A5076400447- Inflammatory Bowel Disease
- Microscopic Colitis
- Systemic Lupus Erythematosus Research
- Biosimilars and Bioanalytical Methods
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hepatitis C virus research
- Gastrointestinal disorders and treatments
- Celiac Disease Research and Management
- Colorectal Cancer Screening and Detection
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- Diagnosis and treatment of tuberculosis
- Gastric Cancer Management and Outcomes
- Psoriasis: Treatment and Pathogenesis
- Pharmaceutical studies and practices
- COVID-19 and healthcare impacts
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Grief, Bereavement, and Mental Health
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Religion, Spirituality, and Psychology
- Mycobacterium research and diagnosis
- Lipid metabolism and disorders
Hospital Universitario Nuestra Señora de Candelaria
2007-2025
Hospital General Universitario Morales Meseguer
2019
Centro de Ciencias Humanas y Sociales
2012
Abstract Background Factors influencing the exposure to targeted therapies (biologics/JAKi), intestinal resections and hospitalisations in newly diagnosed IBD patients have been scarcely studied. Aim: To identify predictive factors of biologics/JAKi, surgeries, within first five years patients. Methods Prospective, population-based nationwide registry. Adult with [Crohn’s disease (CD), ulcerative colitis (UC) or unclassified (IBD-U)] during 2017 17 Spanish regions were included. Patients who...
Patients with colonic inflammatory bowel disease (IBD) have a high risk of colorectal cancer (CRC). Current guidelines recommend endoscopic surveillance, yet epidemiological studies show poor compliance. The aims our study were to analyse adherence its impact on advanced lesions, and factors non-adherence.A retrospective multicentre IBD patients criteria for CRC diagnosed between 2005 2008 followed up 2020, was performed. Following European guidelines, stratified into groups considered when...
Summary Background Ulcerative proctitis (UP) can have a milder, less aggressive course than left‐sided colitis or extensive colitis. Therefore, immunosuppressants tend to be used in patients with this condition. Evidence, however, is scarce because these are excluded from randomised controlled clinical trials. Our aim was describe the characteristics of refractory UP and their disease‐related complications, identify need for immunosuppressive therapies. Methods We identified prospective...
Inflammatory bowel disease (IBD) is associated with a considerable burden to the patient and society. However, current data on IBD incidence are limited because of paucity nationwide epidemiological studies, heterogeneous designs, low number participating centers sample size. The EpidemIBD study large-scale investigation provide an accurate assessment in Spain, as well treatment patterns outcomes.This multicenter, population-based cohort included patients aged >18 years (Crohn's disease,...
Argon plasma coagulation (APC) is a noncontact technique of electrocoagulation in which energy transmitted via ionized argon gas flow. The tip the catheter should be kept between 1 mm and 3 away from mucosa. APC has become increasingly popular for treating gastric antral vascular ectasia (GAVE). Its main advantage that more superficial, thus reducing risk complications [1].
Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical phenotypic differences. To date, no study has focused on the population in Spain.Prospective, observational, multicenter cohorts of from ENEIDA-registry who were born outside Spain a cohort patients.We included 13,524 (1,864 11,660 native). The immigrants younger (45 ± 12 vs. 54 16 years, p < 0.001), had been diagnosed (31 36 15 shorter disease duration (14 7 18 8 0.001) than patients....
Abstract Background The prevalence of hepatitis C virus infection (HCV) in patients with inflammatory bowel disease (IBD) ranges from 1–6%. Direct-acting antivirals (DAAs), cure rates &gt;90%, represent a radical change interferon-based therapies. ECCO guidelines (Kucharzik JCC 2021) warns about the risk IBD reactivation due to effect DAAs, but HCV management this situation is uncertain given lack evidence. AIMS: To evaluate: 1) Effectiveness and safety DAAs IBD; 2) Interaction drugs,...
Background: Infliximab seems to be the most efficacious of three available anti-TNF agents for ulcerative colitis (UC) but little is known when it used as second anti-TNF. Objectives: To compare clinical and treatment outcomes a subcutaneous or intravenous in UC patients. Design: Retrospective observational study. Methods: Patients from ENEIDA registry treated consecutively with infliximab (or vice versa), naïve other biological agents, were identified grouped according administration route...
Abstract Background Aims: 1) To describe the main epidemiological and clinical characteristics of patients at IBD diagnosis long-term outcomes; 2) to analyse use drugs for IBD, need hospitalisations surgeries; 3) compare management based on type disease resources hospitals. Methods Prospective, population-based nationwide registry. Adult diagnosed with Crohn’s Disease (CD), Ulcerative Colitis (UC) or unclassified, during 2017 in 17 Spanish regions were included. Patients who consented...
Abstract Background Anti-TNF drugs have proven effective in managing Inflammatory Bowel Disease (IBD), but a significant percentage of patients exhibit primary or secondary non-response. Therapeutic drug monitoring (TDM) is valuable tool for optimizing patient management. HLA-DQA1*05 gene has been investigated as potential marker immunogenicity and loss response to anti-TNF therapy.This prospective, multicentric study aimed assess the clinical impact determining Adalimumab (ADA) levels...
Randomised clinical trials have confirmed that biological therapy with anti-tumour necrosis factor (anti-TNF) agents is an effective treatment to induce remission as well avoid hospitalisation and colectomy in ulcerative colitis (UC). Infliximab (IFX) Adalimumab (ADA) are available for UC, Spain, since 2009 2012, respectively. Aim: assess the long-term effectiveness of anti-TNF UC a real-world setting. A retrospective multicentre cohort study was performed on patients receiving between 2015,...
inhibitors of tumor necrosis factor alpha (anti-TNFs) are effective drugs for the treatment moderate-to-severe ulcerative colitis (UC). However, many patients do not respond or lose therapeutic response during follow-up.to analyze determining factors clinical to anti-TNFs in UC.a multicenter retrospective study was performed 79 with UC who started between 2009 and 2015. The primary endpoint remission (pMayo index ≤ 1) at 12 months. Furthermore, (final pMayo score 3) corticoids...
Abstract Background Some patients with Inflammatory Bowel Disease (IBD) who are treated anti-TNFα therapy develop a drug-induced psoriasis (IP) as an adverse event. There some therapeutic approaches, being more frequent to change the biologic ustekinumab, effective and approved for treatment of both entities. This could be best option, but available data lacking it increase risk IBD relapse. Our aim is assess management anti-TNF IP in IBD, subsequent evolution diseases large nationwide...
Abstract Background Ulcerative proctitis may have a mild and less aggressive course, although evidence is scarce because these patients are excluded from participation in randomized controlled clinical trials. The aim to identify characteristics complications associated with ulcerative refractory conventional therapy. Methods Patients included the prospectively maintained ENEIDA registry GETECCU were included. Socio-demographic data evaluated. We defined based on ECCO guidelines...
Abstract Background Inflammatory bowel disease (IBD) has been associated with an abnormal lipid profile. Apolipoprotein C3 (ApoC3) is a key molecule of triglycerides metabolism that known to be related inflammation and cardiovascular (CV) disease. In the present study, we aim study if ApoC3 serum levels differ between patients IBD controls, hypothetical disturbance can explained by characteristics. Methods Cross-sectional included 405 individuals, 197 208 age- sex-matched controls. standard...
Abstract Background During the COVID-19 pandemic, outpatient activity and performance of complementary tests have been limited in order to optimize health care resources patients with SARS-CoV2 infection according incidence cases each time period. The aim this study was determine impact measures implemented by pandemic on diagnosis, initiation treatment, follow-up referred for suspected inflammatory bowel disease (IBD) at different times during pandemic. Methods Retrospective multicenter...
Abstract Background Patients with colon Inflammatory Bowel Disease (IBD) have a higher risk of colorectal cancer (CRC) than general population. Current guidelines establish endoscopic surveillance recommendations; however, epidemiological studies show poor compliance. The main aim our study was to analyse adherence guidelines. Secondary evaluate the prevalence and time-to advanced lesions or CRC. Methods Retrospective multicentre patients IBD followed-up in participating centres between 2005...
Abstract Background Inflammatory bowel disease (IBD) is considered a chronic inflammatory state that has been associated with nonalcoholic fatty liver (NAFLD). Insulin resistance (IR) linked to NAFLD and inflammation. Whether if IR prevalent in IBD increases the risk of these patients unknown. We aimed study cohort factors. Methods This multicentric cross-sectional compared 151 174 age matched non-diabetic controls. C-peptide serum levels beta cell function (%B) indices by homoeostatic model...
Abstract Background Crohn’s disease (CD) can develop fistulizing complications at any time during the course. Enterocutaneous fistulas (ECF) are disabling lesions with a significant impact on quality of life. The aim this study was to describe characteristics and natural history ECF complicating CD, analyze its medical and/or surgical management. Methods A retrospective analysis all adult patients CD least one episode from ENEIDA registry (over 68,000 patients) performed. were defined as...