A5042940572- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Child Therapy and Development
- Psychology of Development and Education
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Digestive system and related health
- Glycosylation and Glycoproteins Research
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Nutrition, Genetics, and Disease
- Sociopolitical Dynamics in Russia
- Education and Professional Development
- Pregnancy and Medication Impact
- Reservoir Engineering and Simulation Methods
- Digital Storytelling and Education
- Spatial and Cultural Studies
- Stochastic processes and financial applications
- Chronic Lymphocytic Leukemia Research
- Vasculitis and related conditions
- Risk and Portfolio Optimization
- Educational Methods and Teacher Development
Universitätsklinikum Erlangen
2019-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020-2025
Koltzov Institute of Developmental Biology
2024
Lomonosov Moscow State University
2004-2024
Bulgarian Academy of Sciences
2022
Institute of Science and Technology Austria
2020
Moscow State University of Psychology & Education
2015-2019
Moscow Region State University
2019
Royal Bank of Scotland (United Kingdom)
2017
Imperial College London
2017
Monomeric serum immunoglobulin A (IgA) can contribute to the development of various autoimmune diseases, but regulation IgA effector functions is not well defined. Here, we show that two subclasses (IgA1 and IgA2) differ in their effect on immune cells due distinct binding signaling properties. Whereas IgA2 acts pro-inflammatory neutrophils macrophages, IgA1 does have pronounced effects. Moreover, different glycosylation profiles, with possessing more sialic acid than IgA2. Removal increases...
Abstract Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism this tolerance-inducing effect alcohol, however, unknown. Here we show that alcohol and its metabolite acetate alter functional state T follicular helper (T FH ) cells in vitro vivo, thereby exerting immune regulatory properties. Alcohol-exposed mice have reduced Bcl6 PD-1 expression well IL-21 production by cells, preventing...
Short-chain fatty acids are microbial metabolites that have been shown to be key regulators of the gut-joint axis in animal models. In humans, dysbiosis was observed rheumatoid arthritis (RA) patients as well those at-risk develop RA, and is thought an environmental trigger for development clinical disease. At same time, diet has a proven impact on maintaining intestinal homeostasis. Given this association, we performed feasibility study RA using high-fiber dietary supplementation with...
Objective B cell depletion is an established therapeutic principle in a wide range of autoimmune diseases. However, cells are also critical for inducing protective immunity after infection and vaccination. We undertook this study to assess humoral cellular immune responses with or vaccination against SARS–CoV‐2 patients controls who cell–competent. Methods Antibody (tested using enzyme‐linked immunosorbent assay) T interferon‐γ immunospot the spike S1 nucleocapsid proteins were assessed...
Abstract Background C-reactive protein (CRP) is often normal in patients with psoriatic disease. Herein, we aimed to define markers of systemic inflammation monomorphic and polymorphic skin, entheseal, joint Methods Three-step approach: (i) selection serum elevated arthritis compared healthy controls from a panel 10 different reflecting the pathophysiology disease; (ii) testing these selected as well larger cohort 210 individuals- 105 disease either skin (S), entheseal (E) or (A) involvement...
To test whether the presence of structural entheseal lesions in psoriasis patients influences risk progression to psoriatic arthritis (PsA).We conducted a prospective cohort study without clinical evidence musculoskeletal involvement who underwent baseline assessment and volumetric bone mineral density (vBMD) at intraarticular sites by high-resolution peripheral quantitative computed tomography. Adjusted relative risks developing PsA associated with vBMD were calculated using multivariable...
Neutrophil extracellular trap (NET) formation is a powerful instrument to fight pathogens, but may induce collateral damage in the affected tissues. Besides pathogen-derived factors, immune complexes are potent inducers of NET formation. Neutrophils express IgA and IgG specific Fc receptors (FcRs) therefore respond complexed IgG. Especially context autoimmune diseases, have been shown trigger formation, process that putatively contributes disease severity. However, it question if both...
Abstract Background Glycosylation is an important posttranslational modification of proteins and in most cases indispensable for proper protein function. Like soluble proteins, IgA, the second prevalent antibody human serum, contains several N- O-glycosylation sites. While IgG impact Fc glycosylation on effector functions inflammatory potential has been studied intensively, only little known IgA. In addition, glimpses exist regarding regulation IgA glycosylation. We have previously shown...
Certolizumab pegol (CZP) is a PEGylated antigen-binding fragment-fragment of humanized mAb neutralizing TNF. It lacks Fc-fragment and has very low potential to cross the placenta. We aimed report efficacy safety CZP in case series patients with refractory Takayasu arteritis (TA). Ten females reproductive age (18–35 years) TA were treated (at dose 400 mg at weeks 0, 2 4 200 every thereafter) for median 10 months (range 3–28). Prior administration all received glucocorticoids ± MTX, CYC, AZA,...
Cellular lipid uptake (through endocytosis) is a basic physiological process. Dysregulation of this process underlies the pathogenesis diseases such as atherosclerosis, obesity, diabetes, and cancer. However, to date, only some mechanisms endocytosis have been discovered. Here, we show previously unknown mechanism cargo into cells mediated by receptor Mincle. We found that Mincle, shown be pattern recognition innate immune system, tightly binds range self-lipids. Moreover, revealed minimal...
Abstract Objectives A substantial proportion of RA patients flare upon withdrawal DMARDs, and thus the definition prognostic markers is crucial. ACPA positivity has been identified as a risk factor for flare. However, only role IgG established in this context, while IgA poorly defined. We aimed to investigate flaring RA. Methods Serum levels IgA1 IgA2 at baseline after 12 months were measured 108 from randomized controlled RETRO study. stable remission least 6 study recruitment assigned...
Here, for the first time, structure of genes involved in sex determination mammals (full
The tendency to auto-aggressive, including suicidal, behavior in adolescents is a variant of deviant tendencies, which are formed under the influence different factors. consummation destructive information on Internet has been considered lately as one such goal this study was finding correlation between auto-aggressive character and frequency Internet. Content-analysis semantic analysis verbal visual content range groups allowed distinguishing with specially developed inventory — out...
Objective Events triggering disease outbreak in individuals at-risk for rheumatoid arthritis (RA at-risk) remain unclear, and the role of various anticitrullinated protein antibody (ACPA) isotypes this process is still to be established. We aimed investigate prevalence IgA ACPA RA individuals, their transition from status dynamics during transition. Methods Cross-sectional measurement serum IgA1 IgA2 levels was conducted healthy controls, patients with compared frequency development at risk...
OBJECTIVES: The environmental and life-style conditions of the Kola Sami could have influenced population-specific frequencies AGXTProIILeu allele, certain alleles APOE LCT genes, involved respectively, in metabolism animal proteins, lipids milk sugar. Study Design. DNA samples were collected from population Lovozero settlement (Murmansk Region) 2005.METHODS: analysis traditional diet was made using data ethnographic studies conducted nineteenth beginning twentieth centuries. Frequencies...
Disorders of dietary sugar assimilation occur more often among native people the Arctic then in temperate climate inhabitants.It is hypothesized that limited variety natural exogenous sugars Arctic, and their low content traditional diets northerners accordance with a “protein-lipid” type metabolism weakened selection, favoring diversity disaccharidase enzymes.
The article describes the possible application of principles cultural-historical approach and activity theory to inspection toys play environments. A children’s playground is treated as cultural means or artifact created by adults for starting a child’s activity. In terms historical psychology, psycho-pedagogical analysis based on identification value level compliance with objectives peculiar age. Analysis design are understanding single space, where each element has potential any...
Genetically determined deficiency of the lactase enzyme in adults (primary hypolactasia) is a recessive trait. As shown earlier, some European populations primary hypolactasia by carrying CC genotype at single-nucleotide polymorphism (SNP) LCT*С/T-13910. In this work allele and frequencies were estimated for LCT*C/ T-13910 7 samples (346 individuals total), representing Eurasian (Saami, Mari, Russians from Volga-Ural Area, Kazakhs, Uyghurs, Buriats, Arabs). For part these groups earlier...
The paper reviews the specifics of modern toys basing on analysis items presented at annual Nuremberg International Toy Fair. We share our impressions Fair and make an attempt to identify main developmental trends toy market. outline structure that represents typology play materials provide a description character toys, made wood other natural materials. In special focus are winners awards (10 most interesting out 75,000). All in all, there two development toys: first one is related...
Abstract Objectives Psoriatic arthritis (PsA) is associated with bone erosion and inflammation-induced loss, which are mediated by osteoclasts (OC) modulated inflammatory cytokines. Apremilast (APR) (a selective phosphodiesterase 4 inhibitor) efficacious in PsA acts inhibiting cytokine production. However, there no direct data informing whether how APR affects osteoclast formation humans. Methods Osteoclastogenic production activated human peripheral blood mononuclear cells (PBMCs) was...
Limited information exists about the very early forms of psoriatic arthritis. In particular, differences and responsiveness patient-reported outcomes (PROs) in as compared to established PsA have not been investigated date.Cross-sectional prospective longitudinal evaluation PROs related pain (VAS), physical function (HAQ-DI, SF-36 physical), mental (SF-36 mental), impact skin (DLQI), joint (PsAID), global disease (VAS) two small observational studies on secukinumab 300 mg over 6 months...
This paper presents a new approach to investigation of playgrounds’ safety, which has recently become matter special debates in modern foreign psychology and pedagogy. Under this approach, reasonable risk is seen as necessary condition mental development subject psycho-pedagogical analysis. The article discusses some the most topical issues related safety game environment. It shows difference concepts danger. Specificity risky draws attention scholars. provides research evidence, concerning...