A5017282401- Gut microbiota and health
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Nutritional Studies and Diet
- Dietary Effects on Health
- Bacteriophages and microbial interactions
- Oral microbiology and periodontitis research
- Neutropenia and Cancer Infections
- Infant Nutrition and Health
- Respiratory viral infections research
- Metabolomics and Mass Spectrometry Studies
- Hematopoietic Stem Cell Transplantation
- Coral and Marine Ecosystems Studies
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Microplastics and Plastic Pollution
- Reproductive tract infections research
- Genomics and Phylogenetic Studies
- Influenza Virus Research Studies
- Microbial Metabolites in Food Biotechnology
- Tryptophan and brain disorders
- Aquaculture Nutrition and Growth
- Ocean Acidification Effects and Responses
University of Bologna
2015-2024
Ecologie Microbienne Lyon
2019-2021
World Water Watch
2011
Wageningen University & Research
2011
Background Age-related physiological changes in the gastrointestinal tract, as well modifications lifestyle, nutritional behaviour, and functionality of host immune system, inevitably affect gut microbiota, resulting a greater susceptibility to infections. Methodology/Principal Findings By using Human Intestinal Tract Chip (HITChip) quantitative PCR 16S rRNA genes Bacteria Archaea, we explored age-related differences microbiota composition among young adults, elderly, centenarians, i.e...
Human gut microbiota directly influences health and provides an extra means of adaptive potential to different lifestyles. To explore variation in understand how these bacteria may have co-evolved with humans, here we investigate the phylogenetic diversity metabolite production from a community human hunter-gatherers, Hadza Tanzania. We show that higher levels microbial richness biodiversity than Italian urban controls. Further comparisons two rural farming African groups illustrate other...
Abstract The gut microbiota is essential for human health and plays an important role in the pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate propionate, are end-products microbial fermentation macronutrients that distribute systemically via blood. aim this study was to investigate transcriptional response immature LPS-matured monocyte-derived DC SCFA. Our data revealed distinct effects exerted by each individual SCFA on gene expression DC,...
Background: Age-related physiological changes in the gastrointestinal tract, as well modifications lifestyle, nutritional behaviour, and functionality of host immune system, inevitably affect gut microbiota, resulting a greater susceptibility to infections.Methodology/Principal Findings: By using Human Intestinal Tract Chip (HITChip) quantitative PCR 16S rRNA genes Bacteria Archaea, we explored age-related differences microbiota composition among young adults, elderly, centenarians, i.e...
Age-related alterations in human gut microbiota composition have been thoroughly described, but a detailed functional description of the intestinal bacterial coding capacity is still missing. In order to elucidate contribution metagenome complex mosaic longevity, we applied shotgun sequencing total fecal DNA selection samples belonging well-characterized ageing cohort. The age-related trajectory microbiome was characterized by loss genes for shortchain fatty acid production and an overall...
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes longevity is still missing. Here using combined metabonomics approach compromising holistic (1)H-NMR and targeted MS approaches, we report for first time well characterized human cohort mostly female centenarians, elderly, young individuals. With increasing age, blood serum displayed marked decrease tryptophan concentration, while an...
The gut microbiota exerts a role in type 2 diabetes (T2D), and deviations from mutualistic ecosystem layout are considered key environmental factor contributing to the disease. Thus, possibility of improving metabolic control T2D by correcting microbiome dysbioses through diet has been evaluated. Here, we explore potential two different energy-restricted dietary approaches - fibre-rich macrobiotic Ma-Pi or recommended Italian professional societies for treatment correct patients. In previous...
Aging is accompanied by physiological changes affecting body composition and functionality, including accumulation of fat mass at the expense muscle mass, with effects upon morbidity quality life. The gut microbiome has recently emerged as a key environmental modifier human health that can modulate healthy aging possibly longevity. However, its associations adiposity in old age are still poorly understood. Here we profiled microbiota well-characterized cohort 201 Italian elderly subjects...
Objective The engagement of the gut microbiota in development symptoms and complications diverticular disease has been frequently hypothesised. Our aim was to explore colonic immunocytes, metabolome patients with a descriptive, cross-sectional, pilot study. Design Following colonoscopy biopsy questionnaire phenotyping, were classified into diverticulosis or symptomatic uncomplicated disease; asymptomatic subjects served as controls. Mucosal region unaffected sites, quantified...
We assessed the subsistence-related variation of human gut microbiome at a fine resolution for two main dimensions variation, age and geography. For this, we investigated fecal metabolome in rural Bassa urbanized individuals from Nigeria, including infants, compared data with worldwide populations practicing varying subsistence. Our highlight specific traits that are progressively lost urbanization, such as dominance pristine fiber degraders low inter-individual variation. Bassa, this last...
The progressive building of the infants' gut microbiota is pivotal for educating their immune system. Human breast milk among first sources microbes assembly infant's microbiota, but research struggles to give a demonstration origin bacteria in milk. Aiming at contributing knowledge on mother's and microbiome, here we characterized oral, ecosystems homogeneous cohort 36 healthy mother-infants pairs, by 16S rRNA next-generation sequencing. A limited number operational taxonomic units (OTUs)...
Aging | doi:10.18632/aging.100630. Ivan Montoliu, Max Scherer, Fiona Beguelin, Laeticia DaSilva, Daniela Mari, Stefano Salvioli, François-Pierre J. Martin, Miriam Capri, Laura Bucci, Rita Ostan, Paolo Garagnani, Monti, Elena Biagi, Patrizia Brigidi, Martin Kussmann, Serge Rezzi, Claudio Franceschi, Sebastiano Collino
Bioinformatics tools available for metagenomic sequencing analysis are principally devoted to the identification of microorganisms populating an ecological niche, but they usually do not consider viruses. Only some software have been designed profile viral sequences, however efficient in characterization viruses context complex communities, like intestinal microbiota, containing bacteria, archeabacteria, eukaryotic and In any case, a comprehensive description host-microbiota interactions can...
The gut microbiome of long-lived people display an increasing abundance subdominant species, as well a rearrangement in health-associated bacteria, but less is known about functions. In order to disentangle the contribution complex trait human longevity, we here describe metagenomic change along with aging subjects up extreme including centenarians (aged 99 104 years) and semisupercentenarians 105 109 years), i.e., demographically very uncommon who reach limit life span. According our...
The intestinal microbial communities and their temporal dynamics are gaining increasing interest due to the significant implications for human health. Recent studies have shown dynamic behavior of gut microbiota in free-living, healthy persons. To date, it is not known whether these applicable during prolonged life sharing a confined controlled environment. MARS500 project, longest ground-based space simulation ever, provided us with unique opportunity trace crew over 520 days isolated...
The recent characterization of the gut microbiome traditional rural and foraging societies allowed us to appreciate essential co-adaptive role in complementing our physiology, opening up significant questions on how microbiota changes that have occurred industrialized urban populations may altered microbiota-host co-metabolic network, contributing growing list Western diseases. Here, we applied a targeted metabolomics approach profile fecal metabolome Hadza Tanzania, one world's few...