A5087703458- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Glycosylation and Glycoproteins Research
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Lymphoma Diagnosis and Treatment
- Inflammatory Bowel Disease
- Respiratory viral infections research
- Chronic Lymphocytic Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Autoimmune Bullous Skin Diseases
- HER2/EGFR in Cancer Research
- Organ Donation and Transplantation
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
Hospital Universitario de Canarias
2014-2024
Universidad de La Laguna
2017-2024
Hospital de Especialidades
1998-2006
Lund University
2000-2006
Hospital Universitario Puerta de Hierro Majadahonda
2000-2005
Universidad Autónoma de Madrid
2000-2001
Mexican Social Security Institute
1998
Academia Nacional de Medicina Venezuela
1995
Thirty silent lupus nephritis (SLN) patients were compared to 16 individuals bearing overt (OLN). Results included: years of systemic erythematosus (SLE) diagnosis significantly earlier (4.6 ± 2.8 years) in SLN than OLN (7.18 3.61) ( P < 0.05). Neurological compromise, hypertension, normocitic anemia and lymphopenia prevalent Beside normal urinary sediment renal function tests, the group showed a moderate increase both activity (AI) chronicity (CI) pathology index when highly increased AI...
Abstract The antigen binding site of an antibody is made up residues residing in six hypervariable loops the heavy and light chains. In most cases several or all these are required for establishment antigen‐binding surface. Five display a limited diversity length sequence while third complementarity determining region (CDR) chain highly different between antibodies not only with respect to but also length. Its extensive key component sites allowing recognition essentially any by humoral...
Vitamin A may have some influence on the immune system, but role in allergy modulation is still unclear.To clarify whether high levels of retinoic acid (RA) affects allergic response vivo, we used a murine experimental model airway disease.Ovalbumin (OVA)-immunization/OVA-challenge (OVA/OVA) and house dust mite (HDM)-immunization/HDM-challenge (HDM/HDM) models disease, using C57Bl.10/Q groups mice (n = 10) treated subcutaneously with different concentrations all-trans RA (0, 50, 500 2,500...
Angiogenesis has a key role in several conditions and is regulated by factors such as the platelet-derived growth factor (PDGF) or vascular endothelial (VEGF). The goal of this study was to investigate possible PDGF VEGF group patients with severe food allergy.We design prospective longitudinal (n = 30) persistent cow's milk proteins (CMP) allergy. After achieving CMP rush desensitization protocol, clinical followup including SPT blood samples determine sIgE, protein levels, PDGF, VEGF-A...
Background: Monitoring cellular immune responses elicited in vaccinated individuals is highly complicated. Methods: 28 participated during the vaccination process with 12 BNT162b2 mRNA (Pfizer) vaccine. Specific anti-RBD IgG using a classic ELISA was performed days 10 and 20 (after one dose of vaccine) on day 35 two vaccine doses) serum samples all participants. In parallel, DTH (delayed-type hypersensitivity) Skin Test S protein before (11/28) after doses (28/28) Results: 6/28 were...
A specific immune response against the individual idiotypic determinants of clonal immunoglobulins can be elicited in patients with B-cell malignancies. We analyze clinical outcome and presence tumor cells blood 8 follicular lymphoma, vaccinated autologous idiotype protein from their lymphoma cells. After a median follow-up 90 months (range: 54 to 128), all patients, except 1, remain complete remission 5 are molecular remission. Our results suggest that vaccination induces long-lasting...
The prevalence of many phenotypes food allergy is increasing. Specific gastrointestinal (GI) phenotype (GI allergy) also increasing but it difficult to know the because entities. A 1 year retrospective study pediatric patients complaining exclusively symptoms after cow's milk consumption and at least one positive specific IgE (sIgE) (CM) proteins (CMP) was done (n = 39). most prevalent symptom abdominal cramps in 35 (90 %), discomfort or distention 30 (75 diarrhea 10 (25 %) constipation 5...
Publicidadinflammation and not from irritation or other causes.There were no symptoms to evoke possible causes of epistaxis, eg, unilateral nasal blockage, facial pain, headaches, swelling/deformity, South-East Asian origin (nasopharyngeal carcinoma), loose teeth, otalgia (according an update on epistaxis [4]).Furthermore, in the present case, olfactory dysfunction may be result upper respiratory inflammation obstruction.There was cranial trauma associated signs.Our findings could support...
The term undifferentiated connective tissue disease (UCTD) is used to describe undiagnosed patients that do not fulfill classification criteria for definite (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis). It important find serological markers as predictors of the evolution or severity these diseases. objective this retrospective study was investigate if there a milder subgroup UCTD with special clinical profile consisting only in presence anti-Ro52...
To study whether renal failure enhances gastric mucosal nitric oxide (NO) formation in the rat, we measured 1) vivo NO concentration and 2) synthase (NOS) activity, content, mRNA expression homogenates of uremic sham-operated anesthetized rats. Gastric release was by an electrochemical technique. NOS content analyzed Western immunoblots, using specific monoclonal antibodies. Constitutive (Ca2+ dependent; cNOS) inducible independent; iNOS) activities were assayed following conversion...
and Longo et al [7
We present a female kidney transplant patient under conventional immunosuppression therapy. Her humoral immunity study (anti-spike-specific antibodies) was negative after the initial regimen and third dose of vaccination against COVID-19. The specific ex vivo cellular immune spike SARS-CoV-2 by interferon gamma release assay (IGRA) also remained at non-response levels different time points despite an optimal non-specific cell response assessment. However, test delayed-type hypersensitivity...