A5104146136- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Liver Disease and Transplantation
- Genetics, Aging, and Longevity in Model Organisms
- Hepatitis C virus research
- Tryptophan and brain disorders
- Gut microbiota and health
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Alcohol Consumption and Health Effects
- Telomeres, Telomerase, and Senescence
- Mitochondrial Function and Pathology
- Biosimilars and Bioanalytical Methods
- Herpesvirus Infections and Treatments
Universitätsklinikum Erlangen
2021-2025
Italian Association for Cancer Research
2025
University of Bologna
2012-2024
Azienda USL di Bologna
2022-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2023-2024
Collaborative Group (United States)
2024
Center for Rheumatology
2024
University of Campania "Luigi Vanvitelli"
2020-2022
Leipzig University
2022
Imperial College London
2022
Background Age-related physiological changes in the gastrointestinal tract, as well modifications lifestyle, nutritional behaviour, and functionality of host immune system, inevitably affect gut microbiota, resulting a greater susceptibility to infections. Methodology/Principal Findings By using Human Intestinal Tract Chip (HITChip) quantitative PCR 16S rRNA genes Bacteria Archaea, we explored age-related differences microbiota composition among young adults, elderly, centenarians, i.e...
Background: Age-related physiological changes in the gastrointestinal tract, as well modifications lifestyle, nutritional behaviour, and functionality of host immune system, inevitably affect gut microbiota, resulting a greater susceptibility to infections.Methodology/Principal Findings: By using Human Intestinal Tract Chip (HITChip) quantitative PCR 16S rRNA genes Bacteria Archaea, we explored age-related differences microbiota composition among young adults, elderly, centenarians, i.e...
Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these through deep depletion of B cells is a potential strategy achieving sustained drug-free remission.
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes longevity is still missing. Here using combined metabonomics approach compromising holistic (1)H-NMR and targeted MS approaches, we report for first time well characterized human cohort mostly female centenarians, elderly, young individuals. With increasing age, blood serum displayed marked decrease tryptophan concentration, while an...
<h3>Objectives</h3> CD19-targeting chimeric antigen receptor (CAR) T-cell therapy can induce long-term drug-free remission in patients with autoimmune diseases (AIDs). The efficacy of CD19-CAR is presumably based on deep tissue depletion B cells; however, such effect has not been proven humans vivo. <h3>Methods</h3> Sequential ultrasound-guided inguinal lymph node biopsies were performed at baseline and after AIDs. Results compared from rituximab (RTX)-treated AID absence peripheral cells....
Inflamm-aging, that is the age-associated inflammatory status, considered one of most striking consequences immunosenescence, as it believed to be linked majority diseases sharing an basis. Nevertheless, evidence emerging inflamm-aging at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major display markers inflammation. In this paper we proposed a reappraisal concept inflamm-aging, suggesting its pathological effects can total amount...
Abstract A progressive, systemic, and low-grade proinflammatory status is one of the major characteristics immunosenescence. Emerging data suggest a possible contribution CMV, known to chronically infect large proportion humans, lifelong from newborns centenarians. To test this hypothesis, we evaluated functional T cell responses two CMV immunogenic proteins, pp65 IE-1, in 65 infected subjects aged 25–100 years. PBMC were stimulated with mixtures peptides spanning entire sequence both Ag...
Aging | doi:10.18632/aging.100630. Ivan Montoliu, Max Scherer, Fiona Beguelin, Laeticia DaSilva, Daniela Mari, Stefano Salvioli, François-Pierre J. Martin, Miriam Capri, Laura Bucci, Rita Ostan, Paolo Garagnani, Monti, Elena Biagi, Patrizia Brigidi, Martin Kussmann, Serge Rezzi, Claudio Franceschi, Sebastiano Collino
The Barcelona Clinic Liver Cancer (BCLC) advanced stage (BCLC C) of hepatocellular carcinoma (HCC) includes a heterogeneous population, where sorafenib alone is the recommended treatment. In this study, our aim was to assess treatment and overall survival (OS) BCLC C patients subclassified according clinical features (performance status [PS], macrovascular invasion [MVI], extrahepatic spread [EHS] or MVI + EHS) determining their allocation stage. From Italian database, we analyzed 835...
Objective B cell depletion is an established therapeutic principle in a wide range of autoimmune diseases. However, cells are also critical for inducing protective immunity after infection and vaccination. We undertook this study to assess humoral cellular immune responses with or vaccination against SARS–CoV‐2 patients controls who cell–competent. Methods Antibody (tested using enzyme‐linked immunosorbent assay) T interferon‐γ immunospot the spike S1 nucleocapsid proteins were assessed...
CD19-targeting chimeric antigen receptor (CAR) T-cell therapy has advanced treatment strategies for severe autoimmune diseases such as systemic lupus erythematosus (SLE), sclerosis, and idiopathic inflammatory myopathy. Data regarding side-effects are mostly generated from patients with malignancies, but little is known about disease-specific adverse events. This study aimed to describe events that occur CAR therapy. In this observational study, of any age disease receiving in two centres...
Human aging is characterized by expanded and altered adaptive immune responses to human CMV (HCMV). It unclear whether this expansion has its origins in age-related homeostatic disturbances or viral reactivation, anti-CMV surveillance may still be effective, what are the consequences of response for health longevity. We conducted an observational cross-sectional study groups HCMV-seropositive subjects aged >or=65 y variable status compare intensity Ab against HCMV with those EBV CD4(+)...
Aging | doi:10.18632/aging.100484. Giovanni Vitale, Michael P Brugts, Giulia Ogliari, Davide Castaldi, Letizia M. Fatti, Aimee J. Varewijck, Steven W. Lamberts, Daniela Monti, Laura Bucci, Elisa Cevenini, Francesco Cavagnini, Claudio Franceschi, Leo J Hofland, Mari, Joseph A.M.J.L. Janssen
Inflamm-aging, that is the age-associated inflammatory status, considered one of most striking consequences immunosenescence, as it believed to be linked majority diseases sharing an basis. Nevertheless, evidence emerging inflamm-aging at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major display markers inflammation. In this paper we proposed a reappraisal concept inflamm- aging, suggesting its pathological effects can total amount...
Post-operative delirium (POD) is a common complication in elderly patients undergoing surgery, but the underpinning causes are not clear. We hypothesized that inflammaging, subclinical low and chronic grade inflammation characteristic of old people, can contribute to POD onset. Accordingly, we investigated association pre-operative circulating cytokines (>65 years), admitted for elective emergency surgery.This secondary analysis sub-cohort belonging previous large case-control study, where...
Aging | doi:10.18632/aging.100912. Laura Bucci, Rita Ostan, Elisa Cevenini, Pini, Maria Scurti, Giovanni Vitale, Daniela Mari, Calogero Caruso, Paolo Sansoni, Flaminia Fanelli, Renato Pasquali, Paola Gueresi, Claudio Franceschi, Monti