A5020760826- Cutaneous lymphoproliferative disorders research
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- Nail Diseases and Treatments
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Toxin Mechanisms and Immunotoxins
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- interferon and immune responses
- Phytochemical compounds biological activities
- Gut microbiota and health
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Telomeres, Telomerase, and Senescence
- IL-33, ST2, and ILC Pathways
- Cancer Research and Treatments
- Escherichia coli research studies
- CNS Lymphoma Diagnosis and Treatment
- Dermatology and Skin Diseases
University of Copenhagen
2014-2023
LEO Foundation
2019-2023
Institute of Molecular Biology
2006
Abstract The gut microbiota is essential for human health and plays an important role in the pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate propionate, are end-products microbial fermentation macronutrients that distribute systemically via blood. aim this study was to investigate transcriptional response immature LPS-matured monocyte-derived DC SCFA. Our data revealed distinct effects exerted by each individual SCFA on gene expression DC,...
The pathogenesis of cutaneous T-cell lymphoma (CTCL) remains elusive. Recent discoveries indicate that the oncogenic microRNA miR-155 is overexpressed in affected skin from CTCL patients. Here, we address what drives expression and investigate its role CTCL. We show malignant T cells constitutively express high levels host gene BIC (B cell integration cluster). Using ChIP-seq, identify as a target transcription factor STAT5, which aberrantly activated induced by IL-2/IL-15 non-malignant...
// Nina A. Sibbesen 1 , Katharina L. Kopp Ivan V. Litvinov 2 Lars Jønson 3 Andreas Willerslev-Olsen Simon Fredholm David Petersen Claudia Nastasi Thorbjørn Krejsgaard Lise M. Lindahl 4 Robert Gniadecki 5 Nigel P. Mongan 6 Denis Sasseville Mariusz Wasik 7 Iversen Charlotte Bonefeld Carsten Geisler Anders Woetmann and Niels Odum Department of Immunology Microbiology, University Copenhagen, Denmark Division Dermatology, McGill Health Centre, Montréal, Quebec, Canada...
Bacterial genotoxins, produced by several Gram-negative bacteria, induce DNA damage in the target cells. While responses induced host cells have been extensively studied vitro, role of these effectors during course infection remains poorly characterized. To address this issue, we assessed effects Salmonella enterica genotoxin, known as typhoid toxin, vivo models murine infection. Immunocompetent mice were infected with isogenic S. enterica, serovar Typhimurium (S. Typhimurium) strains,...
Abstract Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in dermis and epidermis. Skin lesions cause serious symptoms that hamper quality life are entry sites for bacterial infection, major morbidity mortality advanced diseases. The mechanism driving pathological processes compromise skin barrier remains unknown. Here, we report increased transepidermal water loss compromised expression proteins filaggrin...
Staphylococcus aureus is suspected to fuel disease activity in cutaneous T-cell lymphomas. In this study, we investigate the effect of a recombinant, antibacterial protein, endolysin (XZ.700), on S. skin colonization and malignant activation. We show that strongly inhibits proliferation isolated from lymphoma significantly decreases bacterial cell counts dose-dependent manner. Likewise, ex vivo both healthy lesional by profoundly inhibited endolysin. Moreover, patient-derived induction IFNγ...
Abstract Background Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least its initial phases, an anti-tumor response that needs to be circumvented for cancer progress. Micro-RNAs, subclass of regulatory, non-coding RNAs, participate regulation. At the subcellular level micro-RNAs, similar proteins, have been shown traffic between organelles influencing cellular behavior. The differential...
Mycosis fungoides (MF) is the most frequent form of cutaneous T-cell lymphoma. The disease often takes an indolent course, but in approximately one-third patients, progresses to aggressive malignancy with a poor prognosis. At time diagnosis, it impossible predict which patients develop severe and are need treatment. Accordingly, we investigated prognostic potential microRNAs (miRNAs) at diagnosis MF. Using quantitative reverse transcription polymerase chain reaction platform, analyzed miRNA...
// Lise M. Lindahl 1 , Simon Fredholm 2 Claudine Joseph Boye Schnack Nielsen 3 Lars Jønson 4 Andreas Willerslev-Olsen Maria Gluud Edda Blümel David L. Petersen Nina Sibbesen Tengpeng Hu Claudia Nastasi Thorbjørn Krejsgaard Ditte Jæhger Jenny Persson 5 Nigel Mongan 6 Mariusz A. Wasik 7 Ivan V. Litvinov 8 Denis Sasseville 9 Sergei B. Koralov 10 Charlotte Bonefeld Carsten Geisler Anders Woetmann Elisabeth Ralfkiaer 11 Iversen Niels Odum Department of Dermatology, Aarhus...