characterized by an impaired intestinal barrier function. We aimed to investigate the role of reticulon-4B (RTN-4B/NOGO-B), a structural protein endoplasmic reticulum, in function and IBD. used immunohistochemistry, confocal microscopy, real-time PCR, Western blotting study tissue distribution expression levels RTN-4B/NOGO-B control IBD samples from mouse humans. also targeted using siRNAs cultured human epithelial cell (IECs). Epithelial permeability was...
Sensitivity of tuberculin skin test [TST] during screening for latent tuberculosis infection [LTBI] is affected by steroid and/or immunosuppressant therapy. The aim this study was to compare performance the two-step TST in inflammatory bowel disease patients immediately before anti-tumour necrosis factor [TNF] therapy as part routine LTBI vs control when carried out at an early stage.In multicentre prospective controlled study, we evaluated with 5-mm threshold. Factors associated results...
Inflammatory bowel disease (IBD) is associated with a considerable burden to the patient and society. However, current data on IBD incidence are limited because of paucity nationwide epidemiological studies, heterogeneous designs, low number participating centers sample size. The EpidemIBD study large-scale investigation provide an accurate assessment in Spain, as well treatment patterns outcomes.This multicenter, population-based cohort included patients aged >18 years (Crohn's disease,...
To assess the likelihood of detecting latent tuberculosis infection [LTBI] by positive conversion a serial tuberculin skin test [TST] at 1 year in inflammatory bowel disease [IBD] patients with negative baseline two-step TST.In this multicentre prospective cohort study, we evaluated rate and predictors TST TST. We also management who had or year. In all assessed TB cases occurring during follow-up.Of 192 IBD receiving anti-tumour necrosis factor [TNF] 220 controls not anti-TNF, 35 [8.5%, 95%...
Background: The objective of this study was to analyse the prevalence metabolic bone disease (MBD) in a cohort Southern European patients with inflammatory bowel (IBD) and identify associated risk factors population. Methods: We conducted retrospective, both cross-sectional longitudinal MBD, assessed by dual energy X-ray absorptiometry (DXA), among diagnosed IBD previously recognized for complication from two referral Spanish institutions. Results: A total 612 (58.6% Crohn’s disease) were...
Epidemiological and experimental studies suggest the involvement of lipid peroxidation (LPO) in retinal diseases. Clinicians usually prescribe antioxidants to help treatment proliferative diabetic vitreoretinopathy age-related macular degeneration. In spite this, these processes inexorably induce visual impairment may progress towards blindness. addition other pathogenic mechanisms not fully understood, it be that peroxidic aldehydes from LPO occurring eyes, acting as cytotoxic chemicals,...
Thiopurines are the most widely used immunosuppressants in inflammatory bowel disease (IBD). However, patients using these drugs present drug-related adverse effects (AE) 20–30% of cases. In a previous study, we observed different profile thiopurine-related AE elderly-onset IBD. On other hand, use biological agents elderly could be associated with an increased risk infections, so they not clear alternative. Our aim was to evaluate safety thiopurines IBD according age initiation treatment....
Screening for latent tuberculosis infection (LTBI) before starting therapy with anti tumor necrosis factor (anti-TNF) antibodies has decreased the risk of active tuberculosis. Corticosteroids (CS) or immunosuppressive (IS) negatively affected performance Tuberculin skin test (TST). The aim this study was to determine impact CS and IM on likelihood detecting LTBI using a 2-step TST. We also attempted evaluate whether testing at an early stage increases sensitivity This prospective multicenter...