A5004556215- Phagocytosis and Immune Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Immune cells in cancer
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Nitric Oxide and Endothelin Effects
- Liver Diseases and Immunity
- S100 Proteins and Annexins
- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Platelet Disorders and Treatments
- Extracellular vesicles in disease
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Universitätsklinikum Erlangen
2016-2025
Center for Rheumatology
2020-2024
University Hospital of Zurich
2023
Schiller International University
2023
German Climate Computing Centre
2020
Emory University
2017-2019
Universidad de Cantabria
2018
Fraunhofer Institute for Cell Therapy and Immunology
2016
Complejo Hospitalario de Jaén
2016
Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark of systemic lupus erythematosus (SLE). However, the mechanisms involved in breaking immunological tolerance these poorly immunogenic nuclear components are not fully understood. Impaired phagocytosis apoptotic cells with consecutive release antigens may contribute to immune pathogenesis. The architectural chromosomal protein proinflammatory mediator high mobility group box 1 (HMGB1) is tightly attached...
Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger in COVID-19 are incompletely understood.
Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these through deep depletion of B cells is a potential strategy achieving sustained drug-free remission.
<h3>Objectives</h3> Autophagy is a homeostatic process to recycle dispensable and damaged cell organelles. Dysregulation of autophagic pathways has recently been implicated in the pathogenesis various diseases. Here, we investigated role autophagy during joint destruction arthritis. <h3>Methods</h3> osteoclasts was analysed vitro ex vivo by transmission electron microscopy, Western blotting immunohistochemistry for Beclin1 Atg7. Small molecule inhibitors, LysMCre-mediated knockout Atg7...
Crystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals cell death. Here we report that of calcium oxalate, monosodium urate, pyrophosphate dihydrate cystine trigger caspase-independent death five different types, which is blocked by necrostatin-1. RNA interference for receptor-interacting protein kinase 3 (RIPK3) or mixed lineage domain like (MLKL), two core proteins necroptosis pathway, blocks crystal...
Abstract Ductal occlusion has been postulated to precipitate focal pancreatic inflammation, while the nature of primary occluding agents remained elusive. Neutrophils make use histone citrullination by peptidyl arginine deiminase-4 (PADI4) in contact particulate extrude decondensed chromatin as neutrophil extracellular traps (NETs). In high cellular density, NETs form macroscopically visible aggregates. Here we show that such aggregates inside ducts humans and mice thereby driving...
Monomeric serum immunoglobulin A (IgA) can contribute to the development of various autoimmune diseases, but regulation IgA effector functions is not well defined. Here, we show that two subclasses (IgA1 and IgA2) differ in their effect on immune cells due distinct binding signaling properties. Whereas IgA2 acts pro-inflammatory neutrophils macrophages, IgA1 does have pronounced effects. Moreover, different glycosylation profiles, with possessing more sialic acid than IgA2. Removal increases...
The NALP3 inflammasome is activated by low intracellular potassium concentrations [K(+)](i), leading to the secretion of proinflammatory cytokine IL-1β. However, mechanism [K(+)](i) lowering after phagocytosis monosodium urate crystals still elusive. Here, we propose that endosomes containing fuse with acidic lysosomes. pH in phagolysosome causes a massive release sodium and raises osmolarity. This process balanced passive water influx through aquaporins cell swelling. dilutes values below...
Significance The current widespread exposure of humans to natural as well man-made nanomaterials due the deployment nanoparticles (NPs) food additives, vaccine- or drug-delivery vehicles, and in diagnostic procedures encourages evaluation their interaction with innate immune system. Understanding how organisms cope hydrophobic chemically inert particulate matter, which is excluded from metabolic processing, major importance for interpreting responses associated use NPs biosphere. containment...